A coopetition-driven strategy of parallel/perpendicular aromatic stacking enabling metastable supramolecular polymerization.

Metastable supramolecular polymerization under kinetic control has recently been recognized as a closer way to biosystem than thermodynamic process. While impressive works on metastable supramolecular systems have been reported, the library of available non-covalent driving modes is still small and a simple yet versatile solution is highly desirable to design for easily regulating the energy landscapes of metastable aggregation. Herein, we propose a coopetition-driven metastability strategy for parallel/perpendicular aromatic stacking to construct metastable supramolecular polymers derived from a class of simple monomers consisting of lateral indoles and aromatic core.

Memory stem CD8T cells in HIV/Mtb mono- and co-infection: characteristics, implications, and clinical significance.

Human immunodeficiency Virus (HIV) and () co-infection presents a significant public health challenge worldwide. Comprehensive assessment of the immune response in HIV/ co-infection is complex and challenging. CD8T cells play a pivotal role in the adaptive immune response to both HIV and .

Precise Supramolecular Nanoarchitectonics for Simultaneous Enhanced Photoluminescence and Photocatalysis in a Co-Assembly by a Biomimetic Isolation-Conduction Strategy.

Limited by the two mutually exclusive physicochemical processes of separation and recombination of photogenerated carriers, achieving photoluminescence and photocatalysis simultaneously is extremely challenging but essential for ever-growing complex issues and specialized scenarios. Here we proposed a biomimetic isolation-conduction strategy induced by an arene-perfluoroarene (A-P) interaction for enabling photoluminescence and photocatalytic hydrogen evolution reaction (HER) activity in the co-assembly of aromatic monomers and octafluoronapthalene (OFN). Inspired by the isolation-conduction effect of periodic isolation of myelin sheaths on the axons of vertebrate nerve fibers by node of Ranvier, we use OFN as a molecular isolator embedded in the aromatic monomers array to block the singlet-to-triplet pathway, while the enlarged intermolecular dipoles resulting from the A-P interactions facilitate the conduction of photogenerated carriers in the isolated regions.

Intrinsic Multicolor Emissive Aliphatic Linear Polyphosphate Esters From the Charge-Transfer-Induced Enhanced Spatial Electronic Communication.

Unconventional fluorescent polymers are attracting increasing attention because of their excellent biocompatibility and wide applications. However, these polymers typically exhibit weak long-wavelength emission. Herein, three novel aliphatic linear polyphosphate esters are prepared via a one-pot polycondensation reaction.

Study on the Technical Parameters for Estimating HIV-1 Incidence by Using a Recombinant Antigen-based Capture Enzyme Immunoassay - China.

Introduction: A novel recombinant antigen-based capture enzyme immunoassay (RAg-CEIA) was optimized and used to determine technical parameters for estimating human immunodeficiency virus type 1 (HIV-1) incidence in China.

Methods: We employed orthogonal experimental design to optimize RAg-CEIA by adjusting raw material dilution ratios. The assay was used to measure normalized optical density (ODn) values in 171 longitudinal plasma specimens from 51 HIV-1 seroconverting individuals, plotted against estimated days post-seroconversion.

A novel method to enhance the efficiency of aldehyde tanning agents via collagen amination.

The utilization of chromium free tanning agents generates lots of pollutants such as chromium containing wastewater and sludge. Besides, trivalent chromium may be converted into carcinogenic hexavalent chromium under certain conditions, causing permanent harm to the human body. Therefore, the promotion of chromium free tanning technology is extremely significant.

The cGAS-STING pathway in HIV-1 and Mycobacterium tuberculosis coinfection.

Mycobacterium tuberculosis (M. tuberculosis) infection is the most common opportunistic infection in human immunodeficiency virus-1 (HIV-1)-infected individuals, and the mutual reinforcement of these two pathogens may accelerate disease progression and lead to rapid mortality. Therefore, HIV-1/M.

Thiol-containing hyperbranched polysiloxane for scavenging reactive oxygen species.

Unconventional luminescent polymers have attracted considerable attention in the biological field due to their intrinsic fluorescence properties and excellent biocompatibility. However, exploring the luminescent properties of thiol-containing polymers and the mechanism of their scavenging of ROS remains unclear. In this work, we synthesised three kinds of hyperbranched polysiloxanes (HE, HP, and HB) with terminal thiol groups containing different chain lengths by the polycondensation reaction.

Achieving Controllable Thermochromic Fluorescence via Synergistic Intramolecular Charge Transfer and Molecular Packing.

Thermochromic fluorescent materials (TFMs) have attracted significant attention due to their unique fluorescent colorimetric response to temperature. However, existing TFMs still suffer from weak stimulus responsiveness, broad temperature response ranges, uncontrollable emission color changes, and low quantum yields. In this study, we address these issues by designing and synthesizing three diketone-boron complexes with distinct emission wavelengths (NWPU-(2-4)).

Meta-analysis of the effects of bundle interventions on ICU-acquired weakness intervention.

Background: Intensive care unit acquired weakness (ICU-AW) is a secondary neuromuscular complication in critically ill patients, characterized by profound weakness in all four limbs. Studies have shown that bundles of care are nursing strategies that combine a series of evidence-based interventions, which collectively optimize patients' clinical outcomes compared to individual interventions.

Objective: This study aims to conduct a meta-analysis of the effects of bundle interventions on ICU-AW deeply exploring the characteristics of bundle interventions, patient outcomes related to ICU-AW, and primarily investigating the effects of bundle interventions on ICU-AW.

Recent Advances of Organic-Inorganic Hybrid Fluorescent Hyperbranched Polymer: Synthesis, Performance Regulation Strategies and Applications.

The organic-inorganic hybrid fluorescent hyperbranched polymer, including hyperbranched polysiloxane and hyperbranched polyborate, have attracted much attention due to their excellent optical properties and wide range of applications. Hyperbranched polysiloxane and polyborates, prepared by introducing Si or B elements into organic polymer chains at the molecular level through rational molecular design and novel synthesis methods, exhibit outstanding photophysical properties as an indispensable branch of organic-inorganic hybrid fluorescent materials. Herein, this review highlights the recent research progress on hyperbranched polysiloxanes and hyperbranched polyborates, including strategies for regulating their emission wavelengths, quantum yields, and fluorescence lifetimes, potential emission mechanisms, and various applications.

Cardiovascular comorbidities among patients with psoriasis: a national register-based study in China.

This study aims to illustrate epidemiology of comorbid CVD in the real-world clinical setting of patients with psoriasis in China. We used data of adult patients with psoriasis who were registered in the register of China National Clinical Center for Skin and Immune Diseases between August 2020 and September 2021. Psoriasis was clinically diagnosed following the national guidelines.

Si, B-containing dynamic covalent bonds enable excellent flame retardancy and reduced fire hazards for cyanate ester resin.

Cyanate ester (CE) resins are distinguished by excellent dielectric properties in electronic packaging materials but face significant fire risks, with existing strategies often compromising their processability or original properties. Herein, we propose an innovative strategy involving the exchange of dynamic covalent bonds under heat stimuli aimed at forming a continuous and compact char layer to enhance the fire safety of CE resin. Using a straightforward one-pot method, dynamic Si-O and B-O bonds were integrated into a novel hyperbranched polymer (HPSiB), ensuring good compatibility with CE resin while lowering its peak curing temperature by 185 °C for facile processability.

Aliphatic hyperbranched polyphosphate: a novel multicolor RTP material with AIE character.

Long-lived photoluminescent probes are emerging as significant luminogens for biological imaging. However, currently, most long-lived luminescent materials contain expensive rare elements or cytotoxic bulky aromatic or conjugated units. Herein, a novel hyperbranched polyphosphate (HBPPE) was synthesized using triethyl phosphate (TEP) and ethylene glycol (EG) through a transesterification polycondensation reaction.

Dual Infection of Different Clusters of HIV in People Living with HIV Worldwide: A Meta-Analysis Based on Next-Generation Sequencing Studies.

To understand the global dual HIV infection (DI) profiles comprehensively, the databases Cochrane Library, Embase, PubMed, and Web of Science were the data sources up to March 31, 2024 (PROSPERO: CRD42023388328). Stata and R-language software were used to analyze the extracted data. Publication bias was assessed using Egger's test.

The change of symptom clusters in gastric cancer patients during the perioperative period: a longitudinal study.

Aim And Objectives: The purpose of this study was to describe the number, type and trajectory of symptom clusters during the perioperative period in patients with gastric cancer at four different time points. The study also aimed to identify the changes and consistency of these symptom clusters over time.

Design: This was a longitudinal study.

Regulation of Photophysical Behaviors in Hyperbranched Aggregation-Induced Emission Polymers for Reactive Oxygen Species Scavenging.

Developing nonconjugated materials with large Stokes shifts is highly desired. In this work, three kinds of hyperbranched aggregation-induced emission (AIE) polymers with tunable n/π electronic effects were synthesized. HBPSi-CBD contains alkenyl groups in the backbone and possesses a promoted n-π* transition and red-shifted emission wavelength with a large Stokes shift of 186 nm.

Involvement of GSTP1 in low dose radiation-induced apoptosis in GM12878 cells.

Background: Low-dose ionizing radiation-induced protection and damage are of great significance among radiation workers. We aimed to study the role of glutathione S-transferase Pi (GSTP1) in low-dose ionizing radiation damage and clarify the impact of ionizing radiation on the biological activities of cells.

Results: In this study, we collected peripheral blood samples from healthy adults and workers engaged in radiation and radiotherapy and detected the expression of GSTP1 by qPCR.

Rheumatoid Arthritis Patient With Neurofibromatosis Type 1: Case Report and Review of the Literature.

A 66-year-old neurofibromatosis type 1 (NF1) patient with polyarticular pain for nine years, aggravated for two days, was transferred from the Emergency Intensive Care Unit (EICU) to our rheumatology department. She was diagnosed with NF1 nine years ago by a gene mutation detection and coronary heart disease (CHD) three months ago. The patient was diagnosed with rheumatoid arthritis (RA) this time.

The Effectiveness of Symptom Management Theory in Guiding Clinical Practice-A Systematic Review.

Objective: Symptom Management Theory has been extensively used in guiding clinical practice to reduce patients' symptom burden, improve their outcomes and quality of life. However, concerning various participants, settings and methods, the effectiveness of practice and research based on the theory was inconsistent, which hindered the further implementation of this theory in clinical practice. Thus, this study aims to systematically evaluate the effectiveness of the Symptom Management Theory in guiding clinical practice.

Modulation of Deep-Red to Near-Infrared Room-Temperature Charge-Transfer Phosphorescence of Crystalline "Pyrene Box" Cages by Coupled Ion/Guest Structural Self-Assembly.

Organic cocrystals obtained from multicomponent self-assembly have garnered considerable attention due to their distinct phosphorescence properties and broad applications. Yet, there have been limited reports on cocrystal systems that showcase efficient deep-red to near-infrared (NIR) charge-transfer (CT) phosphorescence. Furthermore, effective strategies to modulate the emission pathways of both fluorescence and phosphorescence remain underexplored.

An ultra-sensitive ratiometric fluorescent thermometer based on monomer and excimer dual emission.

By leveraging natural saturated fatty acids with distinct melting points and swift reversible phase transitions, we correlated external thermal cues to monomer and excimer emissions of difluoroboron β-diketonate fluorophores. This integration yielded a ratiometric fluorescent thermometer showcasing unparalleled sensitivity and thermochromism in the physiological temperature range.

Severe immediate hypersensitivity to gadolinium contrast agent after targeted treatment in a patient with alveolar soft part sarcoma: A case report and review of literature.

Rationale: Gadolinium-based contrast agents (GBCAs), benefiting from good tolerance and safety, become the priority contrast agents in magnetic resonance imaging. Serious hypersensitivity reactions caused by GBCAs are rare, but occur occasionally. The "immune surveillance" theory proposes that lowered immune function exists in patients with malignance, which decrease the occurrence of atopy.