Publications by authors named "Honghu Ai"
Article Synopsis
- - Lead is a harmful environmental pollutant that can accumulate in the kidneys and cause damage, and the effects of Sparassis latifolia polysaccharide (SLP) on lipid metabolism abnormalities due to lead exposure are not well understood.
- - This study used mice to investigate kidney damage and changes caused by lead, examining key signaling pathways through lipidomics and transcriptomics to identify affected metabolites and genes linked to oxidative stress, inflammation, and autophagy.
- - Results showed that SLP treatment regulated abnormal lipid metabolism in the kidneys primarily by reducing oxidative stress and its related impacts on autophagy and inflammation, suggesting potential for SLP as a therapeutic intervention for lead-induced kidney injury.
Essential oil from Artemisia argyi alleviated liver disease in zebrafish (Danio rerio) via the gut-liver axis.
Fish Shellfish Immunol
September 2023
Article Synopsis
- The study investigates the effects of Artemisia argyi (A. argyi) essential oils on fish liver diseases associated with intensive fish farming, specifically focusing on hepatobiliary syndrome.
- Using adult zebrafish as a model, researchers found that A. argyi treatment reduced liver damage caused by ethanol, improved antioxidant levels, and altered the expression of inflammatory cytokines through the PPAR-γ/NF-κB pathway.
- Additionally, A. argyi essential oil significantly modified the gut microbiota composition and enhanced protective intestinal tissue markers, suggesting its potential as a therapeutic agent for liver health in fish.