Evaluation of a half-digital technique for fabricating customized post-cores: A pilot study.

Objectives: The current half-digital post-core fabrication technique can replace the conventional methods; however, it does not consider the impact occlusion has on the digital design. This study proposed a half-digital workflow that integrated intracanal impression with dentition scanning, and evaluated the accuracy of the post-cores fabricated by it.

Methods: Standard models with three extracted teeth (a central incisor, a premolar, and a molar) were prepared.

Mechanical properties of bulk-fill resin composites with single increment up to 4 mm: A novel mechanical strength test.

Purpose: To evaluate the mechanical properties of two brands of bulk-fill resin composites placed in a single increment up to 4 mm thickness via a novel mechanical strength test and provide related explanations.

Methods: Light transmission (LT), translucency parameter (TP), color difference (ΔE), Vickers hardness (HV) of two bulk-fill resin composites (Filtek Bulk Fill Posterior, Tetric N-Ceram Bulk Fill) and two conventional resin composites (Z100, Spectrum TPH) were evaluated. A novel flexural strength (FS) test method was applied for bulk-fill resin composite to determine the FS value of the bottom composites at depths of 1, 2, 3, and 4 mm after 24 hours of aging treatment (3 months water storage and 15,000 thermal cycles).

NOTCH4 Single-Nucleotide Polymorphism Is Associated with Brain Arteriovenous Malformation in a Chinese Han Population.

Introduction: Brain arteriovenous malformations (BAVMs) are high-flow intracranial vascular malformations characterized by the direct connection of arteries to veins without an intervening capillary bed. They are one of the main causes of intracranial hemorrhage and epilepsy, although morbidity is low. Angiogenesis, heredity, inflammation, and arteriovenous malformation syndromes play important roles in BAVM formation.

In vitro comparison of bonding to zirconia- or glass- based ceramics between flowable resin composites and composite resin cements.

Purpose: To evaluate and compare the bonding of flowable resin composites and light-cured resin cements to dental ceramics.

Methods: Grit-blasted zirconia plates were primed with MDP-containing adhesive. Lithium disilicate glasses plates were etched with HF and primed with silane.

Identification and Potential Mechanisms of a 7-MicroRNA Signature That Predicts Prognosis in Patients with Lower-Grade Glioma.

Background: Lower-grade glioma is an intracranial cancer that may develop into glioblastoma with high mortality. The main objective of our study is to develop microRNA for LGG patients which will provide novel prognostic biomarkers along with therapeutic targets.

Methods: Clinicopathological data of LGG patients and their RNA expression profile were downloaded through The Cancer Genome Atlas Relevant expression profiles of RNA, and clinicopathological data of the LGG patients had been extracted from the database of "The Cancer Genome Atlas.

Identification of an N6-methyladenosine (m6A)-related signature associated with clinical prognosis, immune response, and chemotherapy in primary glioblastomas.

Background: N6-methyladenosine (m6A) RNA methylation regulators play crucial role in tumorigenicity and progression. However, their biological significance in primary glioblastomas (GBM) has not been fully elucidated.

Methods: In the present study, we evaluated the 22 m6A RNA regulators using the integrated data of primary GBM samples from The Cancer Genome Atlas and Chinese Glioma Genome Atlas databases.

Effects of Tribochemical Silica Coating and Alumina-Particle Air Abrasion on 3Y-TZP and 5Y-TZP: Evaluation of Surface Hardness, Roughness, Bonding, and Phase Transformation.

Purpose: To determine and compare the effects of tribochemical silica coating and alumina-particle air abrasion on 3 mol% and 5 mol% yttria-stabilized tetragonal zirconia polycrystals (Y-TZP).

Materials And Methods: Two different 3Y-TZP samples (Lava Plus, 3M Oral Care; Ceramill Zolid, Amann Girrbach) and one 5Y-TZP sample (Katana Zirconia UTML, Kuraray Noritake) were prepared and treated with alumina-particle air abrasion and a 10-methacryloyloxydecyl dihydrogen phosphate (10-MDP)-containing self-adhesive composite cement or with tribochemical silica coating followed by silanization (n = 30). Resin columns were cemented onto the treated ceramic surfaces to form specimens.

Shear bond strength of zirconia to resin: The effects of specimen preparation and loading procedure.

Purpose: Shear bond strength (SBS) test is the most commonly used method for evaluating resin bond strength of zirconia, but SBS results vary among different studies even when evaluating the same bonding strategy. The purpose of this study was to promote standardization of the SBS test in evaluating zirconia ceramic bonding and to investigate factors that may affect the SBS value of a zirconia/resin cement/composite resin bonding specimen.

Materials And Methods: The zirconia/resin cement/composite resin bonding specimens were used to simulate loading with a shear force by the three-dimensional finite element (3D FE) modeling, in which stress distribution under uniform/non-uniform load, and different resin cement thickness and different elastic modulus of resin composite were analyzed.

Bond durability when applying phosphate ester monomer-containing primers vs. self-adhesive resin cements to zirconia: Evaluation after different aging conditions.

Purpose: This study aimed to evaluate bond durability when applying 2 phosphate ester monomer-containing self-adhesive resin cements alone, versus a combination of phosphate ester monomer-containing primer conditioning plus 2 conventional resin cements requiring primers, to zirconia after different artificial aging methods.

Methods: We cemented air-abraded zirconia plates to composite resin cylinders with self-adhesive resin cements (MS; RU) alone or cemented them with traditional resin cements (ZRV; ZVN) after pre-conditioning with a zirconia primer. A shear bond strength (SBS) test were performed after subjecting them to 19 different aging conditions (n = 15) comprising 30,000× thermocycles, air storage at room temperature (RT), water storage at RT, or at 37 °C for 24 h, 1 week, 1, 3, 6, and 12 months.

Effectiveness of pre-silanization in improving bond performance of universal adhesives or self-adhesive resin cements to silica-based ceramics: Chemical and in vitro evidences.

Objectives: To examine effectiveness of pre-silanization in improving bond performance of multipurpose products such as universal adhesives or self-adhesive resin cements to silica-based ceramics.

Methods: The present study investigated reactions between silanol groups of γ-methacryloxypropyltrimethoxysilane (γ-MPS) and silica, dehydration self-condensation of γ-MPS, and condensation polymerization between γ-MPS and 10-methacryloyloxydecyl dihydrogen phosphate (10-MDP) by using thermodynamic calculations. Shear bond strength (SBS) tests were used to evaluate the influence of pre-silanization on resin bonding when a silane-containing universal adhesive, a silane-unknown universal adhesive, or two self-adhesive resin cements were applied for bonding lithium disilicate to resin.

Effects of Luting Cements and Surface Conditioning on Composite Bonding Performance to Zirconia.

Purpose: This study compared bond strength, durability, and mechanical properties of luting cements for bonding zirconia: a resin-modified glass ionomer cement (RMGIC), a conventional composite cement, and two self-adhesive composite cements.

Materials And Methods: The air-abraded zirconia specimens were assigned to 12 groups (n = 30) to prepare bonded specimens. Classification was based on the pre-conditioning selection: none; primers containing 10-methacryloyloxydecyl dihydrogen phosphate (MDP); universal adhesives containing MDP.

Effect of tribochemical silica coating or multipurpose products on bonding performance of a CAD/CAM resin-based material.

Objectives: Nanocomposite ceramics have been widely used in clinical practice; however, a standard, recommended bonding protocol has not been determined yet. The present study aimed to evaluate application of tribochemical silica coating or multipurpose products on bonding performance of a CAD/CAM resin-based material (known as nanocomposite ceramic).

Materials And Methods: Nanocomposite ceramic specimens were fabricated and assigned into 11 groups to build bonded specimens (n = 15) according to surface treatments (none; air particle abrasion with 50-μm alumina followed by application of a silane coupling agent or a universal adhesive; tribochemical silica coating followed by application of a silane coupling agent or a universal adhesive) and resin luting cements (conventional resin cement, RelyX Veneer; self-adhesive resin cement RelyX Unicem) used.

Effects of multiple firings on mechanical properties and resin bonding of lithium disilicate glass-ceramic.

Objectives: This study aimed to evaluate the effects of different firing cycles on surface hardness, fracture toughness, and roughness of lithium disilicate glass-ceramic, as well as their bond strength to resin.

Materials And Methods: A total of 320 polished lithium disilicate glass-ceramic plates were assigned to four main groups (n = 60) to receive one, two, three, or four firing cycles, respectively. Ceramic plates of the four groups were conditioned with HF acid followed by silanization.