Investigating Flood Risks of Rainfall and Storm Tides Affected by the Parameter Estimation Coupling Bivariate Statistics and Hydrodynamic Models in the Coastal City.

The public health risk caused by urban floods is a global concern. Flood risks are amplified by the interaction of rainfall and storm tides in coastal cities. In this study, we investigate the flood risks of rainfall and storm tides coupling statistical and hydrodynamic models and evaluate the influence of different parameter estimation methods and bivariate return periods (RPs) on flood risks in the coastal city.

Joint Risk of Rainfall and Storm Surges during Typhoons in a Coastal City of Haidian Island, China.

Public health risks from urban floods are a global concern. A typhoon is a devastating natural hazard that is often accompanied by heavy rainfall and high storm surges and causes serious floods in coastal cities. Affected by the same meteorological systems, typhoons, rainfall, and storm surges are three variables with significant correlations.

Kidney stones: an update on current pharmacological management and future directions.

Introduction: Kidney stones are a common problem worldwide with substantial morbidities and economic costs. Medical therapy reduces stone recurrence significantly. Much progress has been made in the last several decades in improving therapy of stone disease.

Functional effects of nonsynonymous polymorphisms in the human TRPV1 gene.

The prototypical member of the vanilloid-responsive-like subfamily of transient receptor potential (TRP) channels is TRPV1. TRPV1 mediates aspects of nociception and neurogenic inflammation; however, new roles are emerging in sensation of both luminal stretch and systemic tonicity. Although at least six nonsynonymous polymorphisms in the human TRPV1 gene have been identified, there has been no systematic investigation into their functional consequences.

Glycosylation of the osmoresponsive transient receptor potential channel TRPV4 on Asn-651 influences membrane trafficking.

We identified a consensus N-linked glycosylation motif within the pore-forming loop between the fifth and sixth transmembrane segments of the osmoresponsive transient receptor potential (TRP) channel TRPV4. Mutation of this residue from Asn to Gln (i.e.

EphA2: expression in the renal medulla and regulation by hypertonicity and urea stress in vitro and in vivo.

EphA2, a member of the large family of Eph receptor tyrosine kinases, is highly expressed in epithelial tissue and has been implicated in cell-cell and cell-matrix interactions, as well as cell growth and survival. Expression of EphA2 mRNA and protein was markedly upregulated by both hypertonic stress and by elevated urea concentrations in cells derived from the murine inner medullary collecting duct. This upregulation likely required transactivation of the epidermal growth factor (EGF) receptor tyrosine kinase and metalloproteinase-dependent ectodomain cleavage of an EGF receptor ligand, based on pharmacological inhibitor studies.

Renal expression of osmotically responsive cation channel TRPV4 is restricted to water-impermeant nephron segments.

TRPV4, a nonselective cation channel of the transient receptor potential (TRP) family, is gated by hypotonicity. Expression of TRPV4 mRNA has been detected in the circumventricular organs of the brain responsible for sensing systemic tonicity and in the kidney distal convoluted tubule (DCT), among other sites. No analysis of TRPV4 expression at the protein level has been undertaken and no systematic analysis of expression of this channel has been reported in the kidney.

Regulation of a transient receptor potential (TRP) channel by tyrosine phosphorylation. SRC family kinase-dependent tyrosine phosphorylation of TRPV4 on TYR-253 mediates its response to hypotonic stress.

The recently identified transient receptor potential (TRP) channel family member, TRPV4 (formerly known as OTRPC4, VR-OAC, TRP12, and VRL-2) is activated by hypotonicity. It is highly expressed in the kidney as well as blood-brain barrier-deficient hypothalamic nuclei responsible for systemic osmosensing. Apart from its gating by hypotonicity, little is known about TRPV4 regulation.

Urea signalling to immediate-early gene transcription in renal medullary cells requires transactivation of the epidermal growth factor receptor.

Signalling by physiological levels of urea (e.g. 200 mM) in cells of the mammalian renal medulla is reminiscent of activation of a receptor tyrosine kinase.