Asiaticoside delays senescence and attenuate generation of ROS in UV‑exposure cells through regulates TGF‑β1/Smad pathway.

Asiaticoside, isolated from , shows great improvement on wound healing and anti-oxidation function and . From previous research, asiaticoside possesses the potential capability to delay skin aging and reduce wrinkles clinically, but its underlying mechanism to regulate aging have not well-investigated. The present study found that asiaticoside could improve the viability and maintains a normal morphology in ultraviolet (UV)-exposure cells.

Transcriptome Analysis Reveals the Resistance Mechanism of to Tachyplesin I.

Background: Tachyplesin I is a cationic antimicrobial peptide with a typical cyclic antiparallel β-sheet structure. We previously demonstrated that long-term continuous exposure to increased concentration of tachyplesin I can induce resistant Gram-negative bacteria. However, no significant information is available about the resistance mechanism of () to tachyplesin I.

Transdermal delivery of water-soluble fluorescent antibody mediated by fractional Er:YAG laser for the diagnosis of lupus erythematosus in mice.

Objectives: Although transdermal drug delivery system (TDDS) has been successfully used for delivering small molecules, its application in the delivery of diagnostic antibodies has been limited due to their large size. In this study, we aim to obtain a broad insight in the dynamics of TRITC-conjugated Goat Anti-Mouse IgG (T-IgG) uptake in fractional Er:YAG laser pretreated skin and provide a new technical option for detecting lupus erythematosus (LE) in mice.

Methods: The skins of SD and MRL/lpr mice were treated by fractional Er:YAG laser followed by external application of T-IgG.

Green emitting N,S-co-doped carbon dots for sensitive fluorometric determination of Fe(III) and Ag(I) ions, and as a solvatochromic probe.

N,S-co-doped carbon dots (N,S-CDs) were synthesized via a single-step solvothermal process by using sodium lignosulfonate and p-phenylenediamine as carbon/nitrogen/sulfur sources. The N,S-CDs have an average diameter of 2.02 ± 1 nm and display green fluorescence, with excitation/emission peak wavelengths at 380/540 nm for optimal fluorescence.

Clinical features and prognostic factors of thrombotic thrombocytopenic purpura associated with systemic lupus erythematosus: a literature review of 105 cases from 1999 to 2011.

This study aims to review clinical features, treatments, and prognostic factors of thrombotic thrombocytopenic purpura (TTP) associated with systemic lupus erythematosus patients (sTTP). The case reports of sTTP published in world literature from 1999 to 2011 were collected, and 105 cases were divided into death group and survival group. The epidemiologic characteristics, clinical manifestations, laboratory examinations, treatments, and prognostic factors were analyzed.