Apigenin Reduces Lipid Droplet Accumulation in Hepatocytes by Enhancing Chaperone-Mediated Autophagy via AMPK.

Apigenin (4',5,7-trihydroxyflavone) is a significant natural flavonoid compound that is abundantly found in various fruits and vegetables. It has been demonstrated to alleviate nonalcoholic fatty liver disease and exhibit lipid-lowering effects. However, its impact on lipid droplet (LD) degradation in hepatocytes remains unclear.

Apigenin alleviated PA-induced pyroptosis by activating autophagy in hepatocytes.

Apigenin is a kind of natural flavonoid that abundantly exists in fruits and vegetables. Pyroptosis is a new, pro-inflammatory type of programmed necrosis cell death, and the NOD-like receptor family pyrin domain containing 3 (NLRP3) inflammasome is the key molecule to induce pyroptosis. Excessive hepatic pyroptosis results in liver injury.

[Municipal wastewater treatment using the up-biological aerated filter].

Up Biological Aerated Filter(UBAF) was used for the advanced wastewater treatment. The average removal rate of CODCr, BOD5, SS, NH4(+)-N and turbidity was 22.2%, 55%, 84.