Multi-step influenza forecasting through singular value decomposition and kernel ridge regression with MARCOS-guided gradient-based optimization.

This research delves into the significance of influenza outbreaks in public health, particularly the importance of accurate forecasts using weekly Influenza-like illness (ILI) rates. The present work develops a novel hybrid machine-learning model by combining singular value decomposition with kernel ridge regression (SKRR). In this context, a novel hybrid model known as H-SKRR is developed by combining two robust forecasting approaches, SKRR and ridge regression, which aims to improve multi-step-ahead predictions for weekly ILI rates in Southern and Northern China.

Multi-threshold Image Segmentation based on an improved Salp Swarm Algorithm: Case study of breast cancer pathology images.

Breast cancer poses a significant risk to women's health, and it is essential to provide proper diagnostic support. Medical image processing technology is a key component of all supporting diagnostic techniques, with Image Segmentation (IS) being one of its primary steps. Among various methods, Multilevel Image Segmentation (MIS) is considered one of the most effective and straightforward approaches.

Exploring a novel HE image segmentation technique for glioblastoma: A hybrid slime mould and differential evolution approach.

Glioblastoma is a primary brain tumor with high incidence and mortality rates, posing a significant threat to human health. It is crucial to provide necessary diagnostic assistance for its management. Among them, Multi-threshold Image Segmentation (MIS) is considered the most efficient and intuitive method in image processing.

Enzymolysis kinetics of corn straw by impeded Michaelis model and Box-Behnken design.

Enzymatic hydrolysis is an essential step in the lignocellulosic biorefining process. In this paper, Box-Behnken was used to optimize the enzymatic hydrolysis process of corn stalk, and the promotion effect of three typical surfactants on the enzymatic hydrolysis process was investigated. The experimental results showed that the total reducing sugar yield reached 67.

Peripheral neuropathy associated with chronic lymphoproliferative disorders of natural killer cells (CLPD-NK): a case report and literature review.

Background: Chronic lymphoproliferative disorders of natural killer cells (CLPD-NK) is a rare lymphoproliferative disease. Peripheral neuropathy is an unusual symptom of CLPD-NK. We report a case of peripheral neuropathy associated with CLPD-NK and perform a review of literatures.

Analysis of the clinical features and risk factors of kidney injury in patients with chronic heart failure-a retrospective cohort study.

Background: Heart failure (HF) often leads to kidney injury and increased morbidity and mortality. Factors contributing to kidney injury in HF patients had not been elucidated completely. This study sought to comprehensively evaluate the risk factors and clinical features of kidney injury in patients with chronic heart failure (CHF) and to provide more evidence for the management of these patients.

A few-shot sample augmentation algorithm based on SCAM and DEPS for pump fault diagnosis.

In recent years, pumps have become critical components in agriculture, industry, and the military, necessitating extensive development and implementation of the fault diagnosis method. In the majority of existing fault classification models, the connection between performance improvement and the amount of training data remains high, yet real-world samples are difficult to obtain. Combining domain migration theory and sample expansion method, this paper introduces a few-shot learning fault diagnosis method.

Modified alginate materials for wastewater treatment: Application prospects.

Sodium alginate is a natural macromolecule widely used because of its abundance, low cost of acquisition, and rich hydroxyl and carboxyl groups in the matrix. The physical modification of sodium alginate can be made by blending it with polymer materials. The so-yielded alginate complex is commonly unstable in an aqueous environment due to alginate backbones' high hydrophilicity.

Sodium ions removal by sulfuric acid-modified biochars.

Sulfuric acid modifies the biochar derived from corn cobs, stalks, and reeds. Amongst the modified biochar, corn cobs-biochar has the highest BET (101.6 m g), followed by reeds-biochars (96.

Lignin to value-added products: Research updates and prospects.

Due to the urgent need for renewable and clean energy, the efficient use of lignin is of wide interest. A comprehensive understanding of the mechanisms of lignin depolymerization and the generation of high-value products will contribute to the global control of the formation of efficient lignin utilization. This review explores the lignin value-adding process and discusses the link between lignin functional groups and value-added products.

DRL-Searcher: A Unified Approach to Multirobot Efficient Search for a Moving Target.

This article studies the multirobot efficient search (MuRES) for a nonadversarial moving target problem, whose objective is usually defined as either minimizing the target's expected capture time or maximizing the target's capture probability within a given time budget. Different from canonical MuRES algorithms, which target only one specific objective, our proposed algorithm, named distributional reinforcement learning-based searcher (DRL-Searcher), serves as a unified solution to both MuRES objectives. DRL-Searcher employs distributional reinforcement learning (DRL) to evaluate the full distribution of a given search policy's return, that is, the target's capture time, and thereafter makes improvements with respect to the particularly specified objective.

Remediation of the black-odor water body by aquatic plants with plant growth-promoting Rhizobacteria: Lab and pilot tests.

To explore an effective, environmental, rapid operating method to repair black and odor water bodies, water samples and sediment samples collected from a polluted municipal lake in Daqing, China, were directly tested in transparent barrels (10 L). Seven groups of optimizing parameters obtained the optimal operating method, and the max removal rate of COD, NH-N, NO-N, and TP were achieved (89.18%, 59.

The role of autophagy-related proteins in the pathogenesis of neuromyelitis optica spectrum disorders.

This study aimed to investigate the expression of autophagy-related proteins in a mouse model of neuromyelitis optica (NMO). Mice were assigned to one of four groups: an animal experimental model group (NMO-EAE group, given with exogenous IL-17A), Interleukin-17 monoclonal antibody intervention group (NMO-EAE_0IL17inb), No exogenous interleukin-17 enhanced immune intervention group (NMO-EAE_0IL17), and a control group. Behavioral scores were assessed in each group, and the protein expressions of sequestosome 1 (P62), Beclin-1, the mammalian target of rapamycin (mTOR), phosphoinositide 3-kinase (PI3K-I), and LC3II/LC3I were detected using Western blotting.

SHF confers radioresistance in colorectal cancer by the regulation of mitochondrial DNA copy number.

Altered mitochondrial function contributes greatly to pathogenesis and progression of colorectal cancer. In this study, we report a functional pool of Src homology 2 domain-containing F (SHF) in mitochondria controlling the response of colorectal cancer cells to radiation therapy. We found that elevated expression of SHF in cancer cells is essential for promoting mitochondrial function by increasing mitochondrial DNA copy number, thus reducing the sensitivity of colorectal cancer cells to radiation.

Enzymes and enzymatic mechanisms in enzymatic degradation of lignocellulosic biomass: A mini-review.

Enzymatic hydrolysis is the key step limiting the efficiency of the biorefinery of lignocellulosic biomass. Enzymes involved in enzymatic hydrolysis and their interactions with biomass should be comprehended to form the basis for looking for strategies to improve process efficiency. This article updates the contemporary research on the properties of key enzymes in the lignocellulose biorefinery and their interactions with biomass, adsorption, and hydrolysis.

A Retrospective Study of the Clinical Characteristics of Japanese Encephalitis in Adults.

Objective: This study aimed to explore the diagnostic points and treatment modes of the clinical characteristics of Japanese encephalitis (JE) in the middle-aged and elderly population.

Methods: Six patients aged 47-72 who were diagnosed with JE at the Beijing Chaoyang Hospital Affiliated with the Capital Medical University between August 2018 and September 2019 were enrolled in the study. Their clinical manifestations, biochemical indicators, imaging data, diagnostic methods, and the evolution and outcomes of the treatments they underwent were retrospectively analyzed.

Nitrogen removal from low C/N wastewater in a novel Sharon&DSR (denitrifying sulfide removal) reactor.

Denitrification reactions commonly remove nitrate and other reactive nitrogen (Nr) from wastewater. The C/N ratio indicates the sufficiency of organic carbons to drive heterotrophic denitrification; a low C/N ratio frequently leads to poor denitrification performance in wastewater treatment. This study proposed and tested a novel Sharon&DSR (denitrifying sulfide removal) process, with nitrite generated by the Sharon reactions and sulfide from sulfur-reducing reactions for promoting the following nitrite-based denitrification and denitrifying sulfide removal (DSR) process.

FKBP4 regulates 5-fluorouracil sensitivity in colon cancer by controlling mitochondrial respiration.

Mitochondrial respiration and metabolism play a key role in the pathogenesis and progression of colon adenocarcinoma (COAD). Here, we report a functional pool of FKBP4, a co-chaperone protein, in the mitochondrial intermembrane space (IMS) of colon cancer cells. We found that IMS-localized FKBP4 is essential for the maintenance of mitochondrial respiration, thus contributing to the sensitivity of COAD cells to 5-fluorouracil (5-FU).

Inhibitor formation and detoxification during lignocellulose biorefinery: A review.

For lignocellulose biorefinery, pretreatment is needed to maximize the cellulose accessibility, frequently generating excess inhibitory substances to decline the efficiency of the subsequent fermentation processes. This mini-review updates the current research efforts to detoxify the adverse impacts of generated inhibitors on the performance of biomass biorefinery. The lignocellulose pretreatment processes are first reviewed.

A novel mitochondria-related gene signature for controlling colon cancer cell mitochondrial respiration and proliferation.

Colon cancer cells rely on mitochondrial respiration as major source of energy for supporting their proliferation and invasion, thus promoting colon cancer malignancy and progression. In this study, we comprehensively investigated the prognostic significance of mitochondria-related genes in colon cancer and identified the hub genes that control colon cancer cell mitochondrial respiration and proliferation. We first systematically evaluated the prognostic significance of differentially expressed mitochondria-related genes in colon cancer specimens.

Revealing potential immunotherapy targets through analysis of a ceRNA network in human colon adenocarcinoma.

Background: Microsatellite instability-high (MSI-H) is a special type of human colon adenocarcinoma (COAD) that responds well to immunotherapy. MicroRNAs (miRNAs) and long non-coding RNAs (lncRNAs), which are important members of competing endogenous RNAs (ceRNAs) networks, are involved in the tumorigenesis and development of MSI-H COAD. This study aimed to establish a ceRNA network for MSI in COAD to identify targets and prognostic markers that may explain the effects of immunotherapy.

Contemporary proteomic research on lignocellulosic enzymes and enzymolysis: A review.

This review overviewed the current researches on the isolation of novel strains, the development of novel identification protocols, the key enzymes and their synergistic interactions with other functional enzyme systems, and the strategies for enhancing enzymolysis efficiencies. The main obstacle for realizing biorefinery of lignocellulosic biomass to biofuels or biochemicals is the high cost of enzymolysis stage. Therefore, research prospects to reduce the costs for lignocellulose hydrolysis were outlined.

Influence of polyethylene-microplastic on environmental behaviors of metals in soil.

Microplastics (MPs) in terrestrial ecosystems have attracted increasing attention all over the world. The adsorption-desorption behavior and bioavailability of metals in soil would affect its toxicity to organisms. However, the influences of MPs on adsorption-desorption behavior between metals and soil as well as bioavailability of metals in soils are scarcely investigated.

Genomic studies on natural and engineered aquatic denitrifying eco-systems: A research update.

Excess nitrogenous compounds in municipal or industrial wastewaters can stimulate growth of denitrifying bacteria, in return, to convert potentially hazardous nitrate to inorganic nitrogen gas. To explore the community structure, distributions and succession of functional strains, and their interactions with other microbial communities, contemporary studies were performed based on detailed genomic analysis. This mini-review updated contemporary genomic studies on denitrifying genes in natural and engineered aquatic systems, with the constructed wetlands being the demonstrative system for the latter.