Publications by authors named "Honglian Wei"
Mediation by sulphate-reducing bacteria (SRB) is responsible for pyrite (FeS) formation. The origin of the Dachang tin polymetallic ore field is related to the mineralisation of submarine hydrothermal vent sediments. Here, we investigated SRB in these ores via morphological, chemical, and isotopic analyses.
View Article and Find Full Text PDFPurpose: To shorten the turnaround time for blood culture (BC) analyses, a rapid method was developed for the direct identification, antimicrobial susceptibility testing (AST), and multidrug resistance testing of bacteria-positive BCs.
Materials And Methods: The mixtures in BC bottles were treated with the multistep centrifugation method developed here and the conventional culture-based method. The bacterial sediment obtained after centrifugation was analyzed directly with MALDI-TOF MS and Vitek 2 Compact, and AST was performed directly with the Kirby-Bauer (K-B) disk diffusion, VITEK 2 Compact, and E-test methods.
Objective: Clostridioides difficile may colonize healthy infants and young children asymptomatically and for the long-term. C. difficile genotypes and the rate and determinants of colonization differ substantially and vary among countries and regions.
View Article and Find Full Text PDFArticle Synopsis
- Clostridioides difficile is commonly found in healthy infants, with a colonization rate of 22.8% observed in a study of 1,098 Chinese infants, revealing a significant presence of toxigenic strains.
- The study identified various strains, with the dominant PCR-ribotype HB03 comprising nearly 20% of isolates, highlighting the diversity of C. difficile in this population.
- Findings indicated a link between higher colonization rates and factors like age and prior hospitalization, while also raising concern over growing antibiotic resistance, particularly to rifamycin.
Clostridium difficile is the causative pathogen for antibiotic-related nosocomial diarrhea. For epidemiological study and identification of virulent clones, a new binary typing method was developed for C. difficile in this study.
View Article and Find Full Text PDFObjectives: To clarify the role of Golgi membrane glycoprotein 73 (gp73) in evaluating the progression of chronic hepatitis B virus (HBV) infection.
Design And Methods: Participants included 958 controls, 421 chronic hepatitis B, 944 hepatic cirrhosis, and 127 hepatocellular carcinoma (HCC) patients. All the patients, with the exception of the controls, were diagnosed HBsAg positive.
Non-alcoholic fatty liver disease (NAFLD) is characterized by triglyceride (TG) accumulation in hepatocytes. Very low density lipoprotein (VLDL) is a major secretory product of the liver that transports endogenously synthesized TG. Disrupted VLDL secretion may contribute to the accumulation of TG in hepatocytes.
View Article and Find Full Text PDFBackgrounds: The mucosa of gallbladder stimulated with gallstones and accompanied with abnormalities in bile composition, is the origin of biliary disease, which could induce metaplasia, simple hyperplasia, atypical hyperplasia and even carcinoma in situ and invasive carcinoma in gallbladder mucosa.
Methods: To determine the disorder of the balance between cell proliferation and cell cycle or apoptosis in gallbladder cancer accompanied with gallstones, removal of the gallbladder due to gallstones specimens of 88 cases were collected randomly, including a variety of 54 cases for hyperplasia, 27 cases for gallbladder cancer and 7 cases for normal gallbladder. The expressions of key cell cycle factors were detected by in situ hybridization, immunohistochemistry and Western blot.
Objective: To explore the growth inhibition and apoptosis-inducing effects of phytic acid in human gastric cancer SGC-7901 cells.
Methods: The growth inhibition action of phytic acid on SGC-7901 cells was examined by MTT assay. AO/EB fluorescence staining and DNA ladder assay were applied to study the proapoptosis effects of phytic acid.