Clinical features and risk factors for Sjogren's syndrome patients suffering from oral candidiasis in Shanxi, China.

Objectives: To investigate the clinical features and risk factors of Sjogren's Syndrome (SS) patients suffering from oral candidiasis and to provide a foundation for the prevention and treatment of oral candidiasis in SS patients.

Methods: The medical records of 479 SS patients admitted to the Second Hospital of Shanxi Medical University from 2018 to 2020 were analysed to determine the clinical characteristics and risk factors that influence the occurrence of oral candidiasis infection in SS patients.

Results: Patients with oral candidiasis were older than those without oral candidiasis (P < 0.

Mitochondrial oxidative damage reprograms lipid metabolism of renal tubular epithelial cells in the diabetic kidney.

The functional and structural changes in the proximal tubule play an important role in the occurrence and development of diabetic kidney disease (DKD). Diabetes-induced metabolic changes, including lipid metabolism reprogramming, are reported to lead to changes in the state of tubular epithelial cells (TECs), and among all the disturbances in metabolism, mitochondria serve as central regulators. Mitochondrial dysfunction, accompanied by increased production of mitochondrial reactive oxygen species (mtROS), is considered one of the primary factors causing diabetic tubular injury.

CD36 deletion ameliorates diabetic kidney disease by restoring fatty acid oxidation and improving mitochondrial function.

Renal tubular epithelial cells (TECs) are vulnerable to mitochondrial dysregulation, which is an integral part of diabetic kidney disease (DKD). We found that CD36 knockout ameliorated mitochondrial dysfunction and diabetic kidney injury in mice, improved renal function, glomerular hypertrophy, tubular injury, tubulointerstitial fibrosis, and kidney cell apoptosis. Furthermore, CD36 knockout conferred protection against diabetes-induced mitochondrial dysfunction and restored renal tubular cells and mitochondrial morphology.

Berberine ameliorates renal interstitial inflammation and fibrosis in mice with unilateral ureteral obstruction.

Berberine acts via multiple pathways to alleviate fibrosis in various tissues and shows renoprotective effects. However, its role and underlying mechanisms in renal fibrosis remain unclear. Herein, we aimed to investigate the protective effects and molecular mechanisms of berberine against unilateral ureteric obstruction-induced renal fibrosis.

Dynamic Evolution of Palladium Single Atoms on Anatase Titania Support Determines the Reverse Water-Gas Shift Activity.

Research interest in single-atom catalysts (SACs) has been continuously increasing. However, the lack of understanding of the dynamic behaviors of SACs during applications hinders catalyst development and mechanistic understanding. Herein, we report on the evolution of active sites over Pd/TiO-anatase SAC (Pd/TiO) in the reverse water-gas shift (rWGS) reaction.

Selective ozone activation of phenanthrene in liquid CO.

We demonstrate liquid CO (8 °C, 4.4 MPa) as a benign medium to perform safe ozonolysis of phenanthrene at near-ambient temperatures. The ozonolysis products consist of several monomeric oxidation products such as diphenaldehyde, diphenic acid and phenanthrenequinone as well as polymeric structures up to 1130 Da.

Effects of oral alkali drug therapy on clinical outcomes in pre-dialysis chronic kidney disease patients: a systematic review and meta-analysis.

Background: Metabolic acidosis accelerates the progression of chronic kidney disease (CKD) and increases the mortality rate. Whether oral alkali drug therapy benefits pre-dialysis CKD patients is controversial. We performed a meta-analysis of the effects of oral alkali drug therapy on major clinical outcomes in pre-dialysis CKD patients.

Mechanism of action of for treatment of idiopathic membranous nephropathy based on network pharmacology.

Background: Although thunder god vine () has been widely used for treatment of idiopathic membranous nephropathy (IMN), the pharmacological mechanisms underlying its effects are still unclear. This study investigated potential therapeutic targets and the pharmacological mechanism of for the treatment of IMN based on network pharmacology.

Methods: Active components of were obtained from the Traditional Chinese Medicine Systems Pharmacology Database and Analysis Platform.

Effect of a low-salt diet on chronic kidney disease outcomes: a systematic review and meta-analysis.

Objective: The benefits of a low-salt diet for patients with chronic kidney disease (CKD) are controversial. We conducted a systematic review and meta-analysis of the effect of a low-salt diet on major clinical outcomes.

Design: Systematic review and meta-analysis.

Performance assessment of extensive green roof runoff flow and quality control capacity based on pilot experiments.

Green roof is an important measure in "Sponge Cities" to reduce the runoff and improve the runoff quality. The runoff quantity and quality control capacity of five types of extensive green roofs (EGRs) were analyzed in Beijing for 51 nature rainfall events and 6 simulated events from July 2017 to October 2018. Different module scales (sizes) and substrate depths were examined to study their correlation to runoff retention, peak flow reduction, pollutant event mean concentration (EMC) and load reduction performance of EGRs.

Characterization, thermochemical conversion studies, and heating value modeling of municipal solid waste.

A study was carried out to examine the characteristics of municipal solid waste (MSW) from the City of Red Deer, Alberta, Canada. Experiments were performed for determining the moisture content, proximate and ultimate compositions, heating value of fourteen wastes in different categories. Their thermal weight loss behaviors under pyrolysis/torrefaction conditions were also investigated in a thermogravimetric analyzer (TGA).