Tuning Phase Transition of Molecular Self-Assembly by Artificial Chaperones through Aromatic-Aromatic Interactions.

The molecular chaperones are essential and play significant roles in controlling the protein phase transition and maintaining physiological homeostasis. However, manipulating phase transformation in biomimetic peptide self-assembly is still challenging. This work shows that an artificial chaperone modulates the energy landscape of supramolecular polymerization, thus controlling the phase transition of amyloid-like assemblies from crystals to hydrogels to solution.

Cu-Mediated CO Coordination for Promoting C-C Coupling for CO and CO Electroreduction.

Selective electrochemical upgrading of CO to multicarbon (C) products requires a C-C coupling process, yet the underlying promoting mechanism of widely involved Cu oxidation states remains largely unclear, hindering the subtle design of efficient catalysts. Herein, we unveil the critical role of Cu in promoting C-C coupling via coordination with a CO intermediate during electrochemical CO reduction. We find that, relative to other halogen anions, iodide (I) in HCO electrolytes accelerates the generation of strongly oxidative hydroxyl radicals that accounts for the formation of Cu, which can be dynamically stabilized by I via the formation of CuI.

An eye- tracking technology and MLP-based color matching design method.

Images are a significant source of inspiration for designers to carry out the color design. However, the absence of animated images in the product color design can create confusion for designers. To translate the colours of the animated images into product colours, this work used eye-tracking technology to aid colour extraction and the multilayer perceptron neural network (MLP) algorithm to train a product colour decision model to filter the best product colour schemes.

Confinement of Assemblies of Peptides by Chemical Reactions in Living Cells.

The self-assembly of peptides plays an important role in optics, catalysis, medicine, and disease treatment. In recent years, peptide-based materials have exhibited great potential for cancer therapy and disease imaging due to their excellent biocompatibility, structural tenability, and ease of functionality. Peptides could self-assemble into diverse nanostructures in vivo triggered by endogenous stimuli, which initiated chemical reactions and self-assembled to achieve desired biological functions in the tumor microenvironment.

Triggered Self-Sorting of Peptides to Form Higher-Order Assemblies in a Living System.

Biological components (protein, DNA, lipid rafts, etc.) self-sort to form higher-order structures with elegant modulation by endogenous stimuli for maintaining cellular functions in living cells. However, the challenge of producing self-sorted higher-order assemblies of peptides in living systems (cells and tissues) spatiotemporally has yet to be achieved.

Controlling Intracellular Enzymatic Self-Assembly of Peptide by Host-Guest Complexation for Programming Cancer Cell Death.

Controlling the enzymatic reaction of macromolecules in living systems plays an essential role in determining the biological functions, which remains challenging in the synthetic system. This work shows that host-guest complexation could be an efficient strategy to tune the enzymatic self-assembly of the peptide. The formed host-guest complexation prevents the enzymatic kinetics of peptide assemblies on the cell surface and promotes cellular uptake of assemblies.

Hydroxyl radicals dominate reoxidation of oxide-derived Cu in electrochemical CO reduction.

Cu sites on the surface of oxide-derived copper (OD-Cu) are of vital importance in electrochemical CO reduction reaction (CORR). However, the underlying reason for the dynamically existing Cu species, although thermodynamically unstable under reductive CORR conditions, remains uncovered. Here, by using electron paramagnetic resonance, we identify the highly oxidative hydroxyl radicals (OH) formed at room temperature in HCO solutions.

Controlling supramolecular filament chirality of hydrogel by co-assembly of enantiomeric aromatic peptides.

Supramolecular chirality plays an indispensable role in living and synthetic systems. However, the generation and control of filament chirality in the supramolecular hydrogel of short peptides remains challenging. In this work, as the first example, we report that the heterodimerization of the enantiomeric mixture controls the alignment, chirality, and stiffness of fibrous hydrogels formed by aromatic building blocks.

Molecular-Scale Insights into Electrochemical Reduction of CO on Hydrophobically Modified Cu Surfaces.

Depressing the competitive hydrogen evolution reaction (HER) to promote current efficiency toward carbon-based chemicals in the electrocatalytic CO reduction reaction (CORR) is desirable. A strategy is to apply the hydrophobically molecular-modified electrodes. However, the molecular-scale catalytic process remains poorly understood.

Spatiotemporal Control over Chemical Assembly in Living Cells by Integration of Acid-Catalyzed Hydrolysis and Enzymatic Reactions.

Spatiotemporal control of chemical assembly in living cells remains challenging. We have now developed an efficient and general platform to precisely control the formation of assemblies in living cells. We introduced an O-[bis(dimethylamino)phosphono]tyrosine protection strategy in the self-assembly motif as the Trojan horse, whereby the programmed precursors resist hydrolysis by phosphatases on and inside cells because the unmasking of the enzymatic cleavage site occurs selectively in the acidic environment of lysosomes.

In Situ Construction of Functional Assemblies in Living Cells for Cancer Therapy.

Peptide-based materials hold great promise for various biomedical applications and have drawn increasing attention over the past five years. Despite the progress in fabrication and handling peptide materials in vitro, manipulating assemblies of peptides in living cells (or animals) is still in its infancy. In this contributing review, recent work is summarized using endogenous triggers to construct functional assemblies of peptides in vivo.

Dynamically loading IFC models on a web browser based on spatial semantic partitioning.

Industry foundation classes (IFC) is an open and neutral data format specification for building information modeling (BIM) that plays a crucial role in facilitating interoperability. With increases in web-based BIM applications, there is an urgent need for fast loading large IFC models on a web browser. However, the task of fully loading large IFC models typically consumes a large amount of memory of a web browser or even crashes the browser, and this significantly limits further BIM applications.

3D2SeqViews: Aggregating Sequential Views for 3D Global Feature Learning by CNN With Hierarchical Attention Aggregation.

Learning 3D global features by aggregating multiple views is important. Pooling is widely used to aggregate views in deep learning models. However, pooling disregards a lot of content information within views and the spatial relationship among the views, which limits the discriminability of learned features.

[Secondary male hypogonadism induced by sellar space-occupying lesion: Clinical analysis of 22 cases].

Objective: To analyze the clinical characteristics of secondary male hypogonadism induced by sellar space-occupying lesion, explore its pathogenesis, and improve its diagnosis and treatment.

Methods: We retrospectively analyzed the clinical data about 22 cases of secondary male hypogonadism induced by sellar space-occupying lesion, reviewed related literature, and investigated the clinical manifestation, etiological factors, and treatment methods of the disease. Hypogonadism developed in 10 of the patients before surgery and radiotherapy (group A) and in the other 12 after it (group B).