Publications by authors named "Hongkun Tan"
Background: Although the lactate pathway has been reported to lead to immune escape through the inhibition of effector T cells, the cancer-intrinsic lactate signature has not been identified, and the immunotherapeutic efficacy and potential mechanism of the lactate signature are still unclear.
Methods: We defined a pan-cancer up-lactate score by comparing malignant tissues and normal tissues in the TCGA cohort. The immunotherapeutic efficacy was evaluated in non-small cell lung cancer (NSCLC), metastatic renal cancer (mRCC), bladder cancer (BLCA) and melanoma cohorts.
An amendment to this paper has been published and can be accessed via the original article.
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- Neisseria meningitidis causes bacterial meningitis, which can be deadly, highlighting the need for rapid and cost-effective diagnostic tools, particularly in economically disadvantaged regions.
- A pooled-analysis of 14 studies showed that the loop-mediated isothermal amplification (LAMP) assay has high sensitivity (94%) and specificity (100%) for detecting meningococcus, indicating strong diagnostic accuracy.
- The LAMP assay is an affordable and user-friendly alternative to traditional methods like bacterial culture and PCR, making it suitable for use in areas with limited resources.
Background: At present, the infection and prevalence rates of tuberculosis (TB) are still high in worldwide. The Xpert MTB/RIF technology has improved the diagnosis speed of Mycobacterium tuberculosis (MTB) and facilitated the rapid treatment of TB patients.
Methods: We searched experimental data derived from Xpert MTB/RIF for detecting MTB in gastric aspirates in PubMed, Embase, Web Of Science, and the Cochrane Library databases between January 2012 to April 2019.
Background: Tuberculous meningitis (TBM) is one of the most serious types of extrapulmonary tuberculosis. However, low sensitivity of culture of cerebrospinal fluid (CSF) increases the difficulty in clinical diagnosis, leading to diagnostic delay, and misdiagnosis. Xpert MTB/RIF assay is a rapid and simple method to detect tuberculosis.
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