Significance of binocular fusion in enhancing visual acuity during amblyopia treatment.

Background: Currently, the exploration of amblyopia treatment methods is gradually shifting to the restoration of binocular visual perceptual function. Binocular fusion function, as an important component of binocular visual function, mainly reflects the patient's ability to integrate the signals received from both eyes. In this study, we investigated the relationship between binocular fusion function and improvement in visual acuity during amblyopia treatment.

Evaluation of Early Accommodation Outcomes Following Femtosecond Laser-Assisted in situ Keratomileusis and Small Incision Lenticule Extraction.

Purpose: The aim of this study is to assess the changes and differences in early postoperative binocular accommodative function following femtosecond laser-assisted in situ keratomileusis (FS-LASIK) and small incision lenticule extraction (SMILE).

Methods: In this retrospective study, 120 patients (240 eyes) diagnosed with low-to-moderate and high myopia, who underwent either FS-LASIK or SMILE procedures were included. The assessment encompassed measurements of accommodative facility, accommodation time, relaxation time, and accommodation-to-relaxation ratio using a smart flipper.

Prime Editing of Vascular Endothelial Growth Factor Receptor 2 Attenuates Angiogenesis .

Vascular endothelial growth factor receptor (VEGFR)-2 is a key switch for angiogenesis, which is observed in various human diseases. In this study, a novel system for advanced prime editing (PE), termed PE6h, is developed, consisting of dual lentiviral vectors: (1) a clustered regularly interspaced palindromic repeat-associated protein 9 (H840A) nickase fused with reverse transcriptase and an enhanced PE guide RNA and (2) a dominant negative (DN) homolog 1 gene with nicking guide RNA. PE6h was used to edit (c.

Deficits of the "Good" Eye in Amblyopia: Processing Geometric Properties.

Purpose: Although fellow eyes of amblyopia are typically considered normal, recent studies have revealed impairments in certain aspects of vision. However, it remains unclear at which level of object processing these impairments occur. This study aims to investigate the functional level of visual perception impairment in the fellow eye of children and adults with amblyopia using the geometric functional hierarchy discrimination task based on Klein Mathematics methodology.

Overcoming cancer drug-resistance calls for novel strategies targeting abnormal alternative splicing.

Abnormal gene alternative splicing (AS) events are strongly associated with cancer progression. Here, we summarize AS events that contribute to the development of drug resistance and classify them into three categories: alternative cis-splicing (ACS), alternative trans-splicing (ATS), and alternative back-splicing (ABS). The regulatory mechanisms underlying AS processes through cis-acting regulatory elements and trans-acting factors are comprehensively described, and the distinct functions of spliced variants, including linear spliced variants derived from ACS, chimeric spliced variants arising from ATS, and circRNAs generated through ABS, are discussed.

Effects of common eye diseases in children and their treatment measures on ocular surface homeostasis: A review.

Ocular surface homeostasis plays a vital role in maintaining of eye health. Dry eye disease is one of the prominent and typical manifestations of disruption of ocular surface homeostasis that leads to the worsening of ocular surface homeostasis that leads to the worsening of ocular surface disease when it interacts with other pathogenic factors. However, disruption in ocular surface homeostasis in children is often overlooked because of the current methods of assessing ocular surface homeostasis.

Thromboelastography-Guided Antiplatelet Therapy for Patients with Ischemic Cerebrocardiovascular Diseases: A Systematic Review and Meta-Analysis.

Introduction: The effectiveness of thromboelastography (TEG)-guided antiplatelet therapy in patients with ischemic cerebrocardiovascular diseases is not well-established. This systematic review evaluates the efficacy and safety of TEG-guided antiplatelet therapy compared to standard treatment in patients with ischemic cerebrocardiovascular diseases.

Methods: Randomized controlled trials (RCTs) and observational studies comparing TEG-guided antiplatelet therapy with standard therapy in patients suffering from ischemic stroke (IS) or coronary artery disease (CAD) were identified.

The optimal atropine concentration for myopia control in Chinese children: a systematic review and network Meta-analysis.

Aim: To figure out whether various atropine dosages may slow the progression of myopia in Chinese kids and teenagers and to determine the optimal atropine concentration for effectively slowing the progression of myopia.

Methods: A systematic search was conducted across the Cochrane Library, PubMed, Web of Science, EMBASE, CNKI, CBM, VIP, and Wanfang database, encompassing literature on slowing progression of myopia with varying atropine concentrations from database inception to January 17, 2024. Data extraction and quality assessment were performed, and a network Meta-analysis was executed using Stata version 14.

Effect and safety posterior scleral reinforcement on controlling myopia in children: a meta-analysis.

Purpose: The aim of this meta-analysis was to assess the efficacy of posterior scleral reinforcement (PSR) on the control of pediatric myopia. Electronic databases were systematically searched.

Methods: Standardized mean differences (SMDs) of outcomes were calculated.

GIS-based landslide susceptibility zoning using a coupled model: a case study in Badong County, China.

Landslide susceptibility zoning is necessary for landslide risk management. This study aims to conduct the landslide susceptibility evaluation based on a model coupled with information value (IV) and logistic regression (LR) for Badong County in Hubei Province, China. Through the screening of landslide predisposing factors based on correlation analysis, a spatial database including 11 landslide factors and 588 historical landslides was constructed in ArcGIS.

Hippo pathway in intestinal diseases: focusing on ferroptosis.

The incidence of intestinal diseases, such as inflammatory bowel disease, gastric cancer, and colorectal cancer, has steadily increased over the past decades. The Hippo pathway is involved in cell proliferation, tissue and organ damage, energy metabolism, tumor formation, and other physiologic processes. Ferroptosis is a form of programmed cell death characterized by the accumulation of iron and lipid peroxides.

CircRNA and Stroke: New Insight of Potential Biomarkers and Therapeutic Targets.

Stroke, the second-largest cause of death and the leading cause of disability globally, presents significant challenges in terms of prognosis and treatment. Identifying reliable prognosis biomarkers and treatment targets is crucial to address these challenges. Circular RNA (circRNA) has emerged as a promising research biomarkers and therapeutic targets because of its tissue specificity and conservation.

Measurement and analysis of water ecological carrying capacity in the Yangtze River Economic Belt, China.

Water ecological carrying capacity (WECC) is a crucial index for measuring regional sustainable development. To investigate the evolution of WECC in the Yangtze River Economic Belt (YREB), this study constructed a comprehensive index system consisting of 23 indicators from six interconnected dimensions of water systems. The back propagation neural network (BPNN) model was used to quantify WECC in YREB from 2010 to 2021, and ArcGIS was utilized to visualize the distribution of WECC.

The Influence of Parents' Background and Their Perception on the Progression of Myopia in Children.

Purpose: To study the influence of parents' educational backgrounds and understanding on the progress of myopia in their offspring.

Methods: Spherical equivalent refraction (SE) of the children (aged 6-14) in China was assessed with cycloplegic autorefraction in a two-year longitudinal study. The parents' background information and myopia-related cognition were collected by questionnaires.

The Effects of Binocular Visual Function Training after Concomitant Exotropia Surgery.

Purpose: This study investigated the effect and long-term efficacy of binocular visual function training after concomitant exotropia surgery.

Methods: A total of 92 patients who underwent concomitant exotropia surgery were randomly divided into group A (the training group) ( = 54), who received binocular four-dimensional (4D) visual function training after surgery, and group B (control group) ( = 38). The patients in group A received personalized 4D visual function training 2 weeks after surgery and were followed up for 12 months.

Research on regional water environmental carrying capacity based on GIS and TOPSIS comprehensive evaluation model.

Water environmental carrying capacity (WECC) is an important indicator for assessing the coordination between the water environment and the social-economic-resources and environment subsystems. In this study, to determine the WECC of Changsha-Zhuzhou-Xiangtan urban agglomeration in Xiang River Basin, a three-level index system was established using an analytic hierarchy process. Because the previous evaluation system lacked continuous indicators, the results could not reflect the differences of WECC within the administrative units, thus, this study selected 4 continuous indicators, and finally an evaluation index system including 15 indicators was established.

A Study on the Effectiveness of 650-nm Red-Light Feeding Instruments in the Control of Myopia.

Introduction: This study analyzed the effectiveness of 650-nm red-light feeding instruments in the control of myopia.

Methods: In this study, 164 school-aged participants diagnosed with myopia in the city of Shenzhen were enrolled in a red-light feeding instrument study. Of these, 41 were enrolled in the mild-to-moderate myopia group that received red-light feeding (RLMM group), 65 were enrolled in the mild-to-moderate myopia group that received single-vision spectacle treatment (SVSMM group), and 58 were included in the severe myopia group that received red-light feeding (RLS group).

Exploring the Relationship Between Binocular Imbalance and Myopia: Refraction with a Virtual Reality Platform.

To explore the relationship between binocular imbalance (BI) and the abnormal development of binocular refraction. BI data were collected by enrolling the first 1,000 adolescents and children aged 6-18 years in Shenzhen Eye Hospital from April 2020 to January 2021. In this cross-sectional study, the imbalance value (IV) did not show a statistical correlation with the spherical equivalent (SE) (oculus dexter [OD]:  = 0.

Experimental Study of Multi-Angle Effects of Micron-Silica Fume on Micro-Pore Structure and Macroscopic Mechanical Properties of Rock-like Material Based on NMR and SEM.

The experiment of rock-like material plays an important role in the simulation of engineering fractured rock mass. To further understand the influence of raw materials on rock-like materials, this paper carried out the indoor mechanical properties test and the micro-pore structure detection combining NMR and SEM. The effects of micron-silica fume (SF) on microporous structure parameters and macroscopic mechanical properties under different conditions of water-cement ratio (WCR) and sand-cement ratio (SCR) were discussed.

Balancing Between Polarization and Conduction Loss toward Strong Electromagnetic Wave Absorption of Hard Carbon Particles with Morphology Heterogeneity.

The heterostructure and hierarchical morphology of carbonaceous absorbents play an important role in the construction of high-performance electromagnetic wave absorbing materials. Herein, novel micron-scale hard carbon particles with morphology heterogeneity were developed as lightweight superior electromagnetic wave absorbents via a facile and ecofriendly process. The as-prepared hard carbon particle composed of pseudographite and a highly disordered region shows a unique heterostructure.

Correlation Analysis between Microscopic Pore Parameters and Macroscopic Mechanical Properties of Rock-like Materials from the Perspective of Water-Cement Ratio and Sand-Cement Ratio.

To explore the effects of water-cement ratio and sand-cement ratio on micro-pore structure characteristics and macroscopic mechanical properties and thus improve the understanding of rock-like materials, the mechanical test and detection of micro-pore structure combining NMR and SEM were carried out. The effects of WCR and SCR on different porosity parameters and mechanical properties were discussed. The correlation and internal relationship between mechanical properties and parameters of different porosities and fractal dimensions were analyzed.

Therapeutic implications of nanodrug and tissue engineering for retinal pigment epithelium-related diseases.

The retinal pigment epithelium (RPE), as a single layer of cells that performs multiple functions posteriorly in the eye, is a promising target site for the prevention and treatment of several clinical diseases, including proliferative diabetic retinopathy, age-related macular degeneration, chorionic neovascularization, and retinitis pigmentosa. In recent decades, several nanodrug delivery platforms and tissue-engineered RPE have been widely developed to treat RPE-related diseases. This work summarizes the recent advances in nanoplatforms and tissue engineering scaffolds developed in these fields.