Triaxial mechanical behaviours and life cycle assessment of sustainable multi-recycled aggregate concrete.

Multi-recycling of concrete waste presents a promising avenue for carbon-negative development and a circular economy. This study comprehensively assesses the triaxial mechanical performance and environmental impact of multi-recycled concrete (Multi-RAC) through three recycling cycles. The results reveal a triaxial failure mode similar to natural aggregate concrete (NAC).

Plasma microRNAs as potential noninvasive biomarkers for in-stent restenosis.

Objective: To investigate whether microRNAs (miRs) can serve as novel biomarkers for in-stent restenosis (ISR).

Methods: This retrospective, observational single-centre study was conducted at the cardiovascular department of a tertiary hospital centre in the north of China. Follow-up coronary angiography at 6 to 12 months was performed in 181 consecutive patients implanted with drug-eluting stents.

[Association between beta3-adrenergic receptor and oxidative stress in chronic heart failure rats].

Objective: To investigate the association between beta(3)-adrenergic receptor (beta(3)-AR) and oxidative stress in isoproterenol (ISO)-induced chronic heart failure (HF) rats.

Methods: Seven weight-matched normal adult rats (control), 18 ISO induced heart failure rats and 21 ISO induced heart failure rats treated with specific beta(3)-AR inhibitor, SR59230A for 6 weeks were included in this study. Echocardiography was performed at the end of the study and the myocardial levels of total superoxide dismutase (T-SOD) and lipid peroxidation (LPO) were measured by colorimetry, myocardial expression of beta(3)-AR was detected by reverse transcription-polymerase chain reaction (RT-PCR).

Anti-apoptotic effects of a calpain inhibitor on cardiomyocytes in a canine rapid atrial fibrillation model.

Purpose: This study was designed to evaluate the effects of a calpain inhibitor on cardiac muscle apoptosis in rapid pacing canine atrial fibrillation (AF) models.

Methods: Twenty one dogs were divided into three groups: a sham operation group, a control AF group and a calpain inhibitor group. Sustained AF was induced by rapid right atrium pacing at 600 beats per minute.

Probucol attenuates atrial structural remodeling in prolonged pacing-induced atrial fibrillation in dogs.

Aims: Oxidative stress has recently been implicated in atrial fibrillation (AF); however, the mechanisms remain unclear. Herein, we hypothesize that probucol can attenuate atrial structure remodeling.

Methods: Twenty dogs were randomly divided into sham-operated, control, and probucol-treated groups.

Probucol attenuates atrial autonomic remodeling in a canine model of atrial fibrillation produced by prolonged atrial pacing.

Background: We hypothesize that increased atrial oxidative stress and inflammation may play an important role in atrial nerve sprouting and heterogeneous sympathetic hyperinnervation during atrial fibrillation (AF). To test the hypothesis, we examined whether the antioxidant and anti-inflammatory treatment with probucol attenuates atrial autonomic remodeling in a canine model of AF produced by prolonged rapid right atrial pacing.

Methods: Twenty-one dogs were divided into a sham-operated group, a control group and a probucol group.

Calpain I inhibition prevents atrial structural remodeling in a canine model with atrial fibrillation.

Background: Atrial fibrillation (AF) is accompanied by atrial structural remodeling. Calpain activity is induced during AF. To test a causal relationship between calpain activation and atrial structural changes, N-acetyl-Leu-Leu-Met (ALLM), a calpain inhibitor, was utilized in a canine AF model.

[Effect of calpain 1 on structural remodeling and contractile dysfunction in atrial fibrillation: experiment with dogs].

Objective: To test the causal relationship between calpain activation and atrial structural changes during atrial fibrillation (AF).

Methods: The tip of a spiral mono-polar pacing lead was fixed to the right atrial appendages of 15 dogs randomly divided into 3 equal groups: calpain inhibitor group, undergoing continuous pacing with the impulse of 600 beats/min for 3 weeks and intravenous injection of N-acetyl-Leu-Leu-Met (ALLM), a calpain inhibitor for 3 weeks; control group, undergoing continuous pacing and intravenous injection of dimethyl sulfoxide (DMSO; and sham operation group, given DMSO injection without pacing. Ultrasonography was used to observe the changes of the structures of left atrium and left atrial appendage and the heart function as well.

[Calpain I inhibition prevents pacing-induced structural remodeling for atrial fibrillation in canine].

Objective: To study the relation of the structural remodeling processes and activation of calpain I.

Methods: Fifteen dogs were randomly divided into three groups. The dogs in pacing group (n=5) and inhibitor group (n=5) were subjected to 3 weeks of rapid atrial pacing at 600 beats/min, control dogs (n=5) were in sham-operated group.

[IL-10 gene modification on immature dendritic cells induces antigen-specific tolerance in experimental autoimmune myocarditis].

Objective: To investigate whether IL-10 gene modification on immature dendritic cells (iDC) could induce autoimmune tolerance in rat experimental autoimmune myocarditis (EAM).

Methods: EAM was induced by cardiac myosin immunization on day 0 and day 7 in rats. A total of 2 x 10(6) mature DC (mDC), iDC, pcDNA3 transfected iDC, pcDNA3-IL-10 transfected iDC or PBS were injected intravenously at 5th immunization day.

[Reversal of multidrug resistance of human hepatocellular carcinoma cells by wild-type p53 gene and related mechanisms].

Background & Objective: The mechanism of cell apoptosis plays an important role in tumor multidrug resistance (MDR). Wild-type p53 (wt-p53) gene is an activator of cell apoptosis, and is closely related to tumor MDR. This study was to explore the effect of p53 gene on the reversal of MDR of human hepatocellular carcinoma (HCC) and related mechanisms.