Publications by authors named "Hongsong Li"

The sturgeon is an important commercial aquaculture species in China. The measurement of sturgeon mass plays a remarkable role in aquaculture management. Furthermore, the measurement of sturgeon mass serves as a key phenotype, offering crucial information for enhancing growth traits through genetic improvement.

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Objective: To investigate the potential treatments for aortic stenosis and severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) using bioinformatics and systems biology.

Study Design: Observational study. Place and Duration of the Study: Jiading District Central Hospital affiliated Shanghai University of Medicine & Health Sciences, Shanghai, China, from August to December 2022.

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To improve the accuracy and efficiency of fish behavior assessment, this paper focuses on quantitatively exploring the variations and relationships between different monitoring dimensions. A systematic comparison was conducted between 3D and 2D behavioral factors using an infrared tracing system, during both day and night. Significant differences in swimming distance were observed among the different monitoring methods, as determined by two-way ANOVA and Tukey's test.

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The colorimetric conversion of wide-color-gamut cameras plays an important role in the field of wide-color-gamut displays. However, it is rather difficult for us to establish the conversion models with desired approximation accuracy in the case of wide color gamut. In this paper, we propose using an optimal method to establish the color conversion models that change the RGB space of cameras to the XYZ space of a CIEXYZ system.

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. Medical image segmentation is significantly essential to assist clinicians in facilitating a quick and accurate diagnoses. However, most of the existing methods are still challenged by the loss of semantic information, blurred boundaries and the huge semantic gap between the encoder and decoder.

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Macrophage migration inhibitory factor (MIF), a multifunctional cytokine, is secreted by various cells and participates in inflammatory reactions, including innate and adaptive immunity. There are some evidences that MIF is involved in many vitreoretinal diseases. For example, MIF can exacerbate many types of uveitis; measurements of MIF levels can be used to monitor the effectiveness of uveitis treatment.

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Foreign object damage (FOD) is a common mode of failure in high-speed rotating machinery, such as aircraft engines. Therefore, research on FOD is crucial for ensuring blade integrity. FOD induces residual stress on the surface and within the blade, impacting its fatigue strength and service life.

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In order to realize colorimetric characterization for the wide-color-gamut camera, we propose using the multilayer artificial neural network (ML-ANN) with the error-backpropagation algorithm, to model the color conversion from the RGB space of camera to the space of the CIEXYZ standard. In this paper, the architecture model, forward-calculation model, error-backpropagation model, and the training policy of the ML-ANN were introduced. Based on the spectral reflectance curves of the ColorChecker-SG blocks and the spectral sensitivity functions of the RGB channels of typical color cameras, the method of producing the wide-color-gamut samples for the training and testing of the ML-ANN was proposed.

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Aim: Pirfenidone (PFD), an antifibrotic drug, has various beneficial functions such as antioxidant, antifibrotic, and anti-inflammatory effects. This study aimed to explore the molecular mechanisms underlying how PFD modulates retinal pigment epithelial (RPE) cells involved in neovascularization and subretinal fibrosis.

Methods: ARPE-19 cell lines were treated with transforming growth factor-beta 2 (TGF-2) alone or in combination with PFD.

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Background: Percutaneous coronary intervention (PCI) is a safe and effective therapy for patients with obstructive coronary artery disease (CAD). We aimed to assess the correlation between the success rate of angiography and the maximum insertion length and resistance of a soft-tipped guidewire.

Methods: Five hundred twenty-one patients were treated by successful radial artery puncture.

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Article Synopsis
  • A protein trap library using gene-break transposon (GBT) in zebrafish was created to help in understanding the genetic factors involved in human diseases, particularly heart rhythm disorders like sick sinus syndrome (SSS).
  • The study screened 609 GBT lines, resulting in 35 zebrafish insertional cardiac (ZIC) mutants that express cardiac-related genes, and three of these mutants showed SSS-like symptoms.
  • Further analysis of one specific arrhythmogenic mutant revealed a new gene associated with SSS, highlighting its expression in sinus node pacemaker cells and its relationship with another cardiac gene, HCN4.
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Diabetic retinopathy (DR) is currently considered to be one of the most common diseases that cause blindness. However, DR grading methods are still challenged by the presence of imbalanced class distributions, small lesions, low accuracy of small sample classes and poor explainability. To address these issues, a resampling-based cost loss attention network for explainable imbalanced diabetic retinopathy grading is proposed.

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Purpose: The damage of hyperglycemia to the retinal pigment epithelial (RPE) cells is a critical event in diabetic retinopathy (DR). Procyanidin (PC), a kind of polyphenol compounds, has shown to be effective in preventing and treating diabetes as well as its complications, in which autophagy disorder is involved in the pathological mechanism. However, it remains unclear whether PC can play a protective role in DR by regulating the autophagy of RPE.

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Activation of Tenon's capsule fibroblasts limits the success rate of glaucoma filtration surgery (GFS), the most efficacious therapy for patients with glaucoma. Angiotensin type 1 receptor (AGTR1) is involved in tissues remodeling and fibrogenesis. However, whether AGTR1 is involved in the progress of fibrogenesis after GFS is not fully elucidated.

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Diabetic retinopathy (DR) is a common diabetic complication known to cause vision impairment and blindness. Previous studies have demonstrated that proanthocyanidins (PACs), polyphenols that are naturally found in several plants and fruits, have powerful antioxidant and anti-inflammatory effects on various cells. However, the effects and underlying mechanism of PACs against DR pathogenesis remain unknown.

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Aim: To observe the role and mechanism of autophagy in retinal pigment epithelial cell (RPE) damaged by high glucose, so as to offer a new idea for the treatment of diabetic retinopathy (DR).

Methods: ARPE-19, a human RPE cell line cultured was divided into the normal control (NC), autophagy inhibitor 3-methyladenine (3-MA), high-glucose (HG), and HG+3-MA groups. Cell viability was detected by CCK-8 assay and the apoptosis rate was measured by flow cytometry.

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In the process of oilfield wastewater treatment, the polymer-modified materials with special wettability have been recognized by many scholars for their high filtration efficiency and good adsorption effect. In this paper, we used micro-computed tomography scanning and infrared scanning technology to further explore the internal structure and surface chemistry of polyurethane modified materials and then established an experimental platform for the filtration performance of polyurethane modified materials. The change of suspended solids concentration and oil content in the sewage was tested under different filtration rate, filter layer thickness, and water quality.

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Background: Anemia caused by left ventricular outflow tract obstruction in patients with hypertrophic obstructive cardiomyopathy (HOCM) has been reported, however, large clinical studies confirming this association are lacking. The objective of the present study was to investigate the relationship between left ventricular outflow tract (LVOT) pressure gradient and hemoglobin in patients with hypertrophic cardiomyopathy (HCM).

Methods: Patient demographics, laboratory and echocardiography data from 310 patients diagnosed with HCM from our hospital who had undergone echocardiography from July 2014 to March 2019 were collected from medical records.

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Article Synopsis
  • The adult zebrafish is a valuable model for researching cardiovascular diseases due to its similar heart rate to humans and powerful genetics.
  • A new protocol was developed to measure electrocardiograms in adult zebrafish, identifying methods for probe placement, microsurgery, and anesthesia.
  • The research established a criterion for defining sinus arrest episodes, revealing that 5% of wild-type zebrafish show signs of sinus arrest, increasing to 25% in older fish, and highlighting the zebrafish's potential to model aging-related heart rhythm disorders.
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Rationale: Hallermann-Streiff syndrome (HSS) is a rare congenital disorder characterized by craniofacial malformations, sparse hair, degenerative skin changes, eye abnormalities, dental defects, and proportionate short stature.

Patient Concerns: A 24-year-old Chinese male patient presented to the ophthalmologist because of his sore eye and blurred vision.

Diagnoses: The final diagnosis of presented case is HSS having the main features of the syndrome, however, associated with uncommon ocular features, ultrasound biomicroscopy (UBM) and optical coherence tomography (OCT)changes, including aphakia, glaucoma, long eye axes, cilliary abnormalities, and chorioretinal atrophy.

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Aims: Histone deacetylase inhibitors (HDACis) are promising anticancer drugs that open new areas of epigenetic drug discovery. Multiple myeloma (MM) is a malignant tumor of the blood system that is difficult to cure and often relapses. Here, we investigated the in vitro effects of a novel HDACi, LMK-235, on MM cells, and explored the underlying mechanisms.

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Developing an ultraviolet (UV) imaging spectrometer is challenging due to a low level of incident power of photon flux, large chromatic aberration, and relatively low quantum efficiency of imaging sensor in UV waveband. In this paper, a large-aperture UV (250~400 nm) Fourier transform imaging spectrometer is presented for close-range hyperspectral sensing with high spatial resolution and decent spectral resolution. An advanced design based on a modified solid Sagnac interferometer working in UV waveband of 250~400 nm is introduced to improve the interferometric stability.

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Accumulating evidence demonstrated that abnormal expression of long non-coding RNAs (lncRNAs) was closely associated with cancer development including retinoblastoma (RB). LncRNA X inactive specific transcript (XIST) has been found to function as an oncogene or a tumor suppressor in several cancers. However, the role and underlying mechanism of XIST in RB have not been clarified.

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In this work, we present a close-range ultraviolet imaging spectrometer with high spatial resolution, and reasonably high spectral resolution. As the transmissive optical components cause chromatic aberration in the ultraviolet (UV) spectral range, an all-reflective imaging scheme is introduced to promote the image quality. The proposed instrument consists of an oscillating mirror, a Cassegrain objective, a Michelson structure, an Offner relay, and a UV enhanced CCD.

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The present study aimed to investigate the key genes and microRNAs (miRNA/miRs) associated with coronary artery disease (CAD) progression. The gene expression profile of GSE20680 and GSE12288, and the miRNA expression profile of GSE28858 were downloaded from the gene expression omnibus database. The differentially expressed genes (DEGs) in GSE20680 and GSE12288, and the differentially expressed miRNAs in GSE28858 were screened using the limma package in R software.

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