Development and validation of a risk score model for patient stratification and personalized management of papillary thyroid cancer.

Background: The status of central lymph node (CLN) is a crucial determinant for the initial treatment of papillary thyroid cancer (PTC), but preoperative ultrasound (US) has limited ability to accurately assess their condition. This study aimed to develop a risk score model for risk stratification of CLN metastasis in unifocal PTC patients to guide the initial treatment.

Methods: A total of 5,374 patients diagnosed with unifocal PTC at Union Hospital between November 2009 and August 2022 were finally enrolled in the analysis, including 3,542 patients in derivation cohort and 1,832 patients in validation cohort.

Predictive value of diaphragmatic thickness fraction and integrated pulmonary index on extubation outcome in patients with severe acute pancreatitis.

Objective: This study was performed to explore the predictive value of the diaphragmatic thickness fraction (DTF) combined with the integrated pulmonary index (IPI) for the extubation outcome in patients with severe acute pancreatitis (SAP).

Methods: This prospective study involved 93 patients diagnosed with SAP and treated with mechanical ventilation in our hospital from October 2020 to September 2023. The patients were divided into a successful extubation group (61 patients) and an extubation failure group (32 patients) based on the extubation outcomes.

Identification of a Novel Germline Missense Mutation Asp409Asn on Familial Non-Medullary Thyroid Carcinoma.

Familial non-medullary thyroid carcinoma (FNMTC) accounts for 3% to 9% of all thyroid cancer cases, yet its genetic mechanisms remain unknown. Our study aimed to screen and identify novel susceptibility genes for FNMTC. Whole-exome sequencing (WES) was conducted on a confirmed FNMTC pedigree, comprising four affected individuals across two generations.

A Phase-Field Study of Spinodal Decomposition Impeded by Irradiation in U-Mo and U-Mo-Zr Alloys.

The phase-field method, coupled with the micro-elastic model and irradiation-induced cascade mixing model, has been employed to investigate the spinodal decomposition in U-Mo and U-Mo-Zr alloys. The microstructure evolution of U-Mo or U-Mo-Zr alloys under different initial conditions, such as the alloy composition, aging temperature and irradiation intensity, were simulated to study the effect of cascade mixing on the miscibility gap, morphology and volume fraction of the decomposed phases. The simulation results demonstrate that irradiation-induced cascade mixing impedes the process of spinodal decomposition, and that irradiation shrinks the composition range of the miscibility gap in the alloys.

Radioactive iodine therapy strategies for distinct types of differentiated thyroid cancer: a propensity score-matched analysis.

Background: The management guidelines of radioactive Iodine (RAI) therapy for distinct types of differentiated thyroid carcinoma (DTC) were the same in clinical practice. However, in distinct types DTC, differences in RAI avidity and response existed and the effect of RAI therapy could not be equated.

Methods: DTC patients' data in SEER database were extracted to perform retrospective analysis.

Effect of irradiation-induced cascade mixing on spinodal decomposition in U-Nb and U-Zr alloys: a phase field study.

The spinodal decomposition of the γ-phase in U-Nb and U-Zr alloys under irradiation was investigated using the phase-field method coupled with micro-elasticity theory and rate dependent cascade mixing model. Microstructure evolutions of spinodal decomposition in U-Nb and U-Zr alloys were simulated by considering different initial compositions and dose rates. The volume fraction and composition distribution under different cascade mixing were presented.