Spatial Clustering for Carolina Breast Cancer Study.

In the Carolina Breast Cancer Study (CBCS), clustering census tracts based on spatial location, demographic variables, and socioeconomic status is crucial for understanding how these factors influence health outcomes and cancer risk. This task, known as spatial clustering, involves identifying clusters of similar locations by considering both geographic and characteristic patterns. While standard clustering methods such as K-means, spectral clustering, and hierarchical clustering are well-studied, spatial clustering is less explored due to the inherent differences between spatial domains and their corresponding covariates.

Adeno-associated virus-mediated expression of activated factor V (FVa) for hemophilia phenotypic correction.

Adeno-associated virus (AAV) gene therapy has been successfully applied in hemophilia patients excluding patients with inhibitors. During the coagulation pathway, activated factor V (FVa) functions downstream as a cofactor of activated factor X (FXa) to amplify thrombin generation. We hypothesize that the expression of FVa via gene therapy can improve hemostasis of both factor IX and FVIII deficiencies, regardless of clotting factor inhibitor.

Customized blood-brain barrier shuttle peptide to increase AAV9 vector crossing the BBB and augment transduction in the brain.

Recombinant adeno-associated virus (rAAV) vectors have been widely used as favored delivery vehicles for the treatment of inherited diseases in clinical trials, including neurological diseases. However, the noninvasive systemic delivery of rAAV to the central nervous system is severely hampered by the blood-brain barrier (BBB). Several approaches have been exploited to enhance AAV vector brain transduction after systemic administration, including genetic modification of AAV capsids and physical methods.