Publications by authors named "Hongxia Pang"
Article Synopsis
- The study explores the relationship between total antioxidant capacity (T-AOC), glutathione peroxidase (GSH-PX), and advanced oxidized protein products (AOPP) levels in patients with nasopharyngeal carcinoma (NPC) undergoing radiotherapy, focusing on the development of oral mucositis (OM).
- Researchers measured these biomarkers at various points during treatment and categorized patients into severe and non-severe OM groups to observe changes over time.
- Findings indicate that while T-AOC and GSH-PX levels temporarily increased during treatment, they decreased significantly in severe OM patients, alongside consistently rising AOPP levels, with certain risk factors identified as contributing to the severity of OM.
Background/purpose: Head and neck squamous cell carcinoma (HNSCC) is one of the most common malignant tumors. The aim of this study was to elucidate the effect of tumor microenvironment-related genes on the prognosis of HNSCC and to obtain tumor microenvironment-related genes that can predict poor prognosis in HNSCC patients.
Materials And Methods: The ESTIMATE algorithm was applied to the HNSCC transcriptomic data downloaded from the TCGA (The cancer genome atlas), and then the samples were divided into two groups: high and low immune scoring groups, and high and low basal scoring groups to screen for differentially expressed genes (DEGs) associated with poor patient outcomes.
Sarcomatoid carcinoma is a rare malignancy characterized by a combination of epithelial and sarcoma or sarcoma-like components. In this study, we reported one case of pulmonary sarcomatoid carcinoma and evaluated the safety and efficacy of apatinib, a tyrosine kinase inhibitor selectively targeting vascular endothelial growth factor receptor 2, in treating this disease. The tumor mass was detected in the left lung of a 75-year-old man and showed positive immunostaining for cytokeratin (CK) 7, CK8, smooth muscle actin, CD31, and CD34.
View Article and Find Full Text PDFEffects of Different Levels of Caregiver Training on Oral Hygiene After Stroke.
J Am Geriatr Soc
June 2016
Objectives: To investigate the effects of caregiver training on poststroke oral hygiene and to identify appropriate structures for training programs.
Design: Single-blind prospective cohort study.
Setting: Haikou, China.
Objective: To evaluate continuous improvement of portable domestic pelvic floor neuromuscular electrical stimulation on the pelvic floor function of patients with stress urinary incontinence after short-term pelvic floor electrophysiological treatment in hospital.
Methods: Totally 60 women with stress urinary incontinence were recruited for this randomized controlled trial. The control group including a total of 30 patients, only received 4 weeks pelvic floor electrophysiological treatment in the hospital.
Correlation of chronic periodontitis in tropical area and IFN-γ, IL-10, IL-17 levels.
Asian Pac J Trop Med
June 2013
Objective: To evaluate the correlation of chronic periodontitis in tropical area and IFN-γ, IL-10 and IL-17 levels.
Methods: One hundred and forty-eight patients and one hundred and thirty-two healthy control subjects were included in the study. Clinical parameters (PI, GI and PD) and GCF levels of IFN-γ, IL-10 and IL-17 were measured at baseline, week 8, week 16 and week 24 after mechanical removal of dental plaque.
Article Synopsis
- Serum response factor (SRF) and myocyte enhancer factor 2 (MEF2) are two types of MADS-box transcription factors that have unique biological functions, but their evolutionary history and DNA-binding site specifics are not well understood.* -
- Phylogenetic analyses show that while SRF and MEF2 types share significant amino acid similarities crucial for DNA binding and structure, distinct residues determine their specific DNA configurations, indicating an evolutionary divergence.* -
- Studies also reveal that MEF2 DNA-binding sites differ notably from those of SRF, and comparisons between human and mouse genomes suggest a faster evolutionary rate for SRF-related sequences in mice, including the potential for non-functional sequences to evolve into functional binding sites.*
Genes can be classified as essential or nonessential based on their indispensability for a living organism. Previous researches have suggested that essential genes evolve more slowly than nonessential genes and the impact of gene dispensability on a gene's evolutionary rate is not as strong as expected. However, findings have not been consistent and evidence is controversial regarding the relationship between the gene indispensability and the rate of gene evolution.
View Article and Find Full Text PDFStatistical distributions of optimal global alignment scores of random protein sequences.
BMC Bioinformatics
October 2005
Background: The inference of homology from statistically significant sequence similarity is a central issue in sequence alignments. So far the statistical distribution function underlying the optimal global alignments has not been completely determined.
Results: In this study, random and real but unrelated sequences prepared in six different ways were selected as reference datasets to obtain their respective statistical distributions of global alignment scores.