Identification of Key Genes and Pathways for Enchondromas by Bioinformatics Analysis.

Background: The risk of malignant transformation of enchondromas (EC) toward central chondrosarcoma is increased up to 35%, while the exact etiology of EC is unknown. The purpose of this research was to authenticate gene signatures during EC and reveal their potential mechanisms in occurrence and development of EC.

Methods: The gene expression profiles was acquired from Gene Expression Omnibus database (no.

Hub genes and gene functions associated with postmenopausal osteoporosis predicted by an integrated method.

Postmenopausal osteoporosis (PO) imposes great burden on individuals and society. This study predicted hub genes and gene functions for PO by an integration of the convergent evidence (CE) method, rank product (RP) algorithm and the combing of P-values. Using the gene expression data, genes were ranked by the CE method, RP algorithm and combing P-values, respectively.

[Analysis of the parameters about selective anterior fusion of thoracolumbar/lumbar curves in adolescent idiopathic scoliosis].

Objective: To establish criteria for AIS of Lenke5 and Lenke6 by an anterior only procedure of the lower curve fusion.

Methods: A retrospective study was conducted between March 1999 and May 2004 to investigate 52 AIS patients of Lenke5 and Lenke6. All the patients were observed 24 years (34 months on average).