Publications by authors named "Honglong Lu"
Article Synopsis
- * Researchers conducted an in-depth study using various public databases to examine how LY6H is expressed across 33 different human tumors and investigated its implications for diagnosis, prognosis, and immune response.
- * Findings indicated that LY6H is significantly overexpressed in many cancer types, suggesting its potential as a diagnostic marker and its involvement in immune cell regulation, with varying effects on prognosis depending on the type of cancer.
Tenacissimoside A (1) and 11alpha-O-benzoyl-12beta- O-acetyltenacigenin B (2), two derivatives of tenacigenin B (3) from the plant Marsdenia tenacissima, reversed multidrug resistance in P-glycoprotein (Pgp)-overexpressing multidrug-resistant cancer cells. The sensitivity of HepG2/Dox cells to the antitumor drugs doxorubicin, vinblastine, puromycin, and paclitexel was increased by 18-, 10-, 11-, and 6-fold by 20 microg/mL (or 25 microM) of 1 and 16-, 53-, 16-, and 326-fold by 20 microg/mL (or 39 microM) of 2, respectively. A preliminary mechanistic study has suggested that 1 might modulate Pgp-mediated multidrug resistance through directly interacting with the Pgp substrate site.
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