Nucleoporins cooperate with Polycomb silencers to promote transcriptional repression and repair at DNA double strand breaks.

DNA Double-strand breaks (DSBs) are harmful lesions and major sources of genomic instability. Studies have suggested that DSBs induce local transcriptional silencing that consequently promotes genomic stability. Several factors have been proposed to actively participate in this process, including ATM and Polycomb repressive complex 1 (PRC1).

OTUD5 limits replication fork instability by organizing chromatin remodelers.

Proper regulation of replication fork progression is important for genomic maintenance. Subverting the transcription-induced conflicts is crucial in preserving the integrity of replication forks. Various chromatin remodelers, such as histone chaperone and histone deacetylases are known to modulate replication stress, but how these factors are organized or collaborate are not well understood.

An unconventional outer-to-inner synthesis strategy for core (Au)-shell nanostructures with photo-electrochemical enhancement.

In this work, an outer-to-inner strategy is demonstrated to simultaneously fabricate core-shell NPs and assemble them onto a scaffold. Specifically, the shell material is deposited onto the scaffold first, and then a layer of the core material (Au) is covered on the shell surface. Finally, the core (Au)-shell nanoparticles (NPs) are formed on the scaffold after annealing.