Construction of a prognostic 6-gene signature for breast cancer based on multi-omics and single-cell data.

Background: Breast cancer (BC) is one of the females' most common malignant tumors there are large individual differences in its prognosis. We intended to uncover novel useful genetic biomarkers and a risk signature for BC to aid determining clinical strategies.

Methods: A combined significance ( ) was calculated for each gene by Fisher's method based on the RNA-seq, CNV, and DNA methylation data from TCGA-BRCA.

Synthetic MRI in breast cancer: differentiating benign from malignant lesions and predicting immunohistochemical expression status.

To evaluate and compare the performance of synthetic magnetic resonance imaging (SyMRI) in classifying benign and malignant breast lesions and predicting the expression status of immunohistochemistry (IHC) markers. We retrospectively analysed 121 patients with breast lesions who underwent dynamic contrast-enhanced magnetic resonance imaging (DCE-MRI) and SyMRI before surgery in our hospital. DCE-MRI was used to assess the lesions, and then regions of interest (ROIs) were outlined on SyMRI (before and after enhancement), and apparent diffusion coefficient (ADC) maps to obtain quantitative values.

Properties of Spherically Symmetric Black Holes in the Generalized Brans-Dicke Modified Gravitational Theory.

The many problems faced by the theory of general relativity (GR) have always motivated us to explore the modified theory of GR. Considering the importance of studying the black hole (BH) entropy and its correction in gravity physics, we study the correction of thermodynamic entropy for a kind of spherically symmetric black hole under the generalized Brans-Dicke (GBD) theory of modified gravity. We derive and calculate the entropy and heat capacity.

MYCL promotes the progression of triple‑negative breast cancer by activating the JAK/STAT3 pathway.

The present study aimed to investigate the underlying regulatory mechanism of MYCL proto‑oncogene (MYCL) in triple‑negative breast cancer (TNBC) progression. experiments were performed to confirm the functional roles of MYCL in TNBC, and its effects on the JAK/STAT3 pathway through flow cytometric analysis, colony formation, wound healing and Transwell assays. In addition, the GSE45498 dataset demonstrated that MYCL was upregulated in TNBC and that it was significantly related to poor survival of patients with TNBC.

A Novel Necroptosis-Related miRNA Signature for Predicting the Prognosis of Breast Cancer Metastasis.

Objective: Necroptosis was recently identified as a form of programmed cell death that plays an essential role in breast cancer metastasis. MicroRNAs (miRNAs) have long been recognized to affect cell death and tumor growth. In this study, we aimed to screen for necroptosis-associated miRNAs that predict breast cancer metastasis.

The Pharmacological Mechanisms of Xiaochaihutang in Treating Breast Cancer Based on Network Pharmacology.

Background: As a classic prescription in Chinese medicine treatment, Xiaochaihutang (XCHT) can improve the clinical effect and reduce serum tumor markers in patients with breast cancer (BC). However, there has not been any study to confirm the mechanism. We used bioinformatics analysis and network pharmacology to find the potential targets.

Long non-coding RNA SNHG3 promotes breast cancer cell proliferation and metastasis by binding to microRNA-154-3p and activating the notch signaling pathway.

Background: Breast cancer (BC) is a malignant tumor that occurs in the epithelial tissue of the breast gland. Long non-coding RNA (lncRNA) small nucleolar RNA host gene 3 (SNHG3) has been found to promote BC cell proliferation and invasion by regulating the microRNA (miR)-101/zinc-finger enhancer binding axis in BC. Herein, the objective of the present study is to evaluate the effect of lncRNA SNHG3 on BC cell proliferation and metastasis with the Notch signaling pathway.

Locally Trapping the C-C Chemokine Receptor Type 7 by Gene Delivery Nanoparticle Inhibits Lymphatic Metastasis Prior to Tumor Resection.

Triple negative breast cancer (TNBC) is the most aggressive breast cancer subtype. Currently, no targeted treatment is available for TNBC, and the most common clinical therapy is tumor resection, which often promotes metastasis risks. Strong evidence suggests that the lymphatic metastasis is mediated by the C-C chemokine receptor type 7 (CCR7)/C-C motif chemokine ligand 21 crosstalk between tumor cells and the lymphatic system.

[Study on the soil salinization monitoring based on measured hyperspectral and HSI data].

The present paper selects the Kuqa Oasis as the study area, studies spectrum characteristics of soil salinity, and establishes soil spectrum library. Through transforming and analyzing varying degrees of soil salinization reflectance spectra data in the typical study area, and selecting the most sensitive spectral bands in response to salinization, we established the measured hyperspectral soil salinity monitoring model, and by correcting the soil salinity monitoring model established by HIS image through scale effect conversion improved the model accuracy under the conditions of a regional-scale monitoring of soil salinization. The results show that both measured hyperspectral soil salinity monitoring model and HSI image soil salinity inversion model have good accuracy, model determination coefficient (R2) is higher than 0.

Correlation of ADC value with pathologic indexes in colorectal tumor homografts in Balb/c mouse.

Objective: Noninvasive diffusion-weighted magnetic resonance imaging (DWI) is a well-studied MR imaging technique for quantifying water diffusion especially in tumor area. The correlation between apparent diffusion coefficient (ADC) value and apoptosis or proliferation is not clear by now. This study aimed to investigate whether DWI-ADC value could be used as an imaging marker related with pathologic indexes of tumors.

[Monitoring of soil salinization in Northern Tarim Basin, Xinjiang of China in dry and wet seasons based on remote sensing].

Soil salinization is one of the most important eco-environment problems in arid area, which can not only induce land degradation, inhibit vegetation growth, but also impede regional agricultural production. To accurately and quickly obtain the information of regional saline soils by using remote sensing data is critical to monitor soil salinization and prevent its further development. Taking the Weigan-Kuqa River Delta Oasis in the northern Tarim River Basin of Xinjiang as test object, and based on the remote sensing data from Landsat-TM images of April 15, 2011 and September 22, 2011, in combining with the measured data from field survey, this paper extracted the characteristic variables modified normalized difference water index (MNDWI), normalized difference vegetation index (NDVI), and the third principal component from K-L transformation (K-L-3).