Publications by authors named "Hongle Zhao"

Article Synopsis
  • This study explores the potential causal link between varicocele and male infertility using a two-sample Mendelian randomization (MR) approach, aiming to provide clearer evidence beyond previous retrospective studies.
  • Researchers analyzed data from the GEO database and the IEU GWAS database, applying various MR methods to assess the relationship while controlling for confounding factors.
  • Key findings revealed that the gene MEGF9 is significantly associated with male infertility, and its expression increases in varicocele models but decreases after treatment, indicating its potential as a therapeutic target.
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The aim of this retrospective study was to identify the perioperative incidence and risk factors of venous thromboembolism (VTE) in patients undergoing surgery for cervical cancer. The retrospective medical records of consecutive patients with cervical cancer were collected at the Qianfoshan Hospital affiliated with Shandong University from July 2014 to July 2017. Basic information regarding the patients, as well as tumor and surgery-related factors were compared between the cervical cancer patients with and without VTE.

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Objective: To investigate the effect of Bushen Huoxue Recipe (BHR) on cyclophosphamide-induced apoptosis of testicular spermatogenic cells in mice and its possible action mechanisms.

Methods: Fifty male Babl/c mice aged 8-9 weeks were randomly divided into five groups of an equal number: blank control, model control, low-dose BHR, medium-dose BHR and high-dose BHR. The animals in the blank control group were intraperitoneally injected with normal saline, while those in the other four groups with cyclophosphamide at 50 mg/kg/d, all for 7 days.

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Objective: To study the safety and efficacy of Bushen Daozhuo Granules (BDG) in the treatment of type Ⅲ prostatitis.

Methods: This multicenter randomized controlled clinical trial included 478 patients with type Ⅲ prostatitis, 290 in the trial group and 188 as controls, the former treated with BDG at 200 ml bid and the latter with tamsulosin hydrochloride sustainedrelease capsules at 0.2 mg qd, both for 4 weeks.

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Yangjing capsule (YC), a traditional Chinese compound herbal preparation, has been proven as an effective drug to improve spermatogenesis in clinical practice. However, its pharmacological mechanisms were not fully clarified. This study was designed to investigate the protective effects of YC on spermatogenesis in the mouse model of spermatogenesis dysfunction induced by cyclophosphamide (CP).

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Yangjing Capsule (YC), an innovative Chinese medicine based on traditional prescription, promotes testosterone synthesis by upregulating the expression of steroidogenic enzymes. Nur77 as a nuclear receptor is known to regulate the expression of many steroid synthetases. This study aimed to explore the potential mechanisms by which YC regulates testosterone synthesis in Leydig cells.

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