The highly hazardous veterinary drug "maduramicin" and its toxicokinetics in rats.

Background: Maduramicin (MAD) is an anticoccidial veterinary drug, but it frequently causes fatal poisonings in poultry, livestock, or humans. However, there is no specific antidote or guidance on first aid for MAD poisoning.

Aim: The aim of the present study is to evaluate the acute toxicity and toxicokinetics of MAD after oral exposure, so as to make a foundation for developing diagnostic and therapeutic protocols for human intoxication.

Design and characteristic analysis of micro multi-core fiber vibration sensor.

We proposed and fabricated a miniaturized multi-core fiber grating vibration sensor. The size of the miniaturized vibration sensor is 10mm × 10mm × 10 mm with a mass of only 0.25g.

Two Photosensitive Dermatitis Outbreaks Caused by - Chuxiong Yi Autonomous Prefecture, Yunnan Province, China, 2023.

What Is Already Known About This Topic?: () is a species of toxic mushroom known to induce symptoms of photosensitive dermatitis.

What Is Added By This Report?: In the months of May and June 2023, a total of four patients in Chuxiong Yi Autonomous Prefecture, Yunnan Province, were affected by poisoning, occurring over two distinct incidents. The condition of two patients deteriorated after they were re-exposed to sunlight on the seventh day following the initial poisoning.

Mushroom Poisoning Outbreaks - China, 2023.

What Is Already Known About This Topic?: Mushroom poisoning poses a significant food safety concern in China, with a total of 196 species identified in poisoning incidents by the end of 2022.

What Is Added By This Report?: In 2023, the China CDC conducted an investigation into 505 cases of mushroom poisoning spanning 24 provincial-level administrative divisions. This investigation resulted in 1,303 patients and 16 deaths, yielding a case fatality rate of 1.

Food-Borne Poisoning Accident from Amanitin Toxin in Wild Mushrooms - Xingtai City, Hebei Province, China, 2023.

What Is Already Known About This Topic?: Fatal poisonings caused by wild mushrooms containing amanita toxins pose a significant threat in the southern regions of China. These toxins primarily induce gastrointestinal symptoms initially, which are then followed by potentially life-threatening acute liver damage.

What Is Added By This Report?: This report contributes to the existing knowledge on these cases of poisoning by documenting the second occurrences in Hebei Province and the first occurrences in Xingtai City.

Mushroom Poisoning Outbreaks - China, 2022.

What Is Already Known About This Topic?: Mushroom poisoning is one of the most serious food safety issues in China. By the end of 2021, over 520 poisonous mushrooms had been discovered in China. The Southwest region of China was the most severely affected.

Meta-Analysis of the Prevalence of in Cattle in China.

can cause giardiasis and infect a variety of hosts. So far, there have been no detailed data regarding the positive rate of in cattle in China. Here, a systematic literature review was carried out to investigate the epidemiology of bovine in China.

Mushroom Poisoning Outbreaks - China, 2021.

What Is Already Known About This Topic?: Mushroom poisoning is one of the most serious food safety issues in China. Most poisoning incidents resulted from eating mushrooms causing gastroenteritis and psycho-neurological disorder from which patients usually could fully recover. Most deaths resulted from species causing acute liver failure and rhabdomyolysis, and the remaining deaths were attributed to acute renal failure and hemolysis.

Mushroom Poisoning Outbreaks - China, 2020.

Summary: Acute liver failure, rhabdomyolysis, acute renal failure, and hemolysis caused by poisonous mushrooms are the most important mushroom poisoning threats to the Chinese population. The most notorious lethal mushrooms are the species from genera , , and that cause acute liver failure, and that leads to rhabdomyolysis.

Unlabelled: In 2020, the total number of investigations reached 676, involving an estimated 102 species of poisonous mushrooms, 24 of which were newly recorded in China.

A Poisoning Outbreak Caused by - Chongqing Municipality, December 2020.

belongs to the Fabaceae family and is widely distributed in the southern China. It is toxic for the rotenone contained in its roots and seeds, and ingesting its seeds could result in poisoning. In December, 2020, a poisoning from plant seeds occurred in Chongqing Municipality.

Poisonings Caused by Wild Mushroom Containing Amanitin Toxins - Shaoxing City, Zhejiang Province, China, 2019.

Among all food poisoning, poisonings caused by wild mushrooms containing amanitin toxins have the highest case fatality rate. Amanitin toxins can cause acute liver function damage, and symptoms of the poisoning can include vomiting and diarrhea in early stages and progressive liver damage 2-3 days later. Before 2019, there were about 1-2 cases of wild mushroom containing amanitin toxins poisoning each year in Zhejiang Province.

Mushroom Poisoning Outbreaks - China, 2019.

Mushroom poisoning is becoming one of the most serious food safety issues in China, which is responsible for nearly a half of all oral poisoning deaths. In China, many mushrooms were previously "recorded" as poisonous. In this study, about 70 species obtained from mushroom poisoning incidents including several new records were confirmed accurately by morphological and molecular evidence in 2019, and spatial and temporal distribution characters of 13 lethal mushrooms were summarized systematically.

Utility of brain CT for predicting delayed encephalopathy after acute carbon monoxide poisoning.

Delayed encephalopathy after acute carbon monoxide poisoning (DEACMP) is a serious complication that occurs several days or weeks after carbon monoxide (CO) intoxication. This study identified computed tomography (CT) findings in the prediction of DEACMP development. Adults with CO poisoning admitted to Beijing Chaoyang Hospital, Shenyang Ninth People's Hospital, Shanxi Second People's Hospital and Shandong Provincial Hospital in China from January 2013 to January 2016 were retrospectively analyzed.

A case study of Lepiota brunneoincarnata poisoning with endoscopic nasobiliary drainage in Shandong, China.

The most frequently reported fatal Lepiota ingestions are due to L. brunneoincarnata. We present a case of L.

Effect of Biliary Drainage on the Toxicity and Toxicokinetics of in Beagles.

Amatoxin poisoning induces delayed-onset acute liver failure, which are responsible for more than 90% of deaths in mushroom poisoning. It has been postulated from animal and human studies that biliary drainage interrupting enterohepatic amatoxin circulation may affect amatoxin poisoning. Dogs were randomly divided into four groups of six animals each.

[The rabbit experimental study for toxicokinetics of chlorpyrifos impacted by hemoperfusion].

Objective: To investigate toxicokinetic parameters impacted by hemoperfusion after oral chlorpyrifos exposure, to investigate the adsorption effect of hemoperhusion for chlorpyrifos poisoning.

Methods: 12 rabbits were divided into two groups after oral exposure with chlorpyrifos 300 mg/kg body weight. Control group: without hemoperfusion; hemoperfusion group: hemoperfusion starts 0.

[Effect of acetamide on histopathology in cerebral cortex of rats with tetramine poisoning].

Objective: To observe the effect of different doses of acetamide on the histopathology in the cerebral cortex of rats with tetramine (TET) poisoning and to provide a basis for the treatment of fluoroacetamide poisoning with acetamide.

Methods: Eighty clean Sprague-Dawley rats were randomly divided into five groups: saline control group,dimethylsulfoxide water solution control group,TET poisoning group, acetamide (2.88 g/kg/d) treatment group, and acetamide (5.

[Impact of the waist circumference change on new onset of diabetes in the population with impaired fasting glucose].

Objective: To explore the impact of the waist circumference change on new onset diabetes (NOD) in the impaired fasting glucose (IFG) population.

Methods: A total of 12 657 subjects who took part in the health examination from 2006 to 2007 and from 2010 to 2011 from the employees of Kailuan Group and met the inclusion criteria were selected as the observation cohort.Of the 12 657 subjects, 10 697 were male, 1960 were female, with age of (49.

[Therapeutic effects of epidermal growth factor (EGF) combined with plasma cryoprecipitate (CRYO) on the corneal injury induced by paraquat].

Objective: To evaluate the therapeutic effects of epidermal growth factor (EGF) combined with plasma cryoprecipitate (CRYO) on the corneal injury induced by paraquat (PQ).

Methods: According to the "Toxicological test methods of pesticides for registration" (GB 15670-1995), the conjunctival sacs of 18 health New Zealand rabbits were exposed to 100 µl 20% PQ, which were randomly divided into EGF, CRYO and EGF plus CRYO groups. The routine treatments (normal saline washing and antibiotic eyedrops) were administrated to the injured eyes of 3 groups, at the same time the left eyes of 3 groups were treated with EGF, CRYO and EGF plus CRYO, respectively.