Publications by authors named "Hongjing Ai"
Article Synopsis
- PathClustNet is a new pathway-based clustering algorithm developed to classify cancer subtypes by analyzing gene clusters and their associated pathways.
- The study applied this algorithm to data from the TCGA pan-cancer project, identifying four distinct cancer subtypes (C1, C2, C3, and C4), each with unique characteristics related to metabolism, immune response, genomic stability, and mutation rates.
- Age, smoking, viral infections, and alcohol use were found to impact various pathway activities, highlighting the importance of understanding tumor heterogeneity for precision oncology.
Objective: To investigate the associations between dynapenic obesity and the risk of dementia, and the modifying effects of age, sex, and the APOE gene, using a large population-based cohort.
Methods: 279,884 participants aged 55 and above from the UK Biobank were included. The participants were classified into four categories based on body mass index and hand grip strength: healthy, obesity, dynapenia, and dynapenic obesity.
Background: Intratumor heterogeneity (ITH) plays a crucial role in tumor progression, relapse, immune evasion, and drug resistance. Existing ITH quantification methods based on a single molecular level are inadequate to capture ITH evolving from genotype to phenotype.
Methods: We designed a set of information entropy (IE)-based algorithms for quantifying ITH at the genome (somatic copy number alterations and mutations), mRNA, microRNA (miRNA), long non-coding RNA (lncRNA), protein, and epigenome level, respectively.
Background: Although numerous studies have explored the impact of meteorological factors on the epidemic of COVID-19, their relationship remains controversial and needs to be clarified.
Methods: We assessed the risk effect of various meteorological factors on COVID-19 infection using the distributed lag nonlinear model, based on related data from July 1, 2020, to June 30, 2021, in eight countries, including Portugal, Greece, Egypt, South Africa, Paraguay, Uruguay, South Korea, and Japan, which are in Europe, Africa, South America, and Asia, respectively. We also explored associations between COVID-19 prevalence and individual meteorological factors by the Spearman's rank correlation test.
Fast determination of tetrafluoroborate by high-performance liquid chromatography using a silica-based monolithic column and direct conductivity detection was carried out. Chromatographic separation was performed on a Chromolith Speed ROD RP-18e column (50 mm x 4.6 mm i.
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