Upadacitinib sustained-release tablets for the treatment of chronic refractory gouty arthritis: a case report and literature review.

Background: Gouty arthritis (GA) is a crystal-related joint disease caused by the deposition of monosodium urate (MSU) crystals, directly associated with hyperuricemia resulting from purine metabolism disorder and/or reduced uric acid excretion. Acute attacks of typical gouty arthritis are generally relieved through the clinical use of NSAIDs, colchicine, or glucocorticoids. However, managing patients with chronic refractory gout poses challenges due to complications such as multiple tophi, gouty nephropathy, diabetes, and gastrointestinal bleeding.

Rituximab as maintenance therapy following remission induction in relapsing or refractory systemic lupus erythematosus.

Objective: To investigate the efficacy and safety of rituximab (RTX) maintenance therapy compared with traditional immunosuppressive agent (ISA) maintenance therapy in patients with relapsing or refractory SLE.

Methods: It is a prospective observational non-randomized cohort study. The study enrolled SLE patients in four centres who had received at least one course of RTX induction treatment.

Comparison of two positions of knee arthrocentesis: how to obtain complete drainage.

Objective: Many studies have focused on the accuracy rate of intraarticular injection. However, sometimes, even when the needle enters the joint cavity accurately, it can be difficult to obtain a sufficient amount of joint fluid. This problem may be attributable to the position of the knee during arthrocentesis.