Publications by authors named "Hongwei Ma"

Sepsis-induced myocardial dysfunction (SIMD) is a life-threatening complication primarily driven by inflammation, yet its molecular mechanisms remain unclear. In this study, we identified significant upregulation of the mA methyltransferase METTL3 (methyltransferase-like 3), the mA reader protein YTHDF1 (YTH N6-methyladenosine RNA binding protein 1), as well as increased expression levels of USP12 (ubiquitin-specific peptidase 12), FOXO3 (forkhead box O3), and key molecules in the intrinsic apoptotic pathway, PUMA (p53 upregulated modulator of apoptosis) and BAX (Bcl-2-associated X), through proteomic profiling in an LPS (Lipopolysaccharide)-induced SIMD mouse model. In vitro and in vivo experiments demonstrated that METTL3 and YTHDF1 regulated USP12 mRNA expression and stability through mA modification.

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  • The goal of creating specific molecules in synthetic chemistry highlights the importance of cyclobutanes (CBs), known for their potential in pharmaceuticals and materials science.* -
  • The paper discusses a new method for synthesizing unique, fully substituted cyclobutanes using stiff-stilbene precursors, overcoming challenges posed by steric hindrance.* -
  • The synthesized cyclobutanes exhibit high ring-strain energies and can reversibly convert back to their precursors, suggesting potential uses in responsive and energy storage applications.*
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  • - The study focuses on exertional heat stroke (EHS), which causes central nervous system (CNS) issues and can lead to severe, possibly irreversible organ damage. An optimized model for assessing this damage is essential.
  • - Researchers induced EHS in mice using a controlled environment and assessed organ damage through various tests, finding significant damage to the liver, kidneys, and brain in EHS mice compared to a control group.
  • - The findings highlight an effective animal model for studying EHS that mirrors human clinical traits, allowing for a better understanding of neurological and organ injuries related to this condition.
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At present, China's coal mine permanent tunneling support commonly uses mechanized drilling and anchoring equipment; there are low support efficiency, labor intensity, and other issues. In order to further improve the support efficiency and liberate productivity, this paper further researches the trajectory planning of the drilling and anchoring materials of the robotic arm for the drilling machine "grasping-carrying-loading-unloading" on the basis of the drilling and anchoring robotic system designed by the team in the previous stage. Firstly, the kinematic model of the robotic arm with material was established by improving the D-H parameter method.

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When the coal gangue sorting robot sorts coal gangue, the position of the target coal gangue will change due to belt slippage, deviation, and speed fluctuations of the belt conveyor. This will cause the robotic to fail in grasping or miss grasping. We have developed a solution to this problem: the IMSSP-Net two-stage network gangue image fast matching method.

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The root of Stemona tuberosa Lour has been used to treat tuberculosis, scabies, and eczema. Polysaccharides are among its main bioactive ingredients. A low-molecular-weight (1819 Da) polysaccharide (SPS2-A) was obtained from the root of S.

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Medical Microbiology and Medical Immunology are important components of our university's the modular teaching on fundamentals of immunity and infection. Among these, Bacterial Infection and Immunity serves as a bridge between Medical Microbiology and Medical Immunology. This chapter mainly introduces how pathogenic bacteria invade the body to cause infection and how the body's immune system resists bacterial infection.

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Cone photoreceptor cyclic nucleotide-gated (CNG) channels play an essential role in phototransduction and cellular Ca homeostasis. Mutations in genes encoding the channel subunits CNGA3 and CNGB3 are associated with achromatopsia, progressive cone dystrophy, and early-onset macular degeneration. Cone loss in patients with achromatopsia and cone dystrophy associated with CNG channel mutations has been documented by optical coherence tomography and in mouse models of CNG channel deficiency.

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  • Hantavirus causes severe diseases with high mortality rates, and current treatments are lacking; however, Type I interferon has shown promise when administered early.
  • The study reveals that Hantaan virus (HTNV) increases the expression of the enzyme cholesterol 25-hydroxylase (CH25H), which then helps inhibit HTNV infection through cholesterol regulation.
  • It suggests that 25-hydroxycholesterol (25HC) and cholesterol-lowering statins could be repurposed as effective antiviral treatments against hantavirus infections, highlighting the potential of targeting cholesterol metabolism in developing new therapies.
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The roadway space of coal mine is narrow, and the illumination is low and uneven. Dynamic mining is accompanied by dust and water mist. The accuracy and reliability of roadway data collected by vision and laser sensors are poor.

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Thyroid hormone (TH) plays an essential role in cell proliferation, differentiation, and metabolism. Experimental and clinical studies have shown a potential association between TH signaling and retinal degeneration. The suppression of TH signaling protects cone photoreceptors in mouse models of retinal degeneration, whereas excessive TH signaling induces cone degeneration, manifested as reduced light response and a loss of cones.

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The Daling River Basin is an important ecological functional area in the western region of Liaoning with outstanding environmental problems. The monitoring of ecological and environmental quality in the basin and the analysis of driving factors are of great importance for the protection of the ecological environment and the improvement of economic quality. In this paper, the three periods of Landsat remote sensing images in 1995, 2010 and 2020 are used as the basic data, and platforms and technical means such as RS and GIS are used to decipher and extract the three periods of land use information, and to construct the land use type transfer matrix.

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In digital holography (DH), determining the reconstruction distance is critical to the quality of the reconstructed image. However, traditional focal plane detection methods require considerable time investment to reconstruct and evaluate holograms at multiple distances. To address this inefficiency, this paper proposes a fast and accurate autofocusing method based on an adaptive genetic algorithm.

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Ultrasonic guided wave (UGW) inspection is an emerging non-destructive testing(NDT) technique for rail flaw detection, where weak UGW signals under strong noise backgrounds are difficult to detect. In this study, a UGW signal identification model based on a chaotic oscillator is established. The approach integrates the UGW response into the critical state of the Duffing system to serve as a disturbance control variable.

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Senecavirus A (SVA) is an important emerging swine pathogen that causes vesicular lesions in swine and acute death in newborn piglets. VP2 plays a significant role in the production of antibodies, which can be used in development of diagnostic tools and vaccines. Herein, the aim of the current study was to identify B-cell epitopes (BCEs) of SVA for generation of epitope-based SVA marker vaccine.

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  • Preeclampsia is a serious pregnancy-related condition linked to improper remodeling of blood vessels in the uterus, but its early molecular causes are still not fully understood.
  • Research shows that preeclampsia is caused by underdeveloped trophoblasts and endothelial cells due to delayed epigenetic changes, leading to an excessive amount of immature trophoblast cells.
  • The study finds that high levels of a gene called PEG10, transferred from trophoblasts to maternal cells, disrupt normal blood vessel development by interfering with TGF-beta signaling, highlighting complex genetic interactions during pregnancy.
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  • The study aimed to understand how activation patterns of astrocytes relate to the progression of epidemic encephalitis B caused by the Japanese encephalitis virus (JEV) using a mouse model.
  • Researchers used various techniques, including immunofluorescence and RNA sequencing, to observe changes in astrocyte activation across different brain regions and stages of the disease.
  • Although administering irisin did not improve overall health outcomes in the mice, it was found to reduce harmful A1 astrocyte activation and lessen neuroinflammation following JEV infection.
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Persistent immunoglobulin G (IgG) production (PIP) provides long-term vaccine protection. While variations in the duration of protection have been observed with vaccines prepared from different pathogens, little is known about the factors that determine PIP. Here, we investigated the impact of three parameters on the duration of anti-peptide IgG production, namely amino acid sequences, protein carriers, and immunization programs.

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In the fields of photolithographic patterning, optical anticounterfeiting, and information encryption, reversible photochromic materials with solid-state fluorescence are emerging as a potential class of systems. A design strategy for reversible photochromic materials has been proposed and synthesized through the introduction of photoactive thiophene groups into the molecular backbone of aryl vinyls, compounds with unique aggregation-induced emission properties, and solid-state reversible photocontrollable fluorescence and color-changing properties. This work develops novel photochromic inks, films, and cellulose hydrogels for enhancing the security of information encryption and anticounterfeiting technologies.

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  • The paper addresses the challenge of assessing structural health without baseline data, a critical issue in engineering that impacts safety evaluations.
  • It presents a method that uses Variational Autoencoder neural networks to detect bridge damage, even with limited accelerometer data by optimizing model parameters for effective training.
  • The findings reveal that the proposed approach can accurately identify damage locations and conditions while being cost-effective, enhancing practical applications by reducing the need for numerous sensors.
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Chemotherapy of glioblastoma (GBM) has not yielded success due to inefficient blood-brain barrier (BBB) penetration and poor glioma tissue accumulation. Aerobic glycolysis, as the main mode of energy supply for GBM, safeguards the rapid growth of GBM while affecting the efficacy of radiotherapy and chemotherapy. Therefore, to effectively inhibit aerobic glycolysis, increase drug delivery efficiency and sensitivity, a novel temozolomide (TMZ) nanocapsule (ApoE-MT/siPKM2 NC) is successfully designed and prepared for the combined delivery of pyruvate kinase M2 siRNA (siPKM2) and TMZ.

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  • Researchers have successfully created the first octanuclear cubic structures using anion-coordination, utilizing phosphate anions and specific bis-bis(urea) ligands.
  • The structure incorporates flexible terminal aryl rings that foster the development of "aromatic pockets," allowing for binding of up to 22 cation guests, which helps stabilize the cube through cation-π interactions.
  • The resulting assemblies show varying chirality depending on the ligands used, leading to either mixed diastereomers or enantiopure cubes, suggesting that both the terminal groups and the cations can influence the cube's structure.
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  • The study investigates the pharmacological properties of polysaccharides from Lour, a plant used in Chinese herbal medicine, focusing on their extraction methods and associated bioactivities.
  • Six polysaccharides were extracted from different parts of Lour using hot water and ultrasound-assisted methods, revealing significant variations in their yields, chemical compositions, and antioxidant and anti-inflammatory activities.
  • Findings indicate that polysaccharides from the roots (SPS-R1 and SPS-R2) show promising anti-inflammatory effects, while those from the leaves (SPS-L1) have strong antioxidant properties, suggesting potential medicinal applications that require further exploration.*
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  • - The paper explores how financial constraints hinder innovation in the marine economy, introducing "capital constraints" as a key factor in the technological innovation chain involving financial institutions, marine enterprises, and academic researchers.
  • - It identifies two types of technological innovation cooperation—"cooperative tackling" and "market-oriented promotion"—and highlights the importance of collaboration between research institutions and marine enterprises for securing higher loan amounts.
  • - The study suggests that effective cooperation benefits come from higher initial willingness to innovate, while an imbalance in funding allocation can negatively affect outcomes, recommending market-oriented approaches as complementary to traditional methods and providing numerical examples and policy suggestions.
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