Detection of Hg in environmental water conditions by using a reusable SERS-based microfluidic chip with a high specificity and sensitivity.

This work reported a surface-enhanced Raman spectroscopy (SERS)-based microfluidic chip that detects mercury ions (Hg) in water with high sensitivity and good reproducibility. Silver nanoparticles (AgNPs) are easily fabricated on a Si substrate using a thin, thermally treated Ag film. Cy3 functionalized single-stranded DNA (Cy3-ssDNA) serves as the probe, which is immobilized on the AgNPs (Cy3-ssDNA/AgNPs), generating a SERS-based sensing surface.

Microstructural white matter injury contributes to cognitive decline: Besides amyloid and tau.

Background: Cognitive decline and the progression to Alzheimer's disease (AD) are traditionally associated with amyloid-beta (Aβ) and tau pathologies. This study aims to evaluate the relationships between microstructural white matter injury, cognitive decline and AD core biomarkers.

Methods: We conducted a longitudinal study of 566 participants using peak width of skeletonized mean diffusivity (PSMD) to quantify microstructural white matter injury.

Sensitive Fluorescent Probe for Al, Cr and Fe: Application in Real Water Samples and Logic Gate.

Construction of single probes for simultaneous detection of common trivalent metal ions has attracted much attention due to higher efficiency in analysis and cost. A naphthalimide-based fluorescent probe K1 was synthesized for selective detection of Al, Cr and Fe ions. Fluorescence emission intensity at 534 nm of probe K1 in DMSO/HO (9:1, v/v) was significantly enhanced upon addition of Al, Cr and Fe ions while addition of other metal ions (Li, Na, K, Ag, Cu, Fe, Zn, Co, Ni, Mn, Sr, Hg, Ca, Mg, Ce, Bi and Au) did not bring about substantial change in fluorescence emission.

Size-dependent selectivity and quantification on detecting PS nanoplastics particles in a mixed solution with different diameters by using periodic Ag nanocavities SERS substrates with high sensitivity.

Nanoplastic particles (NPPs) have attracted lots of attention due to their toxicity. In this study, a Surface-enhanced Raman scattering (SERS)-based category on selectivity and quantification detecting the polystyrene (PS) NPPs has been presented. Firstly, the size-dependent SERS relationship between the diameter of Ag nanocavities (AgNCAs) and the diameter of the PS NPPs is studied.

A Novel Dataset and Detection Method for Unmanned Aerial Vehicles Using an Improved YOLOv9 Algorithm.

With the growing popularity of unmanned aerial vehicles (UAVs), their improper use is significantly disrupting society. Individuals and organizations have been continuously researching methods for detecting UAVs. However, most existing detection methods fail to account for the impact of similar flying objects, leading to weak anti-interference capabilities.

Spermine Synthase : A Potential Prognostic Marker for Lower-Grade Gliomas.

Objective: The objective of this study was to assess the relationship between spermine synthase (SMS) expression, tumor occurrence, and prognosis in lower-grade gliomas (LGGs).

Methods: A total of 523 LGG patients and 1152 normal brain tissues were included as controls. Mann-Whitney U test was performed to evaluate SMS expression in the LGG group.

Reactive Fluorescent and Colorimetric Probe for Highly Selective and Sensitive Detection of Hg in Real Water Samples.

Construction of efficient chemosensors for highly specific and sensitive detection of mercury ions remains a great challenge. In this work a highly selective and sensitive probe CY was designed and synthesized by using coumarin fluorophore as the matrix and thioacetal moiety as the reactive recognition site for Hg. By virtue of the thiophilicity of Hg, probe CL could be hydrolyzed to deprotect and the thioacetal was transformed to the acyl group after the addition of Hg, the blue-green fluorescence was quenched and meanwhile the solution changed from light green to yellow.

Multifunctional near-infrared fluorescent probe for sensing of lysine and Cu/Fe and relay detection of biothiols.

Lysine (Lys), Cu and Fe ions and biothiols are essential to a myriad of biological and pathological pathways, and their dysregulation is implicated in a variety of diseases. Development of fluorescent probes capable of detecting multiple analytes may be of great significance for early and accurate diagnosis of diseases and remains a huge challenge. In this context, a novel coumarin-dicyanoisophorone-based probe, engineered for the concurrent sensing of Lys, Cu, Fe and biothiols was developed.

Characterizing the relationship between MRI radiomics and AHR expression and deriving a predictive model for prognostic assessment in glioblastoma.

Purpose: Aryl hydrocarbon receptor (AHR), a crucial molecular marker associated with glioma, is a potential therapeutic target. We aimed to establish a non-invasive predictive model for AHR through radiomics.

Methods: Contrast-enhanced T1-weighted (T1W) MRI and the corresponding and clinical variables of glioblastoma patients from The Cancer Genome Atlas (TCGA) and The Cancer Imaging Archive (TCIA) were obtained for analysis.

Dysregulated Ribosome Biogenesis Is a Targetable Vulnerability in Triple-Negative Breast Cancer: MRPS27 as a Key Mediator of the Stemness-inhibitory Effect of Lovastatin.

Triple-negative breast cancer (TNBC) is the most aggressive subtype of breast cancer with limited effective therapeutic options readily available. We have previously demonstrated that lovastatin, an FDA-approved lipid-lowering drug, selectively inhibits the stemness properties of TNBC. However, the intracellular targets of lovastatin in TNBC remain largely unknown.

MTC-CSNet: Marrying Transformer and Convolution for Image Compressed Sensing.

Image compressed sensing (ICS) has been extensively applied in various imaging domains due to its capability to sample and reconstruct images at subNyquist sampling rates. The current predominant approaches in ICS, specifically pure convolutional networks (ConvNets)-based ICS methods, have demonstrated their effectiveness in capturing local features for image recovery. Simultaneously, the Transformer architecture has gained significant attention due to its capability to model global correlations among image features.

CKS1B as a potential target for prognostic assessment and intervention in pancreatic cancer and its role in abnormal proliferation and cellular phenotype through mediation of cell cycle signaling pathways.

Objectives: To investigate the role of cell cycle protein-dependent kinase regulatory subunit 1B (CKS1B) in driving the aggressive and rapid proliferation observed in pancreatic cancer.

Methods: A comprehensive analysis was carried out using raw mRNA information and data from 2 databases: the cancer genome atlas and gene expression omnibus. The differential expression of CKS1B at the mRNA and tissue levels in cancer and adjacent paracancerous tissues were assessed.

Associations between adiposity and white matter hyperintensities: Cross-sectional and longitudinal analyses of 34,653 participants.

Objectives: White matter hyperintensities (WMH) increase the risk of stroke and cognitive impairment. This study aims to determine the cross-sectional and longitudinal associations between adiposity and WMH.

Methods: Participants were enrolled from the UK Biobank cohort.

Near-infrared fluorescent probe with large Stokes shift for specific detection of lysine.

A new near-infrared (NIR) fluorescent probe CL based on coumarin- dicyanoisophorone was synthesized. Addition of Lys to probe CL solution in DMF/HO (9:1, v/v) medium resulted in noticeable enhancement in the intensity of the fluorescence emission at 702 nm, accompanying distinct color change from yellow to pink. While addition of other amino acids and biothiols (Gly, Hcy, GSH, Glu, Val, Tyr, Arg, Trp, Lys, His, Leu, Phe, Asp and Met) did not bring about substantial changes in both fluorescence emission and color.

Survival benefit of local consolidative therapy for patients with single-organ metastatic pancreatic cancer: a propensity score-matched cross-sectional study based on 17 registries.

Background: The continuous exploration of oligometastatic disease has led to the remarkable achievements of local consolidative therapy (LCT) and favorable outcomes for this disease. Thus, this study investigated the potential benefits of LCT in patients with single-organ metastatic pancreatic ductal adenocarcinoma (PDAC).

Methods: Patients with single-organ metastatic PDAC diagnosed between 2010 - 2019 were identified from the Surveillance, Epidemiology, and End Results (SEER) database.

Selective and Sensitive Detection of Hg and Ag by a Fluorescent and Colorimetric Probe with Large Stokes Shift.

Development of fluorescent sensors with large Stokes shift for selective detection of heavy metals is of great importance. A novel fluorescent probe with extremely large Stokes shift (212 nm) was synthesized for selective and simultaneous detection of Hg and Ag ions. The deep yellow probe turned colorless or pale yellow after addition of Hg or Ag.

Multipredictor risk models for predicting individual risk of Alzheimer's disease.

Background: Early prevention of Alzheimer's disease (AD) is a feasible way to delay AD onset and progression. Information on AD prediction at the individual patient level will be useful in AD prevention. In this study, we aim to develop risk models for predicting AD onset at individual level using optimal set of predictors from multiple features.

Associations of circulating metabolites with cerebral white matter hyperintensities.

White matter hyperintensities (WMH) are the most compelling risk factors of stroke, dementia, and early mortality. We aimed to investigate the associations between WMH and circulating metabolites. We studied up to 8190 individuals from the UK Biobank, who have both measurements of 249 plasma metabolites and WMH volume.

[Retracted] FAM172A induces S phase arrest of HepG2 cells via Notch 3.

Following the publication of the above article, a concerned reader drew to the Editor's attention that the western blots featured in Figs. 1G, 2B, 3B and 4E contained groupings of bands that were markedly similar in appearance, both within the same gel slices and comparing across different gel slices between the figures in the case of Figs. 3 and 4.

[Retracted] SIRT3 regulates cell proliferation and apoptosis related to energy metabolism in non‑small cell lung cancer cells through deacetylation of NMNAT2.

Following the publication of this paper, it was drawn to the Editor's attention by a concerned reader that the control β‑actin western blots shown in Fig. 4C were strikingly similar to data appearing in different form in Fig. 9B in a previously published paper featuring one author in common; moreover, the immunoblotting experiments shown in Figs.

Attenuation of renal injury by depleting cDC1 and by repurposing Flt3 inhibitor in anti-GBM disease.

Previous studies found cDC1s to be protective in early stage anti-GBM disease through Tregs, but pathogenic in late stage Adriamycin nephropathy through CD8 T cells. Flt3 ligand is a growth factor essential for cDC1 development and Flt3 inhibitors are currently used for cancer treatment. We conducted this study to clarify the role and mechanisms of effects of cDC1s at different time points in anti-GBM disease.