Monocarboxylate transporter 4 promotes the migration of non‑cancerous L929 fibroblast cells by activating the IGF1/IGF1R/PIK3R3/SGK1 axis.

The tumor microenvironment (TME) and Warburg effect are critical for the regulation of tumor metastasis. The monocarboxylate transporter (MCT) family members, particularly MCT4, which is encoded by the solute carrier family 16 member 3 gene, play an important role in the regulation of the TME and mediation of the Warburg effect by transporting lactate out of cancer cells. Migration and invasion are two key features of metastasis.

Overexpression of monocarboxylate transporter 4 promotes the migration and invasion of non-carcinogenic L929 fibroblast cells.

Metastasis is a primary contributor to the low survival rates of patients with cancer. Enhanced migration and invasion are two key features of the metastatic transformation of cancer cells. Furthermore, despite the fact that overexpression of the monocarboxylate transporter (MCT)1 and 4 proteins has been found to promote the migration or invasion of cancer cells, previous findings have not been conclusive and have even been contradictory.

Chiral carbonaceous nanotubes containing twisted carbonaceous nanoribbons, prepared by the carbonization of chiral organic self-assemblies.

Single-handed helical silica nanotubes containing chiral organic self-assemblies were prepared by using a supramolecular templating approach. After carbonization and the removal of the silica, single-handed helical carbonaceous nanotubes that contained twisted carbonaceous nanoribbons were obtained. It is believed that the nanotubes formed as a result of the adsorption of low-molecular-weight gelators.