Publications by authors named "Hongji You"
Purpose: Radionuclide-labeled fibroblast activation protein inhibitor (FAPI) is an emerging tumor tracer. We sought to assess the uptake and diagnostic performance of F-FAPI-42 PET/CT compared with simultaneous 2-deoxy-2[F]fluoro-D-glucose (F-FDG) PET/CT in primary and metastatic lesions in patients with malignant digestive system neoplasms and to determine the potential clinical benefit.
Procedures: Forty-two patients (men = 30, women = 12, mean age = 56.
Background: Surgical resection and liver transplantation (LT) are the most effective curative options for hepatocellular carcinoma (HCC). However, few patients with huge HCC (> 10 cm in diameter), especially those with portal vein tumor thrombus (PVTT), can receive these treatments. Selective internal radiation therapy (SIRT) can be used as a conversion therapy for them because it has the dual benefit of shrinking tumors and increasing residual hepatic volume.
View Article and Find Full Text PDFBackground: F-fluorodeoxyglucose (F-FDG) positron emission tomography (PET) is valuable in Alzheimer's disease (AD) workup.
Objective: To explore the effectiveness of F-FDG PET in differentiating and staging AD and associations between brain glucose metabolism and cognitive functions and vascular risk factors.
Methods: 107 participates including 19 mild cognitive impairment (MCI), 38 mild AD, 24 moderate AD, 15 moderate-severe AD, and 11 frontotemporal dementia (FTD) were enrolled.
Skeletal stem/progenitor cells (SSPCs) can differentiate into osteogenic or adipogenic lineage. The mechanism governing lineage allocation of SSPCs is still not completely understood. Hedgehog (Hh) signaling plays an essential role in specifying osteogenic fate of mesenchymal progenitors during embryogenesis.
View Article and Find Full Text PDFPeriprosthetic osteolysis (PPO) and subsequent aseptic loosening are major long-term complications after total joint arthroplasty and have become the first causes for further revision surgery. Since PPO is primarily caused by excessive bone resorption stimulated by released wear particles, osteoclast-targeted therapy is considered to be of great potential for PPO prevention and treatment. Accumulating evidences indicated that inhibition of histone deacetylases (HDACs) may represent a novel approach to suppress osteoclast differentiation.
View Article and Find Full Text PDFArticle Synopsis
- The study aimed to evaluate the long-term effects of Gamma Knife radiosurgery (GKRS) on large or growing asymptomatic meningiomas in 59 patients, with a median age of 56 years and follow-up of around 67 months.
- Results showed that 59.3% of tumors shrank, 39% remained stable, and only 1.7% progressed, indicating a high tumor control rate over time.
- Complications included new neurological symptoms in 15.3% of patients and peritumoral edema (PTE) in 25.4%, with tumor size and maximum dose being significant risk factors for PTE.