[Comparison of active ingredients and protective effects of Dendrobium huoshanense of different growth years on acute liver injury].

The differences of the active ingredients in Dendrobium huoshanense of different growth years and their protective effects on acute liver injury were studied to provide evidence for optimizing harvest time. The contents of polysaccharides, total flavonoids and total alkaloids in D. huoshanense of different growth years were determined by UV spectrophotometry, and the contents of gigantol in D.

Gene Knockout Reduces the Metabolism and Efficacy of Venlafaxine in Rats.

Rat has been considered as an ortholog of human To assess the role of CYP2D1 in physiologic processes and drug metabolism, a -null rat model was generated with a CRISPR/Cas9 method. Seven base pairs were deleted from exon 4 of of Sprague-Dawley wild-type (WT) rats. The -null rats were viable and showed no abnormalities in general appearance and behavior.