Efficacy and Safety of Butylphthalide in Patients With Acute Ischemic Stroke: A Randomized Clinical Trial.

Importance: DL-3-n-butylphthalide (NBP) is a drug for treating acute ischemic stroke and may play a neuroprotective role by acting on multiple active targets. The efficacy of NBP in patients with acute ischemic stroke receiving reperfusion therapy remains unknown.

Objective: To assess the efficacy and safety of NBP in patients with acute ischemic stroke receiving reperfusion therapy of intravenous thrombolysis and/or endovascular treatment.

Rice Ear Counting Based on Image Segmentation and Establishment of a Dataset.

The real-time detection and counting of rice ears in fields is one of the most important methods for estimating rice yield. The traditional manual counting method has many disadvantages: it is time-consuming, inefficient and subjective. Therefore, the use of computer vision technology can improve the accuracy and efficiency of rice ear counting in the field.

Pig-Posture Recognition Based on Computer Vision: Dataset and Exploration.

Posture changes in pigs during growth are often precursors of disease. Monitoring pigs' behavioral activities can allow us to detect pathological changes in pigs earlier and identify the factors threatening the health of pigs in advance. Pigs tend to be farmed on a large scale, and manual observation by keepers is time consuming and laborious.

Kanglaite reverses multidrug resistance of HCC by inducing apoptosis and cell cycle arrest via PI3K/AKT pathway.

Background: Multidrug resistance (MDR) frequently contributes to the failure of chemotherapeutic treatments in patients diagnosed with hepatocellular carcinoma (HCC). Revealing the molecular mechanism of MDR is indispensable for the development of effective chemotherapeutic drugs.

Purpose: Due to the low-toxicity modulators to inhibit MDR, we considered that Kanglaite (KLT) is a potential agent for reversing MDR in HCC.

MiR-34a Inhibits Breast Cancer Proliferation and Progression by Targeting Wnt1 in Wnt/β-Catenin Signaling Pathway.

Background: As microRNA-34a (miR-34a) has been suggested to be associated with breast cancer (BC), this study was proposed to explore the underlying mechanism of miR-34a in suppressing BC progression.

Methods: A total of 123 pairs of tumor tissues and matched nontumor tissues were obtained from patients. Reverse transcription polymerase chain reaction and in situ hybridization were used to detect the differences in miR-34a expression in tissues and cells.

Triptolide induces apoptosis of breast cancer cells via a mechanism associated with the Wnt/β-catenin signaling pathway.

Triptolide is a diterpene triepoxide compound extracted from the medicinal plant, Hook F. The aim of the present study was to determine whether triptolide inhibits the proliferation of breast cancer cells and to further investigate the associated molecular mechanisms. The effects of triptolide on the cell viability of three breast cancer cell lines, specifically, highly metastatic MDA-MB-231, human epidermal growth factor receptor 2-positive BT-474 and estrogen receptor-positive MCF7 cells, were measured using 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide and apoptosis assays.

Matrine effectively inhibits the proliferation of breast cancer cells through a mechanism related to the NF-κB signaling pathway.

Matrine is an alkaloid isolated from . The present study aimed to determine whether matrine effectively inhibits the proliferation of breast cancer cells, and the underlying mechanism(s) of its antitumor function. The effects of matrine on the cell viability of ER-positive MCF7 cells, HER2-positive BT-474 cells and highly metastatic MDA-MB-231 cells were measured using MTT and apoptosis assays.

Surface enhanced fluorescence of physically polished nanostructured metal surface: the effect of the native oxide layer.

The fluorescence emission of Rhodamine 6G molecules at the physically polished nanostructured copper surface with varying thickness of the native oxide layer was investigated. The quenching effect was observed when the dye molecule was directly adsorbed onto the substrate surface without the formative oxide layer. However, the fluorescence was enhanced obviously when the native oxide layer was formed at the substrate surface.