KLF2 controls the apoptosis of neutrophils and is associated with disease activity of systemic lupus erythematosus.

Background: Neutropenia is more common in patients with systemic lupus erythematosus (SLE) and is a major cause of life-threatening infections. The increased apoptosis of neutrophils is likely to be an essential cause of neutropenia in SLE. However, the detailed mechanisms of increased neutrophil apoptosis in SLE remain unknown.

Downregulated YTHDF2 expression in systemic lupus erythematosus is associated with inflammatory and neutrophil cytokine production.

Objectives: An increasing body of evidence suggests that N6-methyladenosine (m6A) plays a crucial role in the etiology of SLE. We focused on YTHDF2 expression in neutrophils and the relationship between YTHDF2 and the pathogenesis of SLE.

Methods: Sixty-one patients with SLE and 48 healthy controls (HC) were recruited, and their clinical characteristics were recorded.

Using combination of albumin to fibrinogen ratio and prognostic nutritional index model for predicting disease activity in patients with systemic lupus erythematosus.

Systemic lupus erythematosus (SLE) is chronic autoimmune disease with multiple organ damage and is associated with poor prognosis and high mortality. Identification of universal biomarkers to predict SLE activity is challenging due to the heterogeneity of the disease. This study aimed to identify the indicators that are sensitive and specific to predict activity of SLE.

Impact of Minerals and Sealing Systems on the Pore Characteristics of the Qiongzhusi Formation Shale in the Southern Sichuan Basin.

The characteristics, distribution, and preservation of pores are vital in controlling the storage and distribution of shale gas. The Qiongzhusi Formation shales taken from different members with similar tectonic and thermal evolutions were used to evaluate the response of pore characteristics to minerals and sealing systems using field-emission scanning electron microscopy and gas adsorption. Because of differences in mineral structure and arrangement, feldspar, organic matter (OM)-clay, OM-rutile, and OM-apatite aggregates facilitate multiple types of pores in the shale and influence the relative proportions of surface porosity for different types of pores owing to differences in mineral structure and arrangement.

[Chemical Species of PM2.5 in the Urban Area of Beijing].

From August 2012 to July 2013, 220 groups of PM2.5 samples were continuously collected at four locations in the urban area of Beijing (Shijingshan, Chegongzhuang, Dongsi, and Tongzhou), and the primary chemical species of PM2.5 were analysed by the chemical mass balance method.