Publications by authors named "Hongwen Li"
Background: Natural killer/T-cell lymphoma (NKTCL) is a highly aggressive malignancy with a dismal prognosis, and gaps remain in understanding the determinants influencing disease outcomes.
Objective: To characterise the gut microbiota feature and identify potential probiotics that could ameliorate the development of NKTCL.
Design: This cross-sectional study employed shotgun metagenomic sequencing to profile the gut microbiota in two Chinese NKTCL cohorts, with validation conducted in an independent Korean cohort.
Article Synopsis
- Placental accreta spectrum (PAS) with bladder involvement can lead to significant complications for both mothers and newborns, making accurate diagnosis essential for treatment planning.
- This study aimed to compare the diagnostic accuracy of 2D ultrasound, 3D Crystal Vue technology, and MRI in identifying PAS cases that involve the bladder.
- Results showed that specific imaging features, like bridging vessels and the obliteration of the tramline sign on Crystal Vue, were strong predictors of bladder involvement in PAS.
Two-step cluster analysis based on three-dimensional CT measurements of craniofacial structures in severe craniofacial microsomia.
J Plast Reconstr Aesthet Surg
December 2024
Article Synopsis
- - The study aimed to classify severe forms of craniofacial microsomia (CFM) by using 3D maxillofacial measurements to examine deformities in the zygomatic, temporal, and mandibular bones, as previous classifications lacked detailed information on temporomandibular joint deformities.
- - Researchers analyzed CT scans from 50 children with severe CFM, performing 3D measurements and using cluster analysis to categorize patients based on the continuity of the zygomatic arches and several other measurements.
- - Findings revealed two distinct clusters: one with continuous zygomatic arches and another with discontinuous arches, highlighting significant differences in specific measurements that may help in better treatment planning for patients needing prosthetic joints.
Article Synopsis
- This study introduces a new method for enhancing the autonomous stable tracking capabilities of electro-optical theodolites used in closed-loop systems.
- The approach utilizes a multi-sensor adaptive weighted fusion algorithm, which includes a refined error estimation formula to ensure accurate data processing and sensor state assignments.
- Experimental results show that the algorithm can quickly switch to alternative sensors during interference or failures, maintaining robustness and stability in data generation across different measurement conditions.
Article Synopsis
- Natural killer/T cell lymphoma (NKTCL) is highly aggressive, and patients with relapsed/refractory cases have poor outcomes, with ongoing research focusing on the role of Epstein-Barr virus (EBV) in this condition.
- The study found that LMP1, a protein associated with EBV, enhances NKTCL cell growth and survival by promoting aerobic glycolysis, which involves increased glucose uptake and lactate production, ultimately leading to reduced sensitivity to conventional treatments like gemcitabine.
- LMP1 affects the clinical progression of NKTCL, with higher levels correlating to worse outcomes, and its mechanism involves engaging the noncanonical NF-κB pathway, suggesting potential targets for new treatments.
Fixed-Time-Convergent Sliding Mode Control with Sliding Mode Observer for PMSM Speed Regulation.
Sensors (Basel)
February 2024
Article Synopsis
Endogenous and microbial biomarkers for periodontitis and type 2 diabetes mellitus.
Front Endocrinol (Lausanne)
December 2023
Article Synopsis
Analysis of Obstructive Sleep Apnoea in Craniofacial Microsomia Based on Polysomnography.
Cleft Palate Craniofac J
December 2023
Article Synopsis
Mesenchymal stem cells (MSCs) have shown great potential as important therapeutic tools for dental pulp tissue engineering, with the maintenance and enhancement of their stemness being crucial for successful therapeutic application and three-dimensional (3D) spheroid formation considered a reliable technique for enhancing their pluripotency. Human exfoliated deciduous tooth stem cells (SHED) were cultured in a low attachment plate to form aggregates for five days. Then, the resulting spheroids were analyzed for pluripotent marker expression, paracrine secretory function, proliferation, signaling pathways involved, and distribution of key proteins within the spheroids.
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