HOXB4/METTL7B cascade mediates malignant phenotypes of hepatocellular carcinoma through TKT m6A modification.

Background: Hepatocellular carcinoma is a fatal malignancy that lacking specific therapies. Homeobox B4 (HOXB4) was negatively correlated with poor prognosis in cancers, but its role in hepatocellular carcinoma has not been elucidated.

Results: We confirmed that HOXB4 was downregulated in hepatocellular carcinoma tissues and lower HOXB4 expression associated with poor prognosis.

Nano-flower spherical NiFe LDH adsorbent for efficient removal of HS in blast furnace gas.

Removal of sulfur species from blast furnace gas is urgently needed due to the strict emission limits imposed on iron-steel industrial flue gas. Improving the sulfur capacity of HS is a crucial challenge to reduce the operation cost. NiFe layered double hydroxide (LDH) adsorbents were synthesized using the hydrothermal method to strengthen the adsorption of HS, achieving a high sulfur capacity of 133.

The importance of the Autostrain RV technique in the treatment of right ventricular myocardial alterations in patients with breast cancer receiving chemotherapy.

To research the value of Autostrain right ventricular (RV) technology in detecting and preventing right ventricular myocardial injury in patients undergoing breast cancer chemotherapy by providing an imaging basis for early identification. To examine the changes in various cardiac function parameters before and after chemotherapy, two-dimensional echocardiography was employed 48 h before chemotherapy, 48 h after the fourth cycle of chemotherapy, and 48 h after the eighth cycle of chemotherapy, respectively. The patients included those with breast cancer who underwent surgery and were primarily administered anthracycline-based chemotherapeutic drugs.

Pilot-scale testing on catalytic hydrolysis of carbonyl sulfur combined with absorption-oxidation of HS for blast furnace gas purification.

About 70% of the flue gas in the iron-steel industry has achieved multi-pollutant ultra-low emissions in China until 2023, and then the blast furnace gas purification has become the control step and bottleneck. Our research group has designed and constructed the world's first blast furnace gas desulfurization pilot plant with the scale of 2000 Nm/h in October 2021. The pilot plant is a two-step combined desulfurization device including catalytic hydrolysis of carbonyl sulfur (COS) and absorption-oxidation of HS, continuously running for 120 days.

Construction of bupivacaine-loaded gelatin-based hydrogel delivery system for sciatic nerve block in mice.

Peripheral nerve blockade (PNB) is a common treatment to relieve postoperative pain. However, local anesthetics alone have a short duration of action and severe side effects during postoperative analgesia. In order to overcome these limitations, the present study reported an injectable hydrogel with a drug slow-release profile for regional nerve blockade.

The Effects of Processing Parameters during the Wire Arc Additive Manufacturing of 308L Stainless Steel on the Formation of a Thin-Walled Structure.

Wire arc additive manufacturing (WAAM) excels in producing medium to large components with a high deposition rate. Process optimization is crucial for uniform, defect-free components. This research employs orthogonal experimental design and response surface methodology (RSM) to control TIG WAAM-ed 308L stainless steel components.

Hydrolysis of Carbonyl Sulfide in Blast Furnace Gas Using Alkali Metal-Modified γ-AlO Catalysts with High Sulfur Resistance.

A carbonyl sulfide (COS) hydrolysis catalyst can play an efficient role in blast furnace gas (BFG), but the life of the catalyst is greatly shortened due to the presence of O and HS in the atmosphere, so improving the sulfur resistance of the catalyst is the key to application. In this work, alkali metals Na and K modified γ-AlO catalysts to improve COS hydrolysis efficiency and sulfur resistance by adding an alkaline center. Compared with γ-AlO catalysts, the COS hydrolysis efficiency of the modified catalysts in the experiment was improved by 12% in the presence of HS and O.

TACC3 is an independent prognostic marker, and knockdown of TACC3 enhances the efficacy of CDK1 inhibitor RO3306 in liver cancer cells.

The drug resistance of single-target therapy has gradually become an intractable clinical problem. Combination therapy may be an effective treatment to overcome or postpone drug resistance in cancer. Herein, we discussed the synergistic effect of transforming acidic coiled-coil containing protein 3 (TACC3) suppression and cyclin-dependent kinase 1 (CDK1) in hepatocellular carcinoma (HCC).

The Way to Spend a Workday Matters in School Principals' Somatic and Psychological Discomfort.

Background: School principals usually have to sacrifice health and family obligations to obtain sufficient work time. This study investigates school principals' somatic and psychological discomfort related to their time allocation to diverse work contexts and life domains, so as to test the optimal allocation of time to each context and domain.

Methods: This study is based on survey data of 347 school principals, from the preexisting 2021 Survey of School Teachers' Living Conditions in Shanghai.

Effect of oval foramen restriction and premature contraction of the arterial catheter on right heart function of fetuses and infants.

Objective: The effect of fetal oval foramen restriction and premature contraction of the arterial catheter for the right heart function of fetuses and infants was studied by evaluating the right and left ventricular (RV/LV) ratios, the tricuspid annular plane systolic excursion (TAPSE) value, and the Tei index of right heart function parameters.

Methods: This study was approved by the Ethics Committee of First Affiliated Hospital of Hebei North University (K20190116). We collected 257 fetuses between March 2020 and December 2021.

Therapeutic Efficacy of a Staged Hybrid Technique vs. Coronary Artery Bypass Surgery Grafting in The Treatment of Multi-Vessel Coronary Artery Disease.

Objective: Hybrid coronary revascularization (HCR) integrates the advantages of coronary artery bypass surgery grafting (CABG) and percutaneous coronary intervention (PCI) and provides another effective treatment for multi-vessel coronary artery disease (CAD). This study aimed to investigate the short- and intermediate-term efficacies of a staged hybrid technique vs. CABG in treating older patients with multi-vessel CAD.

Isolation and oral immunogenicity assessment of porcine epidemic diarrhea virus NH-TA2020 strain: One of the predominant strains circulating in China from 2017 to 2021.

Porcine epidemic diarrhea (PED) caused by porcine epidemic diarrhea virus (PEDV) is one of the most devastating diseases in the global pig industry due to its high mortality rate in piglets. Maternal vaccines can effectively enhance the gut-mammary gland-secretory IgA axis to boost lactogenic immunity and passive protection of nursing piglets against PEDV challenge. From 2017 to 2021, we collected 882 diarrhea samples from 303 farms in China to investigate the epidemiology of PEDV.

microRNA-145-5p attenuates acute lung injury via targeting ETS2.

The protective effect of microRNA (miR)-145-5p in acute lung injury (ALI) has been discovered previously. Thus, in this study, we attempted to further investigate the mechanism of miR-145-5p in ALI through the downstream E26 transformation-specific proto-oncogene 2 (ETS2)/transforming growth factor β1 (TGF-β1)/Smad pathway. A lipopolysaccharide (LPS)-induced ALI rat model was established.

Working Conditions Influencing Junior School Principalship as a Satisfying Profession: A Cross-Country Comparative Study.

Although prior studies have extensively investigated the effect of working conditions upon professional satisfaction, the cross-national variance in the effect remains largely understudied due to technical or financial restrictions. The Teaching and Learning International Survey (TALIS) provides an opportunity to investigate the cross-country differences in the impact of working conditions upon principals' professional satisfaction. The current study attempts to investigate the overall and specific effects of principals' workplace environment satisfaction, rewards satisfaction, and workload stress on their professional satisfaction in 47 countries included in the TALIS 2018.

Exploring the impact of under-reported cases on the COVID-19 spatiotemporal distributions using healthcare workers infection data.

A timely understanding of the spatiotemporal pattern and development trend of COVID-19 is critical for timely prevention and control. However, the under-reporting of casesis widespread in fields associated with public health. It is also possible to draw biased inferences and formulate inappropriate prevention and control policies if the phenomenon of under-reporting is not taken into account.

Electrochemical Regioselective Cross-Dehydrogenative Coupling of Indoles with Xanthenes.

An electrochemical cross-dehydrogenative coupling of indoles with xanthenes has been established at room temperature. This coupling reaction could proceed in the absence of any catalyst or external oxidant, and generate the indole derivatives in moderate yields. Mechanistic experiments support that a radical pathway maybe involved in this reaction system.

ALKBH5 Is Lowly Expressed in Esophageal Squamous Cell Carcinoma and Inhibits the Malignant Proliferation and Invasion of Tumor Cells.

Background: Modification of N-methyladenosine (mA) and RNA mA regulatory factors is required in cancer advancement. The contribution of mA and its alteration in esophageal squamous cell carcinoma (ESCC) is still unclear.

Results: ALKBH5 was lowly expressed in ESCC tissues, which the total mA level was increased in ESCC tissue than the presentation in normal healthy tissue.

Responses of leaf carbon, nitrogen, and phosphorus stoichiometry of to water table drawdown in an alpine marsh on the Ruoergai Plateau, China.

Based on a field water table drawdown manipulation platform of Naleqiao marsh on the Rueorgai Plateau, we lifted soil block of 1 m×1 m by 20 cm for simulating water table decline, and analyzed the response of carbon, nitrogen, and phosphorus stoichiometry in the wetland species from June to September 2020. The results showed that there was no significant difference in leaf C content during the whole growing season, while N and P content gra-dually decreased along the growing season. After the drawdown of water table, the C content in leaves during the growing season was not consistent.

Study on the safety and effectiveness of drug-coated balloons in patients with acute myocardial infarction.

Background: Drug-coated balloon (DCB) is a new technology that has emerged in recent years and has been proven to be effective and safe in the treatment of in-stent restenosis. The purpose of this article is to observe the safety and effectiveness of drug-coated balloons in patients with acute myocardial infarction.

Method: We selected 80 patients admitted to the hospital for STEMI from January 2018 to December 2019.

Analysis of the value of N-terminal pro-B-type natriuretic peptide (NT-proBNP) and other parameters related to right heart function in detecting acute radiation-induced right heart injury.

Background: The aim of the present study was to investigate the value of parameters related to right heart function combined with N-terminal pro-B-type natriuretic peptide (NT-proBNP) in acute radiation-induced right heart injury.

Methods: Seventy patients who received chest radiotherapy (RT) in the RT department of our hospital between September 2015 and March 2019 were included in the study.

Results: Of the included 70 patients, 19, 32, 4, and 15 had thoracic esophageal cancer, central lung cancer, thymoma, and left breast cancer, respectively.

Building an Open Resources Repository for COVID-19 Research.

The COVID-19 outbreak is a global pandemic declared by the World Health Organization, with rapidly increasing cases in most countries. A wide range of research is urgently needed for understanding the COVID-19 pandemic, such as transmissibility, geographic spreading, risk factors for infections, and economic impacts. Reliable data archive and sharing are essential to jump-start innovative research to combat COVID-19.

Safety evaluation and ibuprofen removal via an Alternanthera philoxeroides-based biochar.

Pharmaceutical and personal care products (PPCPs) are a representative class of emerging contaminants. This study aimed to investigate the PPCP removal performance and application safety of a biochar fabricated using the invasive plant Alternanthera philoxeroides (APBC). According to scanning electron microscopy and pore size analyses, APBC exhibited a porous structure with a specific surface area of 857.