Precise synthesis of hollow IrCu alloy nanoparticles for hydrogenation of substituted nitroaromatics.

Hollow structured nanoparticles exhibit unique capabilities for catalytic applications; however, the accurate synthesis of these particles and a comprehensive understanding of the relationships between their structure and performance remain considerable challenges. In this work, hollow IrCu alloy nanoparticles were synthesized through chemical reduction and electrochemical post-leaching processes. The carbon-supported IrCu bimetallic nanoparticles were then evaluated for hydrogenation of various nitroaromatics.

Erratum to "Harnessing Nanotechnology for Gout Therapy: Colchicine-Loaded Nanoparticles Regulate Macrophage Polarization and Reduce Inflammation".

[This corrects the article DOI: 10.34133/bmr.0089.

Visible-Light-Induced Synthesis of Esters via a Self-Propagating Radical Reaction.

We herein disclose a visible-light-induced synthesis of aryl esters through the cross-dehydrogenative coupling of aldehydes with phenols using BrCCl, in which phenolate functions as both a substrate and a photosensitizer. This transition-metal- and photocatalyst-free visible-light-induced esterification is suitable for a wide range of substrates and gives moderate to excellent yields (up to 95%). Mechanistic studies provided evidence of a self-propagating radical reaction involving homolytic cleavage of the aldehydic C-H bond and the formation of acyl bromides.

Catalyst-Free Photooxidative N-Acylation of Azoles with Aldehydes.

A catalyst-free photochemical N-acylation of azoles with aldehydes has been developed using inexpensive BrCCl as the oxidant. This transition-metal- and photocatalyst-free amidation proceeded efficiently with a wide variety of substrates to give the corresponding N-acylazoles, including for the late modification of pharmaceutically active molecules, and on a gram-scale.

Harnessing Nanotechnology for Gout Therapy: Colchicine-Loaded Nanoparticles Regulate Macrophage Polarization and Reduce Inflammation.

Gout is a disease caused by hyperuricemia, characterized by inflammation reactions triggered by macrophage polarization. Colchicine is a commonly used drug for gout treatment, but its mechanism of action remains unclear. The aim of this study was to investigate the regulatory effect of colchicine on macrophage polarization to enhance the therapeutic effectiveness against gout inflammation.

Factor-augmented transformation models for interval-censored failure time data.

Interval-censored failure time data frequently arise in various scientific studies where each subject experiences periodical examinations for the occurrence of the failure event of interest, and the failure time is only known to lie in a specific time interval. In addition, collected data may include multiple observed variables with a certain degree of correlation, leading to severe multicollinearity issues. This work proposes a factor-augmented transformation model to analyze interval-censored failure time data while reducing model dimensionality and avoiding multicollinearity elicited by multiple correlated covariates.

Deciphering the neuroprotective mechanisms of RACK1 in cerebral ischemia-reperfusion injury: Pioneering insights into mitochondrial autophagy and the PINK1/Parkin axis.

Introduction: Cerebral ischemia-reperfusion injury (CIRI) is a common and debilitating complication of cerebrovascular diseases such as stroke, characterized by mitochondrial dysfunction and cell apoptosis. Unraveling the molecular mechanisms behind these processes is essential for developing effective CIRI treatments. This study investigates the role of RACK1 (receptor for activated C kinase 1) in CIRI and its impact on mitochondrial autophagy.

METTL14-mediated upregulation of lncRNA HOTAIR represses PP1α expression by promoting H3K4me1 demethylation in oxycodone-treated mice.

N6-methyladenosine (m6A) methylation is a vital epigenetic mechanism associated with drug addiction. However, the relationship between m6A modification and oxycodone rewarding is less well explored. Based on an open field test, the present study evaluated oxycodone rewarding using chromatin immunoprecipitation PCR, immunofluorescence, and RNA sequencing.

Aggregation-Induced Emission Phosphorescence Featured Au-Ag Coordination Polymer with a Diphosphine N-Heterocyclic Carbene Ligand for Highly Sensitive Detection of Cr(VI).

Luminescent materials with aggregation-induced emission (AIE) characteristics have been recognized as highly selective and sensitive probes for the detection of toxic metal ions in recent years. In this paper, a Au-Ag cluster-based coordination polymer [AuAg()(CN)(HO)] [, = 1,3-bis((diphenylphosphanyl)methyl)-4,5-dihydro-imidazolylidene] was prepared by in situ generation of the diphosphine N-heterocyclic carbene (PCP)-type ligand in the presence of the corresponding metal salts. Compound exhibited 530 nm phosphorescence under 380 nm excitation with a QY of 6.

A Phosphorescent P/N/S Hybrid Ligand Stabilized AuCu Complex Selectively Senses Ammonia and Amines.

Reaction of a P/N/S hybrid ligand dpppyatc (N,N-bis((diphenylphosphaneyl)methyl)-N-(pyridin-2-yl)-amino-thiocarbamide) with Au(tht)Cl (tht=tetrahydrothiophene) and [Cu(MeCN)]BF afforded cluster complex [AuCu(dpppyatc)](BF)Cl (1). Upon excitation at 480 nm, 1 emitted orange phosphorescence at 646 nm, which was red-shifted to ~698 nm selectively in the presence of ammonia or amine vapor. This chromic photoluminescent response toward ammonia was sensitive and reversible.

Modulating β-Keto-enamine-Based Covalent Organic Frameworks for Photocatalytic Atom-Transfer Radical Addition Reaction.

The atom-transfer radical addition (ATRA) reaction simultaneously forges carbon-carbon and carbon-halogen bonds. However, frequently-used photosensitizers such as precious transition metal complexes, or organic dyes have limitations in terms of their potential toxicity and recyclability. Three β-ketoenamine-linked covalent organic frameworks (COFs) from 1,3,5-triformylphloroglucinol and 1,4-phenylenediamines with variable transient photocurrent and photocatalytic activity have been prepared.

Schiff-base Polymer Immobilized Ruthenium for Efficient Catalytic Cross-coupling of Secondary Alcohols with 2-amino- and γ-aminobenzyl Alcohols to Give Quinolines and Pyridines.

A Schiff-base porous polymer has been impregnated with ruthenium trichloride for acceptor-free dehydrogenation coupling (ADC) of secondary alcohols with γ-amino- and 2-aminobenzyl alcohols to give pyridines and quinolines. This heterogenous catalyst exhibited high catalytic efficiency over repeated cycles with wide functional group tolerance.

4-Octyl Itaconate Inhibits Proinflammatory Cytokine Production in Behcet's Uveitis and Experimental Autoimmune Uveitis.

4-octyl itaconate (4-OI) is an anti-inflammatory metabolite that activates the nuclear-factor-E2-related factor 2 (NRF2) signaling. In the current work, we investigated whether 4-OI could affect the production of proinflammatory cytokines in Behcet's uveitis (BU) and experimental autoimmune uveitis (EAU). Peripheral blood mononuclear cells (PBMCs) of active BU patients and healthy individuals with in vitro 4-OI treatment were performed to assess the influence of 4-OI on the proinflammatory cytokine production.

Model-driven terahertz image reconstruction method for debonding defects in thermal barrier coatings.

A terahertz imaging system is considered to be an effective method to study the thermal barrier coating defects in gas turbine engines. However, due to the influence of the system hardware and terahertz wavelength, the imaging system has slow acquisition efficiency, low image resolution, and serious edge blur, which cannot meet the demand for defect detection. To overcome the above defects, a model-driven terahertz image reconstruction method is proposed, which uses simulation data to build datasets, reduces the dependence on experimental data, and has a good reconstruction effect on experimental images.

Ultra-Dispersed α-MoC Embedded in a Plum-Like N-Doped Carbon Framework as a Synergistic Adsorption-Electrocatalysis Interlayer for High-Performance Li-S Batteries.

The shuttle effect and sluggish redox kinetics of lithium polysulfides (LiPSs) severely hinder the scalable application of lithium-sulfurr (Li-S) batteries. Herein, the highly dispersed α-phase molybdenum carbide nano-crystallites embedded in a porous nitrogen-doped carbon framework (α-MoC @NCF) are developed via a simple metal-organic frameworks (MOFs) assisted strategy and proposed as the multifunctional separator interlayer for Li-S batteries. The inlaid MoC nanocrystals and in situ doped nitrogen atoms provide a strong chemisorption and outstanding electrocatalytic conversion toward LiPSs, whereas the unique plum-like carbon framework with hierarchical porosity enables fast electron/Li transfer and can physically suppress LiPSs shuttling.

A Multiple Stimuli-Responsive Ag/P/S Complex Showing Solvochromic and Mechanochromic Photoluminescence.

The reaction of CFCOOAg, 3-bdppmapy (,-bis(diphenylphosphanylmethyl)-3-aminopyridine) and HTZ (1,2,4-triazole-3-thiol) in CHCl/MeOH resulted in a dinuclear Ag/P/S complex [Ag(TZ)(3-bdppmapy)]·Sol (·Sol). Crystals of ·Sol converted to ·2MeOH in air at room temperature and further to under vacuum upon heating. The solid-state, room-temperature photoluminescent emission of ·Sol (510 nm) shifted to 494 nm (·2MeOH) and 486 nm ().

Heteroleptic copper(I) complexes [Cu(dmp)(N^P)]BF for photoinduced atom-transfer radical addition reactions.

Earth-abundant copper(I) coordination complexes of an imine-phosphine and a diimine have been developed as visible-light photocatalysts. Reaction of [Cu(MeCN)]BF with hetero-bidentate phosphinopyrazole (phpz) ligand RRCHNPPh (R = R = H (1a); R = H, R = Me (1b); R = H, R = Ph (1c); R = R = Me (1d)) and 2,9-dimethyl-1,10-phenanthroline (dmp) gave four heteroleptic bis-chelate Cu(I) complexes [Cu(dmp)(RRCHNPPh)]BF (R = R = H (2a); R = H, R = Me (2b); R = H, R = Ph (2c); R = R = Me (2d)) with distorted tetrahedral geometries. Complexes 2a-2d exhibited broad absorption in the visible spectrum and could facilitate photochemical intermolecular atom-transfer radical addition reactions of CBr, or CClBr, CHI to styrenes in yields up to 91% and with a broad substrate scope.

One-Dimensional Heterobimetallic Au/Ag Coordination Polymer Showing a Selective, Reversible, and Visible Vapor-Chromic Photoluminescent Response toward Methanol.

A heterobimetallic coordination polymer [Au(dppmt)(AgCl)] () incorporating an generated P-S ligand (dppmtH) was synthesized from the solvothermal reaction of Au(tht)Cl, AgCl, and dpppyatc in CHCN/CHCl (dppmtH = (diphenylphosphino)methanethiol, tht = tetrahydrothiophene, dpppyatc = ,-bis((diphenylphosphaneyl)methyl)--(pyridin-2-yl)-amino-thiocarbamide). The structure of contains a one-dimensional helical Au-Au chain in which the unique [AuAgS] cluster units are connected by [Au(dppmt)] dimers. Upon excitation at 343 nm, exhibited cyan (495 nm) phosphorescent emission at quantum yield (QY) = 22.

A pairwise pseudo-likelihood approach for regression analysis of left-truncated failure time data with various types of censoring.

Background: Failure time data frequently occur in many medical studies and often accompany with various types of censoring. In some applications, left truncation may occur and can induce biased sampling, which makes the practical data analysis become more complicated. The existing analysis methods for left-truncated data have some limitations in that they either focus only on a special type of censored data or fail to flexibly utilize the distribution information of the truncation times for inference.

A Novel Photoluminescent Ag/Cu Cluster Exhibits a Chromic Photoluminescence Response towards Volatile Organic Vapors.

A new Ag/Cu bimetallic cluster [AgCu(bdppthi)(C≡CPh)(EtOH)](ClO) (, bdppthi = ,-bis(diphenylphosphanylmethyl)-tetrahydroimidazole) exhibited strong phosphorescent (PL) emission at 644 nm upon excitation at 400 nm. Removal of the coordinated EtOH molecules in resulted in derivative , which exhibited significant red-shifted emission at 678 nm. The structure and PL of was restored on exposure to EtOH vapor.

Covalent Grafting of a Nickel Thiolate Catalyst onto Covalent Organic Frameworks for Increased Photocatalytic Activity.

Covalent organic frameworks (COFs) have recently emerged as prospective photoactive materials with noble Pt as a cocatalyst for photocatalytic hydrogen evolution. In this work, a series of SH-group-functionalized covalent organic frameworks, TpPa-1-SH-X, is prepared by reaction of p-phenylenediamine (Pa) and 1,3,5-triformylphloroglucinol (Tp) with p-NH C H SH as a modulating agent. The reaction of TpPa-1-SH-X with Ni acetylacetonate Ni(acac) gave nickel thiolate-immobilized TpPa-1 (TpPa-1-SNi-X).

The pro-inflammatory effect of triglyceride on human CD4 T cells and experimental autoimmune uveitis.

Aberrant lipid metabolism plays a role in inflammation and progression of autoimmune diseases but the definite mechanism remains unclear. In this study we investigate lipidomic profiles in Behçet's disease (BD) and the role of triglyceride (TAG) in the pathogenesis of autoimmune uveitis. Lipidomics revealed a distinct lipid metabolite profile including increased TAG metabolites in plasma of active BD patients.