Modified Hepatic Arterial Infusion Chemotherapy Combined with Lenvatinib and Camrelizumab for Advanced HCC: Two Case Reports.

Background: Advanced-stage hepatocellular carcinoma (HCC), especially huge HCC or portal vein tumour thrombus (PVTT), is difficult to treat, and the prognosis is poor. The advantages of hepatic artery infusion chemotherapy (HAIC) combined with targeted therapy and immunotherapy for this complex disease are gradually becoming apparent. However, HAIC still has some inevitable disadvantages, such as arterial perfusion therapy requiring a long time, which results in many patients having difficulty completing the procedure.

Case report and literature review: PET/CT in the evaluation of response to treatment of liver metastasis from colorectal cancer with DEBIRI-TACE.

Background: Irinotecan-loaded drug-eluting beads transarterial chemoembolization (DEBIRI-TACE) is a safe and effective therapeutic option for unresectable colorectal liver metastases (CRLM). The evaluation of treatment response after DEBIRI-TACE is very important for assessing the patient's condition. At present, the Response Evaluation Criteria in Solid Tumors (RECIST) with the tumor size obtained by CT and/or MRI and PET Response Criteria in Solid Tumors (PERCIST) based on fluorodeoxyglucose-positron emission tomography/computed tomography (FDG PET/CT) are used for evaluating the response to therapy of solid tumors; however, their value in the assessment of treatment response after DEBIRI-TACE remains unclear.

Novel exosome-related risk signature as prognostic biomarkers in glioblastoma.

Exosomes are progressively being detected as an indicator for the diagnosis and prognosis of cancer in clinical settings. Many clinical trials have confirmed the impact of exosomes on tumor growth, particularly in anti-tumor immunity and immunosuppression of exosomes. Therefore, we developed a risk score based on genes found in glioblastoma-derived exosomes.

Maternal mRNA deadenylation and allocation via Rbm14 condensates facilitate vertebrate blastula development.

Early embryonic development depends on proper utilization and clearance of maternal transcriptomes. How these processes are spatiotemporally regulated remains unclear. Here we show that nuclear RNA-binding protein Rbm14 and maternal mRNAs co-phase separate into cytoplasmic condensates to facilitate vertebrate blastula-to-gastrula development.

Influences The Occurrence and Progression of Liver Cancer by Inhibiting Mitochondrial Apoptosis Pathway.

Objective: The aim of this study is to elucidate the role of in hepatocellular carcinoma using hepatoma cells.

Materials And Methods: In this experimental study, we elucidated role of , using hepatoma cell lines.

Results: was upregulated in different types of cancers, including lung adenocarcinoma, breast cancer and liver cancer reported by several studies.

Corrigendum: Antimicrobial susceptibility profiles and tentative epidemiological cutoff values of from environmental water and soil sources in China.

[This corrects the article DOI: 10.3389/fmicb.2022.

Antimicrobial susceptibility profiles and tentative epidemiological cutoff values of from environmental water and soil sources in China.

Legionnaires' disease (LD), caused by , including the most prevalent , has been treated primarily with antibiotics. Environmental water and soil are the reservoirs for . Studying antimicrobial susceptibility using a large number of isolates from various environmental sources and regions could provide an unbiased result.

Comparative Study of Application of Computed Tomography/Ultrasound and Computed Tomography Imaging Guidance Methods in the Microwave Ablation of Liver Cancer.

Purpose: The aim of the study is to assess the clinical value of the combined computed tomography (CT)/ultrasound (US) guidance in microwave ablation (MWA) for hepatocellular carcinoma (HCC).

Methods: From July 16, 2016, to June 20, 2021, medical records of 150 HCC patients treated with MWA were retrospectively analyzed. Ninety-two patients with 115 liver tumors underwent MWA under combined CT/US guidance, and 58 patients with 73 liver tumors received MWA under CT guidance alone.

The transcription factor ZmMYB69 represses lignin biosynthesis by activating ZmMYB31/42 expression in maize.

A MYB family transcription factor ZmMYB69 is a transcriptional activator at the upper level of ZmMYB31 and ZmMYB42 in the hierarchical network that controls lignin biosynthesis in maize.

Presence of Viable, Clinically Relevant Bacteria in Environmental Water and Soil Sources of China.

The distribution of pathogenic in the environmental soil and water of China has not been documented yet. In this study, was detected in 129 of 575 water (22.43%) and 41 of 442 soil samples (9.

Toll-like receptor 10 expression in B cells is negatively correlated with the progression of primary Sjögren's disease.

Primary Sjögren's Disease (pSjD) is considered a B cell-mediated disease. Toll-like receptor 10 (TLR10) is highly expressed in human B cells, indicating that TLR10 probably plays a vital role in pSjD. We examined TLR10 expression in peripheral B subsets of pSjD patients and analyzed their association with disease activity.

Immune Cell Infiltration and Relevant Gene Signatures in the Tumor Microenvironment that Significantly Associates With the Prognosis of Patients With Breast Cancer.

Breast cancer is the most common malignancy and the leading cause of cancer-related deaths in women. Recent studies have investigated the prognostic value of the tumor microenvironment (TME)-related genes in breast cancer. The purpose of this research is to identify the immune-associated prognostic signature for breast cancer evaluate the probability of their prognostic value and compare the current staging system.

Aberrantly expressed Wnt5a in nurse-like cells drives resistance to Venetoclax in chronic lymphocytic leukemia.

Chronic lymphocytic leukemia (CLL) is characterized by the accumulation of neoplastic B lymphocytes with high levels of Wnt5a in the plasma. Currently, the cell source of Wnt5a remains controversial. The receptor of Wnt5a is ROR1, whose expression is associated with disease progression and resistance to venetoclax, a BCL-2 inhibitor approved for the treatment of CLL.

PIAS3/SOCS1-STAT3 axis responses to oxidative stress in hepatocellular cancer cells.

The participation of STAT3 and its upstream inhibitors, PIAS3 and SOCS1, in the oxidative response of hepatocellular carcinoma (HCC) cells was uncertain. Here, the expression of PIAS3 and SOCS1 in HCC tissues and cell lines was explored, and we sought to determine whether oxidative stress epigenetically regulated PIAS3 and SOCS1 expression and STAT3 activation in HCC cells. The expression of PIAS3 and SOCS1 was markedly decreased in HCC cell lines and tissues compared to normal hepatic cells and tissues.

Nde1 is a Rab9 effector for loading late endosomes to cytoplasmic dynein motor complex.

Rab9 is mainly located on late endosomes and required for their intracellular transport to trans-Golgi network (TGN). The cytoplasmic dynein motor, together with its regulatory proteins Nde1/Ndel1 and Lis1, controls intracellular retrograde transport of membranous organelles along the microtubule network. How late endosomes are tethered to the microtubule-based motor dynein for their retrograde transport remains unclear.

Virulence effector SidJ evolution in is driven by positive selection and intragenic recombination.

Effector proteins translocated by the Dot/Icm type IV secretion system determine the virulence of (). Among these effectors, members of the SidE family (SidEs) regulate several cellular processes through a unique phosphoribosyl ubiquitination mechanism mediated by another effector, SidJ. Host-cell calmodulin (CaM) activates SidJ to glutamylate the SidEs of ubiquitin (Ub) ligases and to make a balanced Ub ligase activity.

Phase separation of EML4-ALK in firing downstream signaling and promoting lung tumorigenesis.

EML4-ALK fusion, observed in about 3%-7% of human lung adenocarcinoma, is one of the most important oncogenic drivers in initiating lung tumorigenesis. However, it still remains largely unknown about how EML4-ALK fusion exactly fires downstream signaling and drives lung cancer formation. We here find that EML4-ALK variant 1 (exon 1-13 of EML4 fused to exon 20-29 of ALK) forms condensates via phase separation in the cytoplasm of various human cancer cell lines.

Development of a highly sensitive method for detection of FLT3D835Y.

Background: Acute myeloid leukemia (AML) is a malignant hematological neoplasm of myeloid progenitor cells. Mutations of FLT3 in its tyrosine kinase domain (FLT3-TKD) are found in ~ 8% of patients with AML, with D835Y as the most common substitution. This mutation activates survival signals that drives the disease and is resistant to the first generation FLT3 inhibitors.

Highly improved soot combustion performance over synergetic MnCeO solid solutions within mesoporous nanosheets.

Constructing synergetic bimetal oxide solid solutions with exceptional catalytic performances for efficient soot elimination is becoming a research frontier in environmental catalysis. Herein, synergetic MnCeO solid solutions within mesoporous nanosheets, synthesized by a facile hydrothermal method for the first time, have been performed to catalyze the NO-assisted soot combustion. Research results validate that MnCeO solid solutions displayed highly improved soot combustion performance with respect to activity and selectivity, mainly due to the synergetic effect by combining factors of the unique mesoporous nanosheet-shaped feature, the enhanced chemical nature stemmed from high-valence Mn species, abundant active oxygen species originated from the enriched oxygen vacancies and the escalated redox properties.

SQUAMOSA Promoter Binding Protein-Like (SPL) Gene Family: TRANSCRIPTOME-Wide Identification, Phylogenetic Relationship, Expression Patterns and Network Interaction Analysis in Panax ginseng C. A. Meyer.

( promoter binding protein-like) gene family is specific transcription factor in the plant that have an important function for plant growth and development. Although the gene family has been widely studied and reported in many various plant species from gymnosperm to angiosperm, there are no systematic studies and reports about the gene family in C. A.

Phylogenetic relationship and characterization of the complete chloroplast genome of , the endemic medicinal herbs to China.

is the most important valued and endemic medicinal herb to China. It belongs to the Araliaceae family, which has a longer medical history in China. The complete chloroplast genome of is 156,387 bp in size and displays a typical quadripartite structure of the large single-copy region (LSC, 86,112 bp), small single-copy region (SSC, 18,005 bp) that separate by a pair of inverted repeat regions (IRs, each for 26,135 bp).

Astragaloside attenuates lipopolysaccharide-induced cell apoptosis in human gingiva cells via MAPK signaling pathway.

Subjects: The aim of this study was to research the antiapoptotic effect of astragaloside, the principal component of Astragalus membranaceus (Fisch) Bge, in human gingiva cells induced by lipopolysaccharide (LPS).

Methods: According to the treatment, human gingiva cells were divided into five groups, including (1) control group without drug treatment; (2) imitating group, treated with LPS (10 μg·mL ) alone; (3) low group, treated with LPS and 50 μmol·L astragaloside; (4) medium group, treated with LPS and 100 μmol·L astragaloside; and (5) high group, treated with LPS and 150 μmol·L astragaloside. Cell proliferation and apoptosis were investigated using MTT assay and flow cytometry, respectively.

Geraniol and lupeol inhibit growth and promote apoptosis in human hepatocarcinoma cells through the MAPK signaling pathway.

Objectives: Hepatocarcinoma is one of the most lethal cancers, leading to a 5-year survival rate as low as 30% due to recurrence and metastasis. The treatment of liver cancer includes surgery and medication, of which, the former is more effective. However, surgical resection is applicable in less than 40% of patients.

Long non-coding RNA activated by TGF-β expression in cancer prognosis: A meta-analysis.

Background: Recently, long non-coding RNA activated by transforming growth factor beta (TGF-β) (lncRNA ATB) was shown to be useful in cancer prognosis, however, its prognostic value in human cancer has been inconsistent. Our study aimed to explore the prognostic role of lncRNA ATB expression in cancer prognosis.

Methods: PubMed, Embase, and Cochrane Library databases were thoroughly searched to retrieve studies focusing on the prognostic role of lncRNA ATB expression in cancer, and meta-analysis was performed.