Publications by authors named "Hongrui Ping"
Article Synopsis
- * Folate-functionalized cholesterol was used to create liposomes that contained curcumin (CUR), which showed effective release in the presence of colonic enzymes and was capable of reaching immune cells called macrophages.
- * In tests on mice with induced colitis, this new drug delivery system led to significant improvements in reducing inflammation, repairing mucosal tissue, and achieving better drug accumulation in the colon, suggesting it could be an effective oral treatment for UC.
Background: The enzymes involved in the 2-C-methyl-d-erythritol 4-phosphate (MEP) pathway are attractive targets of a new mode of action for developing anti-infective drugs and herbicides, and inhibitors against 1-deoxy-d-xylulose 5-phosphate reductoisomerase (IspC), the second key enzyme in the pathway, have been intensively investigated; however, few works are reported regarding IspC inhibitors designed for new herbicide discovery.
Results: A series of fosmidomycin (FOS) analogs were designed with nitrogen-containing linkers replacing the trimethylene linker between the two active substructures of FOS, phosphonic acid and hydroxamic acid. Synthesis followed a facile three-step route of sequential aza-Michael addition of α-amino acids to dibenzyl vinylphosphonate, amidation of the amino acid carboxyl with O-benzyl hydroxylamine, and simultaneous removal of the benzyl protective groups.