Publications by authors named "Hongjin An"
Background: Increasing evidence suggests that immunophenotypes play a crucial role in Metabolic dysfunction-associated fatty liver disease (MAFLD), but the specific immunophenotypes contributing to its pathogenesis remain unclear.
Objectives: This study aimed to elucidate the causal associations between immunophenotypes and MAFLD and identify the underlying mediation pathways involved.
Design: Mendelian randomization (MR) study.
Glucagon-like peptide-1 receptor agonists and the risk of erectile dysfunction: a drug target Mendelian randomization study.
Front Endocrinol (Lausanne)
November 2024
Background: Glucagon-like peptide-1 receptor agonists (GLP-1RAs) have been widely used for type 2 diabetes (T2D) and weight management. However, the causal relationship of GLP-1RAs with erectile dysfunction (ED) was still unclear.
Methods: Mendelian randomization (MR) analysis was conducted to reveal the association of genetically proxied GLP-1RAs with ED.
Article Synopsis
- - Atherosclerotic plaques lead to serious heart diseases, driven by oxidative stress, lipid issues, and ongoing inflammation, but current drugs only target individual problems rather than the whole issue.
- - Researchers developed a new treatment called Lip@HS, which combines a gas therapy with a specialized nanozyme that specifically targets harmful cells in atherosclerotic plaques.
- - This new approach uses ultrasound to activate the nanozyme, enhancing lipid metabolism and reducing inflammation, showing promise as a comprehensive treatment for atherosclerosis.
Objectives: The association between systemic lupus erythematosus (SLE) and primary biliary cholangitis (PBC) has been increasingly recognized. However, the existence of causal connections between SLE and PBC has yet to be established. In this study, we aimed to investigate the bidirectional causation between SLE and PBC utilizing Mendelian randomization (MR) analysis.
View Article and Find Full Text PDFBackground: Individuals with inflammatory bowel disease (IBD) exhibit a heightened likelihood of developing erythema nodosum (EN), but the presence of causal link is unknown. The purpose of the present research was to investigate this connection using a bidirectional two-sample Mendelian randomization (MR) analysis.
Methods: Summarized statistics for EN were sourced from the FinnGen consortium of European ancestry.
Self-Reinforced Bimetallic Mito-Jammer for Ca Overload-Mediated Cascade Mitochondrial Damage for Cancer Cuproptosis Sensitization.
Adv Sci (Weinh)
April 2024
Article Synopsis
- Excessive reactive oxygen species (ROS), metal ion buildup, and dysfunction in the tricarboxylic acid cycle are key factors leading to cell death in mitochondria, which poses challenges for cancer treatment.
- A new self-reinforced bimetallic Mito-Jammer combines doxorubicin and calcium peroxide with metal-organic frameworks to target tumors more effectively by generating ROS in the tumor environment.
- This innovative approach not only amplifies mitochondrial damage and reduces ATP levels to enhance tumor cell death but also promotes immune responses and inhibits tumor spreading.
Background And Aims: This study aimed to investigate the incidence and the risk factors of incidence for second primary malignancies (SPMs) onset among survivors diagnosed with colorectal cancer (CRC).
Methods: A large population-based cohort study was performed. Data of patients diagnosed with CRC was identified and extracted from 8 cancer registries of Surveillance, Epidemiology, and End Results database from January 1990 to December 2017.
Measles Outbreak among Previously Immunized Adult Healthcare Workers, China, 2015.
Can J Infect Dis Med Microbiol
July 2016
Measles is caused by measles virus belonging to genus Morbillivirus of the family Paramyxoviridae. Vaccination has played a critical role in controlling measles infection worldwide. However, in the recent years, outbreaks of measles infection still occur in many developing countries.
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