Publications by authors named "Hongjiong Zhang"
Article Synopsis
- Unipotent basal and luminal stem cells are essential for maintaining prostate health, with a newly identified intermediate population (Basal-B) emerging during inflammation or cancer.
- Basal-B cells show increased organoid formation capabilities and are considered a temporary basal stem cell state influenced by androgen levels and JAK/STAT signaling.
- The study highlights that inflammation promotes the transition of Basal-B cells to luminal cells, while inhibiting JAK/STAT signaling can lessen this transition and potentially impacts prostate disease development like neoplasia.
Organ development, regeneration and cancer initiation are typically influenced by the proliferation and lineage plasticity of tissue-specific stem cells. Prostate intermediate cells, which exhibit characteristics of both basal and luminal cells, are prevalent in pathological states and during organ development. However, the identity, fate and function of these intermediate cells in prostate development are not well understood.
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