Publications by authors named "Honghua Lu"

Article Synopsis
  • The study assessed the effectiveness and safety of PEGylated-recombinant human growth hormone (PEG-rhGH) in children born small for gestational age (SGA).
  • Conducted in China, 96 SGA children were randomized to receive either a low dose (0.1 mg/kg/week) or high dose (0.2 mg/kg/week) of PEG-rhGH over 52 weeks.
  • Results showed significant improvements in height and growth velocity for those on the high dose compared to the low dose, with both treatments being well tolerated.
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The objective of this study was to investigate the rumen degradation characteristics of grain amaranth hay (Amaranthus hypochondriacus) at four different growth stages. The aim of this study was to evaluate the nutritional value of grain amaranth hay at different growth stages by chemical composition, in vivo digestibility, and in situ degradability. Three Boer goats with permanent ruminal fistulas were selected in this study.

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Objective: To explore the effect of evidence-based nursing combined with exercise rehabilitation on cardiac function indices, self-care ability and incidence of adverse reactions in patients with acute myocardial infarction (AMI) after percutaneous coronary intervention (PCI).

Methods: In this retrospective study, the medical records of 200 AMI patients undergoing PCI in Ganzhou People's Hospital from June 2020 to September 2021 were retrospectively analyzed, and the patients were divided into a control group (n=100) and a study group (n=100) according to the nursing methods after PCI. The cardiac function index, 6-minute walking distance (6MWD), behavioral self-management, physiological index, angina questionnaire and postoperative complications were compared between the two groups.

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Objective: To evaluate the safety and efficacy of weekly PEGylated-recombinant human growth hormone (PEG-rhGH) in children with idiopathic short stature (ISS) in China.

Design And Methods: This was a multicenter, phase II study in which all subjects were randomized 1:1:1 to weekly s.c.

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Human kidney cell injury is a representative characteristic of diabetic nephropathy (DN), and its development has been shown to be associated with the dysregulation of some circular RNAs (circRNAs). We thus explored the role of circ_0008529 in DN-conditioned human kidney cell injury. Human kidney cells (HK-2) were treated with high glucose (HG) to construct DN models in vitro.

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Background: Acute kidney injury (AKI) is a frequent and serious complication in patients with primary nephrotic syndrome (PNS). We aimed to evaluate the influencing factors of AKI in patients with PNS, to provide implications for the clinical management and nursing care of patients with PNS.

Methods: PNS patients who were treated in the Department of Nephrology in our hospital from January 1, 2020 to July 31, 2021 were included.

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Objective: To explore the clinical features and genetic basis for a Chinese pedigree diagnosed with congenital glycosylation disease (CGD).

Methods: Clinical manifestations of two brothers were analyzed. Whole exome sequencing was carried out for the sib pair.

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Following the publication of this paper, the authors alerted the Editorial Office to the fact that a reader had informed them that miR‑152 overexpression did not affect cell apoptosis and cell cycle. The authors subsequently confirmed that they were unable to obtain consistent results from these experiments.Furthermore, an independent investigation of this paper revealed that the cell apoptotic data shown in Fig.

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Objective: The purposes of this study were to explore the effect of obstructive sleep apnea-hypopnea syndrome (OSAHS) on the voice by analyzing the acoustic parameters between patients with OSAHS and those without OSAHS and to compare acoustic analyses performed by two software programs (MDVP and Praat).

Methods: Patients with OSAHS (n = 75) and normal controls (n = 46) were asked to produce a sustained sound of the vowel /i/ and were analyzed with electroglottography (EGG), MDVP, and Praat software. A self-rated scale (Voice Handicap Index, VHI-10) and acoustic parameters were compared.

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Purpose: Using the Reflux Symptom Index (RSI), this nationwide study aimed to investigate the incidence, diagnostic status, risk factors, and common symptoms of adult laryngopharyngeal reflux disease (LPRD) at otorhinolaryngology-head and neck surgery (OHNS) clinics in China.

Methods: This multicenter cross-sectional survey began at the different institutions ranged from July to October 2017, and the duration was 12 months. A total of 90,440 eligible patients were finally enrolled from 72 medical institutions in China.

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miR‑152 has been reported to be downregulated in rheumatoid arthritis (RA). However, the functional significance and molecular mechanisms underlying the role of miR‑152 in RA remain largely unknown. The present study aimed to explore the functional role and the underlying mechanisms of miR‑152 in RA.

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Background: Glioblastoma multiforme (GBM) is the most common malignant and lethal type of primary central nervous system tumor in humans. In spite of its high lethality, a small percentage of patients have a relatively good prognosis, with median survival times of 36 months or longer. The identification of clinical subsets of GBM associated with distinct molecular genetic profiles has made it possible to design therapies tailored to treat individual patients.

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Interleukin-23 (IL-23), a member of the IL-12 family of cytokines, is a heterodimeric cytokine. It is composed of subunits p40 (shared with IL-12) and p19 (an IL-12 p35-related subunit) and is secreted by several types of immune cells, such as natural killer cells and dendritic cells. The IL-23 receptor is composed of the subunit IL-12Rβ1 and the IL-23-specific subunit IL-23R.

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Objective: To explore the personality and character of obstructive sleep apnea hypopnea syndrome (OSAHS) patients.

Methods: Subjects, recruited from May 2013 to February 2014, were assigned to the severe OSAHS group (56 cases), mild-moderate OSAHS group (59 cases), and control group (42 cases) on the basis of apnea hyponea index (AHI). Subjects were assigned to the severe hypoxemia group (24 cases), mild-moderate hypoxemia group (91 cases) on the basis of PaO2.

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Objective: The aim of this study was to evaluate the effects of obstructive sleep apnea-hypopnea syndrome (OSAHS) on semicircular canal function.

Methods: By means of a series prospective study at Department of Otolaryngology Head and Neck Surgery of our hospital, the study was performed on 77 patients suffering from OSAHS in a period from 2012 to 2014, who underwent polysomnography (PSG) and caloric test. The maximal slow-phase velocity (SPV) and unilateral weakness (UW) were used to measure the vestibular function.

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Purpose: Vasculogenic mimicry (VM) was related to invasion and metastasis of head and neck squamous cell carcinoma (HNSCC) patients. This study was designed to investigate the role of EphA2 in VM formation of HNSCC.

Methods: The SiRNA technique was used to knock down the expression of EphA2 in vitro.

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The rapid industrial development in the Yangtze River watershed over the last several decades has drawn great attention with respect to heavy metal pollution to the Yangtze River estuary and nearby coastal areas. In this study, a 236 cm long sediment core was retrieved from the Yangtze River subaqueous delta (122°36' E, 31°00' N) in 2008 and analyzed for magnetic properties and geochemical compositions to investigate heavy metal pollution history. The activity of (137)Cs peaked at depth 140 cm, with a broad plateau between 120 cm and 140 cm, suggesting an average sedimentation rate of 3.

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Article Synopsis
  • * Analysis of 168 LSCC cases revealed that VM is linked to higher rates of lymph node metastasis and worse clinical outcomes.
  • * VM serves as an independent adverse prognostic factor, indicating that LSCC with VM has a greater likelihood of invasion and negatively affects disease-specific survival.
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Objective: To investigate the contribution of vasculogenic mimicry (VM) and endothelium-dependent vessel (EDV) to invasion and metastasis of laryngeal squamous cell carcinoma (LSCC).

Methods: A total of 203 cases with LSCC was reviewed and followed up. VM and EDV in LSCC tissues were assessed by double staining with anti-CD31 immunohistochemistry and periodic acid-schiff.

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[Catathrenia: a case report].

Zhonghua Er Bi Yan Hou Tou Jing Wai Ke Za Zhi

September 2011

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Objective: To analyze the characteristics of subjective visual horizontal (SVH) and evaluate its clinical value for vestibular function in peripheral unilateral vestibular hypofunction (UVH).

Methods: Eighty-five patients with UVH (study group) and 39 normal persons (control group) accepted vestibular function tests, including SVH, subjective visual vertical (SVV) and caloric test by video-nystagmography. The parameters of the angle of SVH and SVV, directional preponderance (DP) and unilateral weakness (UW) of caloric test were observed.

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Objective: To analyze the value of directional preponderance (DP) in vestibular dynamic compensation evaluation.

Methods: One hundred fifty-five patients with sudden deafness accompanied vertigo were asked to accept routine vestibular tests including the spontaneous nystagmus (SN) and caloric test with video-nystagmography. DP, SN and unilateral weakness (UW) were selected as the observation parameters.

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Objective: To explore the oncologic efficacy of transoral endoscopic CO2 laser surgery in early glottic carcinoma.

Method: Retrospectively study 91 patients with glottic carcinoma (9 Tis, 45 pT1a, 25 pT1b, 12 pT2) treated in our department from October 1999 to August 2004. Surgical treatment included endoscopic CO2 laser cordectomies according to the classification of the European Laryngological Society in 2000.

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Objective: To explore the diagnostic values of vestibular autorotation test (VAT) for patients with vertebrobasilar insufficiency (VBI).

Methods: VAT and videonystagmography ( VNG) were performed on 73 patients with VBI and 48 patients with peripheral vestibular lesions (contrast group). Parameters analyzed included Gain, phase and asymmetry of VAT, as well as the canal paresis (CP) of caloric test and results of optokinetic-pursuit tests in VNG.

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