Publications by authors named "Honggang Wang"

Macroautophagy/autophagy, an evolutionarily conserved cellular degradation pathway, involves phagophores that sequester cytoplasmic constituents and mature into autophagosomes for subsequent lysosomal delivery. The gene family, comprising the and subfamilies in mammals, encodes ubiquitin-like proteins that are conjugated to phagophore membranes during autophagosome biogenesis. A central question in the field is how Atg8-family proteins are precisely involved in autophagosome formation, which remains controversial and challenging, at least in part due to the short lifespan of phagophores.

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Ferroptosis is a new kind of cell death discovered in recent years, usually accompanied by a large number of lipid peroxidation and iron accumulation in the process of cell death. Ferroptosis has been proven to play an important role in various diseases, including ischemic reperfusion injury, cancer, and neurodegeneration. Therefore, the regulation of ferroptosis will have a vital impact on the occurrence and development of diseases.

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Article Synopsis
  • Macroautophagy involves creating structures called autophagosomes for cellular cleanup, and disrupting their closure has unknown effects.
  • Researchers created mice with a specific mutation that impairs autophagosome closure, resulting in various issues like protein buildup and growth problems, though some survive into adulthood.
  • The study found that this mutation causes the buildup of a protein (TBK1) on forming autophagosomes, leading to increased phosphorylation and aggregation of other proteins, suggesting a new role for these structures in managing cellular waste.
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Background: Neuroblastoma is a common pediatric solid tumor with poor outcomes in high-risk patients. The identification of new therapeutic biomarkers is critical for the treatment of disease.

Methods: An analysis of large publicly available datasets of tumor gene expression was performed.

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Rye ( L.) genes, which contribute to the tertiary gene pool of wheat, include multiple disease resistance genes useful for the genetic improvement of wheat. Introgression lines are the most valuable materials for wheat breeding because of their small alien segments and limited or lack of linkage drag.

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German chamomile (Matricaria chamomilla L.) is a traditional medicinal aromatic plant, and the sesquiterpenoids in its flowers have important medicinal value. The (E)-β-farnesene (EβF) is one of the active sesquiterpenoid components and is also a major component of aphid alarm pheromones.

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The NACHT, LRR, and PYD domains-containing protein 3 (NLRP3) inflammasome consists of pro-caspase-1, NLRP3 and apoptosis-related speckle-like protein (ASC). It can detect multiple microorganisms, endogenous danger signals and environmental stimulus including adenosine triphosphate (ATP), urate, cholesterol crystals, and so on, thereby forming activated NLRP3 inflammasome. During the course of the activation of NLRP3 inflammasome, pro-caspase-1 is transformed into activated caspase-1 that results in the maturation and secretion of interleukin-1beta (IL-1β) and IL-18.

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  • * Researchers created a G406R knockin mouse model that exhibits TS features, including hypoglycemia, but surprisingly does not show increased beta cell activity or hyperinsulinism.
  • * The study unveils alternative mechanisms for hypoglycemia, such as impaired hormone responses and disrupted hypothalamic regulation of glucose levels, enhancing our understanding of how mutant channels impact TS.
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Attitude information is as important as position information in describing and localizing objects. Based on this, this paper proposes a method for object attitude sensing utilizing ultra-high frequency passive RFID technology. This method adopts a double tag array strategy, which effectively enhances the spatial freedom and eliminates phase ambiguity by leveraging the phase difference information between the two tags.

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The key to improving function of an impaired limb after unilateral brain injury is promotion of corticospinal tract (CST) sprouting across the midline into the denervated hemicord. Previous studies have unveiled specific genes that regulate CST sprouting. CST sprouting may also be regulated by RNA modification.

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Background: This study examines the complex relationships among the neuroendocrine axis, gut microbiome, inflammatory responses, and gastrointestinal symptoms in patients with irritable bowel syndrome (IBS). The findings provide new insights into the pathophysiology of IBS and suggest potential therapeutic targets for improving patient outcomes.

Aim: To investigate the interactions between the neuroendocrine axis, gut microbiome, inflammation, and gastrointestinal symptoms in patients with IBS.

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Utilizing reliable and accurate positioning and navigation systems is crucial for saving the lives of rescue personnel and accelerating rescue operations. However, Global Navigation Satellite Systems (GNSSs), such as GPS, may not provide stable signals in dense forests. Therefore, integrating multiple sensors like GPS and Inertial Measurement Units (IMUs) becomes essential to enhance the availability and accuracy of positioning systems.

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Aberrant mitochondrial fission/fusion dynamics are frequently associated with pathologies, including cancer. We show that alternative splice variants of the fission protein Drp1 (DNM1L) contribute to the complexity of mitochondrial fission/fusion regulation in tumor cells. High tumor expression of the Drp1 alternative splice variant lacking exon 16 relative to other transcripts is associated with poor outcome in ovarian cancer patients.

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  • - MicroRNAs (miRNAs) are short non-coding RNAs that control gene expression by degrading or inhibiting specific messenger RNAs (mRNAs), affecting about one-third of protein-coding genes and influencing processes like cell growth and apoptosis.
  • - Hydrogen sulfide (HS), once thought of as a toxic gas, has emerged as an important gas signaling molecule that plays crucial biological roles, particularly in relation to ischemia-reperfusion (I/R) injury.
  • - This review explores the relationship between HS and miRNA regulation in the context of I/R injury, detailing the mechanisms involved but noting that the exact processes are still not completely understood.
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  • Necroptosis is a specific type of programmed cell death mediated by proteins RIPK1, RIPK3, and MLKL, forming a complex called the necrosome, which is relevant in various disease processes.
  • Recent studies suggest that hydrogen sulfide (HS), once thought solely to be a toxic gas, is now recognized for its significant roles as a gas signaling molecule, similar to carbon monoxide and nitric oxide.
  • The text discusses the emerging research on how HS influences necroptosis and its involvement in different pathological conditions, emphasizing the need to understand these mechanisms for disease prevention and treatment.
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  • Nonalcoholic fatty liver disease (NAFLD) has been rebranded as metabolic dysfunction-associated fatty liver disease (MAFLD), and both MAFLD and osteoporosis are common metabolic conditions that affect many people.
  • Research shows that NAFLD increases the risk of low bone density and osteoporosis, especially due to its connection with obesity, which was earlier thought to be protective against bone loss but is now linked to higher fracture risk.
  • The study reviews literature highlighting the connections among obesity, MAFLD, and osteoporosis, suggesting mechanisms like inflammation, insulin resistance, and gut microbiota imbalance, proposing that understanding these links can lead to new treatment strategies for affected individuals.
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  • * A study conducted on 529 IBD patients during the COVID-19 pandemic found that those with ulcerative colitis (UC) were more worried about going out compared to those with Crohn's disease (CD), although both groups shared concerns about restroom access.
  • * A high percentage of patients with active IBD (85.4%) expressed anxiety about public washroom availability, underscoring the psychological challenges they face when engaging in daily activities.
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Ferroptosis is a programmed cell death that relies on iron and lipid peroxidation. It differs from other forms of programmed cell death such as necrosis, apoptosis and autophagy. More and more evidence indicates that ferroptosis participates in many types of diseases, such as neurodegenerative diseases, ischemia-reperfusion injury, cardiovascular diseases and so on.

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Background: Emerging data identifies aquaporin 5 (AQP5) as a vital player in many kinds of cancers. Over expression of AQP5 was associated with increased metastasis and poor prognosis, suggesting that AQP5 may facilitate cancer cell proliferation and migration. Our previous studies also showed that AQP3 and AQP5 were highly expressed in triple-negative breast cancer (TNBC) and the expression of AQP3 and AQP5 in TNBC tissue was positive correlated with advanced clinical stage.

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  • * In this study, 47 bZIP genes from a specific plant genome were identified and categorized into 11 subfamilies, with analyses performed on chromosome distribution, gene replication, and expression patterns.
  • * The research highlighted ten candidate genes linked to plant development and identified four genes responsive to drought and salt stress, indicating potential roles in adapting to environmental challenges.
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NLRP3 inflammasome is a key component of the innate immune system, mediating the activation of caspase-1, and the maturity and secretion of the pro-inflammatory cytokine interleukin (IL)-1beta (IL-1β) and IL-18 to cope with microbial infections and cell injury. The NLRP3 inflammasome is activated by various endogenous danger signals, microorganisms and environmental stimuli, including urate, extracellular adenosine triphosphate (ATP) and cholesterol crystals. Increasing evidence indicates that the abnormal activation of NLRP3 is involved in multiple diseases including renal diseases.

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The objective of this investigation was to analyse the correlation between the neutrophil-to-lymphocyte ratio (NLR) status in the immune microenvironment (IME) and the prognostic outcomes of patients who have undergone radical surgery for colorectal cancer (CRC). In light of the continued prevalence of CRC in China, this study utilised Kaplan-Meier and Cox regression analyses to assess the prognostic relevance of NLR status in IME among patients with CRC. Furthermore, cellular experiments, such as cell scratching, were conducted to elucidate the underlying mechanisms of NLR's impact on CRC.

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