PPIC-labeled CAFs: Key players in neoadjuvant chemotherapy resistance for gastric cancer.

Background: Gastric cancer (GC) is the fourth leading cause of cancer deaths, with advanced cases having a median survival of less than one year. Neoadjuvant chemotherapy (NCT) is vital but faces drug resistance issues, partly due to cancer-associated fibroblasts (CAFs). Yet, specific CAF subpopulations contributing to resistance are poorly understood.

An Integrated Pan-Cancer Analysis of 33 Human Cancers Reveals the Potential Clinical Implications and Immunotherapeutic Value of C-X-C Motif Chemokine Ligand 13.

Background: C-X-C Motif Chemokine Ligand 13 (CXCL13) plays a crucial part in the pathogenesis of numerous lymphoproliferative disorders, inflammatory responses, and autoimmune diseases. CXCL13 also influence tumor development and prognosis, and be a potential target for cancer treatment. However, CXCL13 expression-based panoramic picture in pan-cancer remain unclear.

The Involvement of TRIB3 and FABP1 and Their Potential Functions in the Dynamic Process of Gastric Cancer.

Dysregulated expression of TRIB3 and FABP1 have been previously observed in human cancer tissues. However, there are little information as to their expression change in dynamic gastric diseases and the functional roles. Tissues from a total of 479 patients, including 89 GS, 102 IM-GA, 144 EGC, and 144 AGC were collected.

Interleukin 20 receptor A expression in colorectal cancer and its clinical significance.

Background: Interleukin 20 receptor A (IL20RA) has been shown to play a role in the establishment and progression of multiple tumors. However, the expression of this protein in colorectal cancer (CRC) and its correlation with the clinicopathological parameters of CRC have remained unclear.

Methods: A total of 323 paraffin sections including CRC tissues and adjacent normal tissues after surgery were collected.

A Dynamic Transcriptome Map of Different Tissue Microenvironment Cells Identified During Gastric Cancer Development Using Single-Cell RNA Sequencing.

Gastric cancer (GC) development trends have identified multiple processes ranging from inflammation to carcinogenesis, however, key pathogenic mechanisms remain unclear. Tissue microenvironment (TME) cells are critical for the progression of malignant tumors. Here, we generated a dynamic transcriptome map of various TME cells during multi-disease stages using single-cell sequencing analysis.

Differentially Expressed mRNAs and Their Long Noncoding RNA Regulatory Network with -Associated Diseases including Atrophic Gastritis and Gastric Cancer.

Background: () infection is the strongest risk factor for gastric cancer (GC). However, the mechanisms of -associated GC remain to be explored.

Methods: The gene expression profiling (GSE111762) data were downloaded from the GEO database.

Identification of DEGs and transcription factors involved in -associated inflammation and their relevance with gastric cancer.

Background: Previous studies have indicated that chronic inflammation linked to infection is the leading causes for gastric cancer (GC). However, the exact mechanism is not entirely clear until now.

Purpose: To identify the key molecules and TFs involved in infection and to provide new insights into -associated carcinogenesis and lay the groundwork for the prevention of GC.

Localization Driven Superradiant Instability.

The prominent Dicke superradiant phase arises from coupling an ensemble of atoms to a cavity optical field when an external optical pumping exceeds a threshold strength. Here we report a prediction of the superradiant instability driven by Anderson localization, realized with a hybrid system of the Dicke and Aubry-André (DAA) model for bosons trapped in a one-dimensional (1D) quasiperiodic optical lattice and coupled to a cavity. Our central finding is that for bosons condensed in a localized phase given by the DAA model, the resonant superradiant scattering is induced, for which the critical optical pumping of the superradiant phase transition approaches zero, giving an instability driven by the Anderson localization.