Identifying Exifone as a Dual-Target Agent Targeting Both SARS-CoV-2 3CL Protease and the ACE2/S-RBD Interaction Among Clinical Polyphenolic Compounds.

The ongoing emergence of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) variants has led to resistance against multiple coronavirus disease 2019 (COVID-19) vaccines and therapeutic medications, making the development of effective therapeutics against SARS-CoV-2 a high priority. Studies have shown that bioactive polyphenols, particularly those with triphenol groups, can effectively inhibit the activity of SARS-CoV-2 3-chymotrypsin-like protease (3CL). However, the structural instability of polyphenols necessitates further research.

Seasonal Variations in Macrobenthos Communities and Their Relationship with Environmental Factors in the Alpine Yuqu River.

This study investigated the spatial and temporal variations of macrobenthos community structure in the Yuqu River Basin during the dry and wet seasons due to environmental factors. This study quantified the independent and interactive contributions of hydrophysical, hydrochemical, and climatic factors to the community structure through a variance decomposition analysis (VPA). The study findings indicate that during May (the dry season), factors such as water depth, flow velocity, dissolved oxygen, and air temperature exhibit relatively minor fluctuations, rendering the aquatic environment more stable than in the rainy season.

Programmed cell death 1 inhibitor sintilimab plus S-1 and gemcitabine for liver metastatic pancreatic ductal adenocarcinoma.

Background: Pancreatic ductal adenocarcinoma (PDAC) is a highly aggressive cancer with poor prognosis. When it metastasizes to the liver, treatment options become particularly limited and challenging. Current treatment options for liver metastatic PDAC are limited, and chemotherapy alone often proves insufficient.

Microstructure Manipulation Achieves Superior Efficiency of GeTe-Based Thermoelectric Modules.

GeTe has good thermoelectric performance at relatively high temperatures, but the low-symmetry structure near room temperature and phase transition limit its service stability for power generation applications. Here, the thermoelectric properties and mechanical hardness of GeTe are improved by microstructure manipulation and phase transition engineering. The incorporation of Cr, Pb, and Sb into the GeTe lattice modulates the phase transition, increasing the cubic phase fraction from 49% to 73% at 300 K.

Boron phosphide microwires based on-chip electrocatalytic oxygen evolution microdevice.

Developing low-cost, high-performance metal-free electrocatalysts is crucial for sustainable oxygen evolution reactions (OERs) in alkaline media. Here, we synthesized ultra-long boron phosphide (BP) microwires along the [111] crystal axis with high yield. By controlling temperature and adding Ni, we identified Ni's role as a flux and transport agent, optimizing BP microwires at 1050°C.

NIGWO-iCaps NN: A Method for the Fault Diagnosis of Fiber Optic Gyroscopes Based on Capsule Neural Networks.

When using a fiber optic gyroscope as the core measurement element in an inertial navigation system, its work stability and reliability directly affect the accuracy of the navigation system. The modeling and fault diagnosis of the gyroscope is of great significance in ensuring the high accuracy and long endurance of the inertial system. Traditional diagnostic models often encounter challenges in terms of reliability and accuracy, for example, difficulties in feature extraction, high computational cost, and long training time.

CDCA4 promotes bladder cancer progression by JAK/STAT signaling pathway.

Background: The cell division cycle associated 4 (CDCA4) plays a crucial role in various biological processes and is implicated in the progression of several tumors, however, the mechanisms by which it operates in bladder cancer remain unclear.

Methods: Utilizing data from the TCGA and GEO datasets of bladder cancer patients, we analyzed the expression of CDCA4 and its prognostic significance. We then constructed stable overexpression and knockdown bladder cancer cell lines to investigate the effects of CDCA4 on cell proliferation, migration, and invasion in vitro, employing CCK-8, colony formation, transwell, and wound healing assays.

Efficacy and safety of JMT103 in patients with bone metastases from solid tumors: A randomized Phase Ib clinical trial.

This study aimed to assess the efficacy and safety of three dosing regimens of JMT103 in patients with bone metastases from solid tumors. Eligible patients were randomly assigned to receive JMT103 subcutaneously, 120 mg every 4 weeks (Cohort 1), 120 mg every 8 weeks (Cohort 2), or 180 mg every 8 weeks (Cohort 3) for up to 49 weeks. The primary endpoint was change from baseline to Week 13 in creatinine-adjusted urinary N-telopeptide (uNTx/Cr).

Interleukin-33 modulates NET formation via an autophagy-dependent manner to promote neutrophilic inflammation in cigarette smoke-exposure asthma.

Cigarette smoke (CS) contributes to IL---33 release and neutrophil inflammation in asthma. Neutrophil extracellular traps (NETs) are essential for neutrophil function. However, the effect of IL--33 on neutrophils in cigarette smoke--exposure asthma remains unclear.

A case report of S1-S3 sacroiliac screw fixation for posterior pelvic ring injury with S1 sacral dysmorphism.

Introduction: There are few reports on the treatment of pelvic posterior ring injury with Sacral 1 - Sacral 3(S1-S3)sacroiliac screw fixation. This article reports a case of pelvic posterior ring injury with S1 sacral dysmorphism treated with S1-S3 sacroiliac screw fixation and reviews the relevant research progress.

Presentation Of The Case: A 72-year-old man riding e-bike was struck by a car at a high speed and diagnosed with pelvic fracture.

Clinical study on the effect of jejunoileal side-to-side anastomosis on metabolic parameters in patients with type 2 diabetes.

Background: At present, the existing internal medicine drug treatment can alleviate the high glucose toxicity of patients to a certain extent, to explore the efficacy of laparoscopic jejunoileal side to side anastomosis in the treatment of type 2 diabetes, the report is as follows.

Aim: To investigate the effect of jejunoileal side-to-side anastomosis on metabolic parameters in patients with type 2 diabetes mellitus (T2DM).

Methods: We retrospectively analyzed the clinical data of 78 patients with T2DM who were treated jejunoileal lateral anastomosis.

Optoelectronic array of photodiodes integrated with RRAMs for energy-efficient in-sensor computing.

The rapid development of internet of things (IoT) urgently needs edge miniaturized computing devices with high efficiency and low-power consumption. In-sensor computing has emerged as a promising technology to enable in-situ data processing within the sensor array. Here, we report an optoelectronic array for in-sensor computing by integrating photodiodes (PDs) with resistive random-access memories (RRAMs).

Alpha-lipoic acid targets expression to inhibit cervical cancer progression.

It is unclear what part KLF7 plays in cervical cancer. In this study, immunohistochemical and bioinformatics analyses reveal that KLF7 expression is lower in normal cervical tissues than in cervical cancer tissues, and the high level of transcripts in cervical cancer tissues is negatively correlated with patients' overall and disease-free survival. In addition, KLF7 overexpression facilitates the proliferation, migration, and invasion of cervical cells, reduces PFKL expression, and increases the expressions of , , , , , and .

Exploring the multifaceted challenges of gastrointestinal metastases in lung adenocarcinoma: a case report highlighting diagnostic dilemmas and therapeutic innovations.

Background: Lung cancer, the primary cause of cancer-related deaths, often metastasizes early, commonly affecting the liver, brain, bones, and adrenal glands. Although gastrointestinal (GI) metastasis is rare, it poses significant diagnostic and therapeutic challenges and is frequently linked to severe complications.

Case Description: We present a case of a 61-year-old male with a history of lung cancer who presented with intestinal obstruction.

Exploring bifunctional molecules for anti-SARS-CoV-2 and anti-inflammatory activity through structure-based virtual screening, SAR investigation, and biological evaluation.

As new variants of the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) continue to emerge, they raise increasing concerns about the efficacy of neutralizing antibodies and vaccines. This situation underscores the urgent need for specific drugs against the coronavirus disease 2019 (COVID-19). Given that COVID-19 is particularly associated with substantial inflammation, the development of novel, effective antiviral and anti-inflammatory agents represents a promising research direction.

Characterization of Spirobisnaphthalenes from an Endophytic Fungus sp. Associated with and Insights into Their Biological Activity.

Fungal secondary metabolites have been increasingly sought after as an alternative strategy to herbicides and a source of new medicines. Twenty spirobisnaphthalenes (SBNs) were isolated from the fermentation broth of sp. YUD20003 from the herb (L.

Development of a high-voltage power supply with ultra-low ripple of beam current on electron beam gun.

Electron beam guns with grid-controlled electrodes and hot-cathodes are widely used in accelerator physics facilities, high-voltage electron beam welding machines, electron beam 3D additive manufacturing, x-ray sources, etc. The ripple of electron beam current is one of the most critical factors affecting beam quality, and the electron beam current ripple is generally more than 2% with traditional circuit topology. This paper presents the expression for beam current, high voltage, and bias voltage derived from experimental data on a certain electron beam gun.

Color tunable inverted pyramid micro-LEDs based on nano-patterned sapphire substrates.

Color-tunable micro-scale light-emitting diodes (Micro-LEDs) can achieve full-color display in a simple and low-cost way. In this paper, we demonstrate growth of three-dimensional (3D) inverted pyramid GaN on nano-patterned sapphire substrates (NPSS). By using the sputtered AlN nucleation layer, the uniformity of the inverted pyramid has been improved to a large extent.

Discovery of Chalcone Derivatives as Bifunctional Molecules with Anti-SARS-CoV-2 and Anti-inflammatory Activities.

Danshensu extracted with traditional Chinese medicine has a wide range of bioactivities. Danshensu containing a catechol moiety has a moderate inhibitory effect on SARS-CoV-2 3CL (IC = 2.2 μM) by a reversible covalent interaction and exhibits good anti-inflammatory activity.

Multioxidized polyketides from an endophytic Penicillium sp. YUD17006 associated with Gastrodia elata.

Three novel, highly oxygenated polyketides, multioketides A-C (1-3), and three previously described multioxidized aromatic polyketides (4-6), were isolated from an endophytic Penicillium sp. YUD17006 associated with Gastrodia elata. Their chemical structures were elucidated using extensive spectroscopic data, electronic circular dichroism calculations, and single X-ray diffraction analysis.