Ratiometric fluorescent sensor with large pseudo-Stokes shifts for precise sensing and imaging of pH without interferential background fluorescence.

Endowing fluorescent pH sensors with large Stokes shifts promises to resolve interferential background fluorescence in practice, and yet few such method has been reported, owing to lack of luminescent materials with large Stokes shifts used in fluorescent sensors. Herein, we elaborately designed NaGdF:Ce@NaGdF:Nd@NaYF:Eu core-double shells (CDS) lanthanide-doped fluoride nanoparticles (LFNPs), employing Gd-mediated energy migration and interfacial energy transfer to realize intense red and NIR emissions under 254 nm irradiation, and pseudo-Stokes shifts of which reached up to striking 361 nm and 610 nm, respectively. The CDS LFNPs collaborated with absorption-based pH indicator bromocresol green to from a novel fluorescent sensor film, and employing low-cost dual chip RGB-NIR camera to precisely record luminescence signals.

Durability of immune response after SARS-CoV-2 vaccination in patients with chronic liver disease.

Aim: The present study aimed to evaluate the durability of immune response after basic and booster immunization with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) vaccines in patients with chronic liver disease (CLD).

Methods: Patients with CLD and complete basic or booster immunization with SARS-CoV-2 vaccines were included in this study. Based on the vaccination situation, they were divided into the basic immunity group (Basic) and the booster immunity group (Booster), which were then subdivided into four groups according to the time interval from completion of basic immunization or booster immunization to serological specimen collection.

Nontoxic Tb-induced hyaluronic nano-poached egg aggregates for colorimetric and luminescent detection of Fe ions.

This study demonstrates that a luminescent Tb complex with green emission can be complexed with hyaluronic (hya) to form nanoparticles. The structure of complexation is composed of a Tb(acac)phen core with a hya surface, similar to those of the nano-poached eggs. What makes the structure unique is that Tb(acac)phen and hya are connected by chemical bonds.

Efficacy and safety of anticoagulants in liver cirrhosis patients with portal vein thrombosis: A meta-analysis.

Objective: To investigate the efficacy and safety of anticoagulants in liver cirrhosis patients with portal vein thrombosis (PVT).

Methods: PubMed, BioMed Central, Cochrane Library and Web of Science were retrieved to identify relevant literature. Forest plots were applied to display the results of the meta-analysis.

Diagnosis and Treatment of Cirrhosis with Duodenal Variceal Bleeding: a Case Report.

Background: Cases of duodenal variceal hemorrhage after cirrhosis are rare, but patients have a higher mortality rate. There is currently no clinical guideline to address how such patients should choose preferred treatment.

Methods: We retrospectively evaluated the clinical information of a 65-year-old male admitted to the Gastroenterology Department with gastrointestinal bleeding.

Retracted Article: MicroRNA-1271 modulates hepatitis B virus replication, cell proliferation and apoptosis in hepatitis B virus-related hepatocellular carcinoma by targeting SIRT1.

Chronic hepatitis B virus (HBV) infection is a leading cause of hepatocellular carcinoma (HCC). Certain studies have revealed that microRNAs play crucial roles in HBV-related HCC. The aim of this study was to investigate the effects of microRNA-1271 (miR-1271) on HBV replication, cell proliferation and apoptosis in HBV-related HCC.

Research on minimum detectable activity (MDA) of underwater gamma spectrometer for radioactivity measurement in the marine environment.

To improve the capability of underwater gamma spectrometer to quantify radiation levels slightly above the background radiation in the seawater, the minimum detection activity (MDA) and factors including the background count, detection efficiency and acquisition time were studied using Monte Carlo simulation and field experiments. The simulation results show that the crystal type selected in the spectrometer and its volume, enclosure materials of the spectrometer and its thickness all affect the marine detection efficiency in in-situ measurement, and thus determine MDA of the underwater gamma spectrometer. The acquisition time and the placement depth of the spectrometer in the seawater also affect the MDA in the in-situ measurement.

Complete cure of a patient with HBV-associated hepatocellular carcinoma with lung metastasis using interferon and survival up to 108 months: A case report and literature review.

Hepatocellular carcinoma (HCC) has a poor prognosis due to its asymptomatic onset and susceptibility to metastasis. The survival of patients with advanced HCC is 6-12 months. As a first-line medicine for the control of hepatitis B virus, interferon (IFN) is also capable of inhibiting tumor growth and modulating immunity.

Different scoring systems to predict 6-week mortality in cirrhosis patients with acute variceal bleeding: a retrospective analysis of 202 patients.

Objective: Determine the optimal scoring system for evaluation of 6-week bleeding-related mortality in liver cirrhosis patients with acute variceal bleeding (AVB). Prediction effects of six scoring systems, AIMS65 score, Glasgow-Blatchford (GBS) score, full Rockall (FRS) score, the model for end-stage liver disease (MELD), the MELD-Na model and the Child-Turcotte-Pugh (CTP) score were analyzed in this study.

Methods: A total of 202 liver cirrhosis patients with AVB were enrolled between 1 January 2014, and 31 December 2014.

Propranolol suppresses the proliferation and induces the apoptosis of liver cancer cells.

An increasing amount of evidence indicates that the inhibition of β adrenergic signaling can result in the inhibition of tumor growth. However, the role of propranolol in liver cancer and the underlying mechanism remain to be elucidated. The present study aimed to investigate the role of propranolol in liver cancer cell lines and provide evidence for further clinical study.

Native chemical ligation combined with spirocyclization of benzopyrylium dyes for the ratiometric and selective fluorescence detection of cysteine and homocysteine.

Spirocyclization of xanthene dyes has become a powerful technique for developing fluorescent probes. Herein, we extend this unique fluorescence switching mechanism to a near-infrared (NIR) dye, 2-(7-diethylamino-2-oxo-2H-1-benzopyran-3-yl)-4-(2-carboxyphenyl)-7-diethylamino-1-benzopyrylium (CB), and construct a ratiometric fluorescent probe 1 for cysteine (Cys)/homocysteine (Hcy). The ratiometric sensing of probe 1 toward Cys/Hcy is realized by utilizing a tandem native chemical ligation/spirocyclization reaction to interrupt the large π-conjugated system of CB fluorophore, thereby affording remarkable blue shifts in the spectra of sensing system (from 669 to 423 nm in absorption spectra and from 694 to 474 nm in emission spectra).