Publications by authors named "Honggang Yin"

Article Synopsis
  • * Whole exome sequencing and other analyses revealed important genetic variants: bi-allelic variants in MOCS1 linked to molybdenum cofactor deficiency, and a KCNQ2 variant associated with seizures.
  • * The research demonstrated that whole exome sequencing can effectively diagnose the genetic causes of neonatal seizures, contributing to our understanding of related phenotypes, especially with sodium channel gene duplications.
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  • * This study investigates a Chinese couple whose first pregnancy was affected by microcephaly and fetal growth restriction (FGR), revealing significant genetic variants in the SASS6 gene in their fetus through whole-exome sequencing.
  • * The research uncovers new insights into the link between FGR and SASS6-related microcephaly, highlighting SASS6's crucial role in the condition's development and expanding the known mutation spectrum associated with it.
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Our previous study revealed moderate-intensity exercise improved endothelial function associated with decreasing Romboutsia in rats on a high-fat diet. However, whether Romboutsia influences endothelial function remains unclear. The aim of this study was to determine the effects of Romboutsia lituseburensis JCM1404 on the vascular endothelium of rats under standard diet (SD) or high-fat diet (HFD).

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Background: Obesity changes gut microbial ecology and is related to endothelial dysfunction. Although the correlation between gut microbial ecology and endothelial dysfunction has been studied in obese persons, the underlying mechanisms by which exercise enhances endothelial function in this group remain unclear. This study investigated whether exercise improves endothelial function and alters gut microbiome composition in rats fed a high-fat diet (HFD).

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The gene encodes sphingomyelin phosphodiesterase 4, which preferentially hydrolyzes sphingomyelin over other phospholipids. The biallelic loss-of-function variants of have been identified in a group of children with neurodevelopmental disorder with microcephaly, arthrogryposis, and structural brain anomalies (NEDMABA). Here, we report a girl of Chinese ancestry with intrauterine growth restriction, microcephaly, postnatal developmental delay, arthrogryposis, hypertonicity, seizure, and hypomyelination on brain magnetic resonance imaging; biallelic null variants (c.

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Purpose: Obesity in children and in adolescents can lead to adult cardiovascular diseases, and the gut microbiota plays a crucial role in obesity pathophysiology. Exercise and diet interventions are typical approaches to improve physical condition and to alter the gut microbiota in individuals with obesity. However, whether central hemodynamic parameters including subendocardial viability ratio, the augmentation index standardized to a heart rate of 75/min (AIx75), resting heart rate, and blood pressure, correlate with gut microbiota changes associated with exercise and diet is unclear.

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This study investigated the function of perivascular adipose tissue (PVAT) on vascular contractility within resistant arteries in high-fat diet induced obese rats after long-term aerobic exercise. Male Sprague-Dawley rats were subjected to normal diet control group (N-CTRL), normal diet exercise group (N-EX), high-fat diet control group (H-CTRL), and high-fat diet exercise group (H-EX) (n = 8 in each group). After intervention, adipose tissues morphology was observed.

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In recent years, photoluminescent (PL) carbon dots (CDs) have attracted enormous attention because of their many fascinating properties. However, the traditional synthesis routes of PL CDs usually suffer from relatively low quantum yields (QYs) and require complicated operation processes as well as lots of externally supplied energy. Herein, we report a room temperature, green, ultrafast and energy-efficient route for large scale synthesis of highly PL N, S-codoped CDs without any external energy supply.

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Aims: This study investigated the effects of exercise and diet intervention on appetite-regulating hormones and subjective appetite changes in obese children and examined expressions of specific key microRNAs (miRNA, miR).

Methods: 16 obese children were included in a training program consisting of exercise and diet intervention for 6 weeks. Before and after the intervention, fasting blood was collected to determine appetite-regulating hormones (leptin, ghrelin, and orexin) and miRNA (miR-103a-3p and miR-200a-3p) levels; eating behavior of the children was reported using the Children Eating Behavior Questionnaire (CEBQ).

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Article Synopsis
  • The study focused on the effects of a 6-week combined exercise and dietary program on obese adolescents, examining factors like arterial stiffness, central blood pressure, and heart function.
  • Results showed significant improvements in body weight, heart rate, and blood pressure, as well as reductions in arterial stiffness measurements.
  • Participants experienced enhanced cardiac autonomic function, suggesting better heart health after the intervention, alongside positive changes in metabolic parameters.
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Most commercial permanent hair dyeing technologies are based on the oxidative process of -phenylenediamine and its derivative materials. However, concerns about their toxicological issues have been raised throughout the years. Herein, we report an innovative surface coloration strategy for fabricating melanin-mimetic multicolor and low-toxicity hair dyes through sodium periodate-induced rapid deposition of eumelanin-like polydopamine (PDA) and pheomelanin-like PDA/cysteine co-deposited coatings on the hair surface.

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Irisin is a circulating myokine induced by exercise, which is a cleaved version of fibronectin type III domain containing protein 5 (FNDC5). It can promote the browning of white fat tissue, increase energy consumption, and decrease weight. Irisin plays an important role in the regulation of various diseases, such as diabetes and coronary heart disease.

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Objective: To explore the genetic basis of cerebral palsy (CP).

Methods: A pair of twins with cerebral palsy and different phenotypes were subjected to whole genome sequencing, and other 8 children with CP were subjected to whole exome sequencing. Genetic variations were screened by a self-designed filtration process in order to explore the CP-related biological pathways and genes.

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In recent years, polydopamine (PDA) nanoparticles have attracted considerable attention in different research fields because of their many fascinating physicochemical properties. However, as an analogue of naturally occurring melanin, PDA nanoparticles (PDANPs) typically exhibit weak fluorescence properties. Herein, we report a facile one-pot method for synthesizing bright blue luminescent PDANPs through the redox modulation of PDA surface chemistry.

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Cerebral palsy (CP) is a non-progressive neurological disease, of which susceptibility is linked to genetic and environmental risk factors. More and more studies have shown that CP might be caused by multiple genetic factors, similar to other neurodevelopmental disorders. Due to the high genetic heterogeneity of CP, we focused on investigating related molecular pathways.

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Article Synopsis
  • - The study investigates the relationship between circulating endothelial progenitor cells (EPCs) and obesity, finding that exercise helps to restore EPC levels in obese individuals and suggesting that irisin might be a key factor in this process.
  • - After an 8-week exercise and dietary program with 17 obese adults, researchers noted significant increases in circulating irisin and EPC levels, along with enhanced EPC functions like migration and adhesion.
  • - The findings highlight a positive correlation between increased irisin and EPC levels, suggesting that irisin may play an important role in improving vascular health in obese individuals following exercise interventions.
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