Ellagic acid-enhanced biocompatibility and bioactivity in multilayer core-shell gold nanoparticles for ameliorating myocardial infarction injury.

Background: Myocardial infarction (MI) is the main contributor to most cardiovascular diseases (CVDs), and the available post-treatment clinical therapeutic options are limited. The development of nanoscale drug delivery systems carrying natural small molecules provides biotherapies that could potentially offer new treatments for reactive oxygen species (ROS)-induced damage in MI. Considering the stability and reduced toxicity of gold-phenolic core-shell nanoparticles, this study aims to develop ellagic acid-functionalized gold nanoparticles (EA-AuNPs) to overcome these limitations.

Structural characterization and mechanisms of macrophage immunomodulatory activity of a novel polysaccharide with a galactose backbone from the processed Polygonati Rhizoma.

A purified polysaccharide with a galactose backbone (SPR-1, Mw 3,622 Da) was isolated from processed Polygonati Rhizoma with black beans (PRWB) and characterized its chemical properties. The backbone of SPR-1 consisted of [(4)-β-D-Gal-(1] → 4,6)-β-D-Gal-(1 → 4)-α-D-GalA-(1 → 4)-α-D-GalA-(1 → 4)-α-D-Glc-(1 → 4,6)-α-D-Glc-(1 → 4)-α/β-D-Glc, with a branch chain of R: β-D-Gal-(1 → 3)-β-D-Gal-(1→ connected to the →4,6)-β-D-Gal-(1→ via O-6, and a branch chain of R: α-D-Glc-(1 → 6)-α-D-Glc-(1→ connected to the →4,6)-α-D-Glc-(1→ via O-6. Immunomodulatory assays showed that the SPR-1 significantly activated macrophages, and increased secretion of NO and cytokines (i.

Comparative analysis of phytochemical profile and antioxidant and anti-inflammatory activity of four Gentiana species from the Qinghai-Tibet Plateau.

Ethnopharmacological Relevance: Gentiana species, known as the traditional Tibetan medicine "Bangjian," have been integral to clinical practice for millennia. Despite their longstanding use, our understanding of the variation in chemical constituents and bioactive effects among different species is limited.

Aim Of The Study: In the present study, we aimed to assess the differences in chemical profiles and bioactivities among four Gentiana species (G.

Chemical profiling and rapid discrimination of and by UPLC-Q-Exactive-MS/MS and HPLC.

Objective: To rapidly identify the two morphologies and chemical properties of similar herbal medicines, and as the basis for chemical constituent analysis.

Methods: UPLC-Q-Exactive-MS/MS was utilized for profiling and identification of the constituents in and . Chemical pattern recognition (CPR) was further used to compare and distinguish the two herbs and to identify their potential characteristic markers.

[Chemical constituents and anti-liver fibrosis mechanism of Meconopsis quintuplinervia based on UPLC-Q-Exactive-MS/MS and network pharmacology].

In this study, UPLC-Q-Exactive-MS/MS was used to rapidly analyze the chemical constituents of Meconopsis quintupli-nervia, and the anti-liver fibrosis mechanism of M. quintuplinervia was preliminarily analyzed by network pharmacology, molecular docking, and cell experiments. The chemical constituents of M.