Ubiquitin ligase TRIM15 promotes the progression of pancreatic cancer via the upregulation of the IGF2BP2-TLR4 axis.

Background: The tripartite motif family, predominantly characterized by its E3 ubiquitin ligase activities, is involved in various cellular processes including signal transduction, apoptosis and autophagy, protein quality control, immune regulation, and carcinogenesis. Tripartite Motif Containing 15 (TRIM15) plays an important role in melanoma progression through extracellular signal-regulated kinase activation; however, data on its role in pancreatic tumors remain lacking. We previously demonstrated that TRIM15 targeted lipid synthesis and metabolism in pancreatic cancer; however, other specific regulatory mechanisms remain elusive.

Dual passivation effects of ionic liquids enable efficient and stable perovskite solar cells.

In recent years, perovskite solar cells (PSCs) have been attracting more and more attention. Although perovskite materials have high defect tolerance, defects remain the main factor that seriously affects the efficiency and stability of PSCs. Herein, the ionic liquid of 1-butyl, 3-methylimidazolium acetate ([BMIM][ACO]) was introduced into the SnO/perovskite interface for the first time.

Stable α-FAPbI via porous PbI for efficient perovskite solar cells.

Black-phase formamidinium lead iodide (FAPbI), with a narrow bandgap and high thermal stability, has emerged as an in-demand material for highly efficient perovskite solar cells (PSCs). In a two-step sequential deposition, the PbI film plays an important role in the formation of a perovskite film with desirable qualities. This paper explores using N-methyl-2-pyrrolidone (NMP), a strong Lewis base, and N,N-dimethylformamide (DMF) as a mixed precursor solvent (DMF/NMP) of PbI and reports on preparing PbI films with a porous morphology by thermal treatment.

ITGA2 induces STING expression in pancreatic cancer by inducing DNMT1 degradation.

Purpose: Integrin alpha 2 (ITGA2, also known as CD49b or VLA-2) is the alpha subunit of a transmembrane receptor for collagens and related proteins. Previously, we found that ITGA2 may regulate immune cell infiltration in pancreatic cancer by inducing PD-L1 expression. As yet, however, whether ITGA2 regulates immune cell infiltration in pancreatic cancer by other mechanisms remains unclear.

CBX3 Regulated By YBX1 Promotes Smoking-induced Pancreatic Cancer Progression via Inhibiting SMURF2 Expression.

As a key reversible and heritable mechanism of transcriptional regulation, the epigenetic modification plays a crucial role in tumorigenesis. Of note, tobacco smoking induces epigenetic modifications to promote pancreatic cancer development. Chromobox protein homolog 3 (CBX3) acts as an epigenetic regulator, modulating gene expression of downstream targets via chromatin modifications.

Overexpressed integrin alpha 2 inhibits the activation of the transforming growth factor β pathway in pancreatic cancer via the TFCP2-SMAD2 axis.

Background: Integrin alpha 2 (ITGA2) has been recently reported to be an oncogene and to play crucial roles in tumor cell proliferation, invasion, metastasis, and angiogenesis. Our previous study showed that ITGA2 was overexpressed in pancreatic cancer and promoted its progression. However, the mechanism of ITGA2 overexpression and other mechanisms for promoting the progression of pancreatic cancer are still unclear.

Ionic Liquids Modulating CsPbI Colloidal Quantum Dots Enable Improved Mobility for High-Performance Solar Cells.

Colloidal all-inorganic CsPbI perovskite quantum dots (PQDs) have shown tremendous potential in photovoltaic applications in recent years due to their outstanding optoelectronic properties that general metal halide perovskites offer, along with the added advantages that originates from size reduction and the quantum confinement effect. However, the issue of low carrier mobility in PQD films caused by insulating organic ligands capped on the PQD surface still remains to be addressed while aiming for high-efficiency PQD solar cells. Herein, we propose a novel strategy that takes benefits of ionic liquids, which can offer the high polarity and the electron donating ability to boost the mobility of PQD films in photovoltaic devices.

Cu-Ion-Implanted and Polymeric Carbon Nitride-Decorated TiO Nanotube Array for Unassisted Photoelectrochemical Water Splitting.

Photoelectrochemical (PEC) water splitting over TiO photoanodes is a promising strategy for hydrogen production due to its eco-friendly, energy-saving, and low-cost nature. However, the intrinsic drawbacks of TiO, ., the too wide band gap and rapid exciton recombination, significantly limit further enhancement of its performance.

Dimensional structure regulation of organic-inorganic hybrid perovskite and its application in thin film transistors.

The effects of dimensional structure on the properties of lead iodide perovskite (CHNH)(CHNH)PbIwere investigated. Furthermore, perovskite thin films with different dimensionalities were applied as the channel layer of thin film transistors (TFT). The electrical performance and stability of TFT devices were significantly improved through the regulation of dimensional microstructure of the perovskites.

CHNHPbBrI Quantum Dots Enhance Bulk Crystallization and Interface Charge Transfer for Efficient and Stable Perovskite Solar Cells.

Obtaining a perovskite light-absorbing layer with good crystallization, low defect concentration, good stability, and well-matched energy levels is critical to obtaining high-efficiency perovskite solar cells (PSCs). Here, a hybrid PSC with a graded band gap is explored using MAPbBr (MA = CHNH) and MAPbBrI quantum dots (QDs) as component cells. We have creatively designed a solar cell device with a double-QD structure [indium tin oxide (ITO)/SnO/perovskite:MAPbBr QDs/MAPbBrI QDs/Spiro-OMeTAD/Au].

Perovskite Ink with an Ultrawide Processing Window for Efficient and Scalable Perovskite Solar Cells in Ambient Air.

Perovskite solar cells (PSCs) have attracted tremendous attention because of their rapidly growing efficiency and low cost. However, the efficiency of scalably deposited PSCs, especially spray-coated devices, is still lagging far behind that of spin-coated devices because of the complicated crystallization of coated precursor ink. Here, we show a precursor ink with an ultrawide processing window (more than 40 min) for spray-coating by adjusting the precursor component, which benefits the scalable deposition of perovskite films.

Efficient Perovskite Solar Cells Prepared by Hot Air Blowing to Ultrasonic Spraying in Ambient Air.

Substrate heating is the most common method for controlling crystallization during spray coating. However, due to poor controllability during substrate heating, the sprayed films have variable thicknesses and rich pores, which limit the efficiency of the device. Here, hot air blowing was applied to spray coating to promote the crystallization of perovskite films under ambient conditions.

UV-Sintered Low-Temperature Solution-Processed SnO as Robust Electron Transport Layer for Efficient Planar Heterojunction Perovskite Solar Cells.

Recently, low temperature solution-processed tin oxide (SnO) as a versatile electron transport layer (ETL) for efficient and robust planar heterojunction (PH) perovskite solar cells (PSCs) has attracted particular attention due to its outstanding properties such as high optical transparency, high electron mobility, and suitable band alignment. However, for most of the reported works, an annealing temperature of 180 °C is generally required. This temperature is reluctantly considered to be a low temperature, especially with respect to the flexible application where 180 °C is still too high for the polyethylene terephthalate flexible substrate to bear.

Enhanced planar perovskite solar cells with efficiency exceeding 16% via reducing the oxygen vacancy defect state in titanium oxide electrode.

In this work, the influence of oxygen vacancy defect (OVD) in compact titanium oxide (c-TiO) on the performance of planar perovskite solar cells (p-PSCs) is investigated, and the possible mechanisms are also proposed. To meet our objective, anatase c-TiO thin films with various OVD concentrations are prepared by changing the oxygen flux during the DC magnetron sputtering process and are characterized by the intensity of defect signals in the X-ray photoelectron spectra. We conclude that abundant OVDs can trigger an obviously increased majority carrier accumulation zone at the metal oxide/perovskite interface and enhanced capacitance, thereby greatly deteriorating photogenerated carrier collection efficiency.

Improving Performance of Organic-Silicon Heterojunction Solar Cells Based on Textured Surface via Acid Processing.

Unlabelled: Poly(3,4-ethylenedioxythiophene):poly(styrenesulfonate) (

Pedot: PSS) is widely applied in organic-photoelectronic devices due to its excellent transparency and conductivity. However, when it is used in the organic-silicon heterojunction solar cells with traditional pyramid texturing surface, the device performance is limited by the contact between the

Pedot: PSS and silicon wafer at the bottom of the pyramids. We optimized the structure of the bottom of the pyramids via acid isotropic etching (AIE) method with mixed acid solution to ensure that the silicon wafer is fully covered by the

Pedot: PSS.

Novel Combination of Efficient Perovskite Solar Cells with Low Temperature Processed Compact TiO2 Layer via Anodic Oxidation.

In this work, a facile and low temperature processed anodic oxidation approach is proposed for fabricating compact and homogeneous titanium dioxide film (AO-TiO2). In order to realize morphology and thickness control of AO-TiO2, the theory concerning anodic oxidation (AO) is unveiled and the influence of relevant parameters during the process of AO such as electrolyte ingredient and oxidation voltage on AO-TiO2 formation is observed as well. Meanwhile, we demonstrate that the planar perovskite solar cells (p-PSCs) fabricated in ambient air and utilizing optimized AO-TiO2 as electron transport layer (ETL) can deliver repeatable power conversion efficiency (PCE) over 13%, which possess superior open-circuit voltage (Voc) and higher fill factor (FF) compared to its counterpart utilizing conventional high temperature processed compact TiO2 (c-TiO2) as ETL.

Toward Revealing the Critical Role of Perovskite Coverage in Highly Efficient Electron-Transport Layer-Free Perovskite Solar Cells: An Energy Band and Equivalent Circuit Model Perspective.

Currently, most efficient perovskite solar cells (PVKSCs) with a p-i-n structure require simultaneously electron transport layers (ETLs) and hole transport layers (HTLs) to help collecting photogenerated electrons and holes for obtaining high performance. ETL free planar PVKSC is a relatively new and simple structured solar cell that gets rid of the complex and high temperature required ETL (such as compact and mesoporous TiO2). Here, we demonstrate the critical role of high coverage of perovskite in efficient ETL free PVKSCs from an energy band and equivalent circuit model perspective.