Structure-based virtual screening identifies small-molecule inhibitors of O-fucosyltransferase SPINDLY in Arabidopsis.

Protein O-glycosylation is a nutrient signaling mechanism that plays an essential role in maintaining cellular homeostasis across different species. In plants, SPINDLY (SPY) and SECRET AGENT (SEC) posttranslationally modify hundreds of intracellular proteins with O-fucose and O-linked N-acetylglucosamine, respectively. SPY and SEC play overlapping roles in cellular regulation, and loss of both SPY and SEC causes embryo lethality in Arabidopsis (Arabidopsis thaliana).

Structure-based virtual screening identifies small molecule inhibitors of O-fucosyltransferase SPINDLY.

Protein O-glycosylation is a nutrient-signaling mechanism that plays essential roles in maintaining cellular homeostasis across different species. In plants, SPINDLY (SPY) and SECRET AGENT (SEC) catalyze posttranslational modifications of hundreds of intracellular proteins by O-fucose and O-linked N-acetylglucosamine, respectively. SPY and SEC play overlapping roles in cellular regulation and loss of both SPY and SEC causes embryo lethality in Arabidopsis.

Microtopography mediates the climate-growth relationship and growth resilience to drought of plantation in the hilly site.

Understanding the factors affecting the growth of plantation forests can reduce the loss of economic and ecological values caused by plantation forest subhealth. Plantation forests are widely distributed in hilly areas with microtopographic features. Microtopography influences climatic factors associated with plant growth, during not only general time but also extreme events like droughts.

Cytokinin regulates apical hook development via the coordinated actions of EIN3/EIL1 and PIF transcription factors in Arabidopsis.

The apical hook is indispensable for protecting the delicate shoot apical meristem while dicot seedlings emerge from soil after germination in darkness. The development of the apical hook is co-ordinately regulated by multiple phytohormones and environmental factors. Yet, a holistic understanding of the spatial-temporal interactions between different phytohormones and environmental factors remains to be achieved.

Athermal repair of nanoscale defects in optical materials using a femtosecond laser.

Ion implantation is widely used to fabricate advanced optical and optoelectronic materials and devices. However, nanoscale defects generated during the ion implantation process severely affect the quality and properties of the material and device. Here, combining computational simulations and experiments, we investigate the mechanism for defect repair in fused silica after Cu ion implantation using femtosecond laser irradiation with an energy fluence much lower than the ablation threshold.

[Improvement of cardiac function by recombinant adenovirus Ad-hBNP in rats with chronic heart failure].

Objective: To evaluate the therapeutic effect of hBNP on rats with chronic heart failure (CHF).

Methods: Thirty CHF rats defined by echocardiography at 12 weeks post abdominal aortic constriction were randomly divided into Ad-hBNP group (2.5 × 10(10) VP/ml NS Ad-hBNP 1 ml/week × 4, n = 14), Ad-Track group (n = 8), placebo group (NS, n = 8), 10 sham-operated rats served as control group.

Anisotropic in-plane spin splitting in an asymmetric (001) GaAs/AlGaAs quantum well.

The in-plane spin splitting of conduction-band electron has been investigated in an asymmetric (001) GaAs/AlxGa1-xAs quantum well by time-resolved Kerr rotation technique under a transverse magnetic field. The distinctive anisotropy of the spin splitting was observed while the temperature is below approximately 200 K. This anisotropy emerges from the combined effect of Dresselhaus spin-orbit coupling plus asymmetric potential gradients.

Beam conditions for radiation generated by an electromagnetic J0-correlated Schell-model source.

Based on the 2x2 (electric field) cross-spectral density matrix, a model for an electromagnetic J0-correlated Schell-model beam is given that is a generalization of the scalar J0-correlated Schell-model beam. The conditions that the matrix for the source to generate an electromagnetic J0-correlated Schell-model beam are obtained. The condition for the source to generate a scalar J0-correlated Schell-model beam can be considered as a special case.

Stable pulse-compressed acousto-optic Q-switched fiber laser.

A novel acousto-optic switch operation by a simple laser-diode pumped acousto-optic, Q-switched, ytterbium-doped, double-clad fiber laser is reported. Stable compressed Q-switched sub-40 ns pulses with a beam quality factor (M(2)=2) are achieved at the repetition rate of 1-50 kHz. Q-switched pulses of ~20 microJ pulse energy and 35 ns pulse width are obtained at the repetition rate of 50 kHz.

Compression of pulse duration in a laser-diode, end-pumped, double Q-switched laser.

By considering the Guassian transversal distribution of intracavity photon density and the longitudinal distribution of photon density along the cavity axis as well as the influence of the turn-off time of the acousto-optic Q switch, we introduce the coupled rate equations of a laser-diode, end-pumped, double Q-switched laser with an acousto-optic modulator and GaAs saturable absorber. In addition the thermal effect of the gain medium is taken into account. These coupled rate equations are solved numerically, and the dependence of pulse width on incident pump power at different pulse repetition rates is obtained for the generated output pulses.