Tetramethylpyrazine Nitrone in Amyotrophic Lateral Sclerosis: A Randomized Clinical Trial.

Importance: Tetramethylpyrazine nitrone has exhibited promising results in improving motor dysfunction in neurodegenerative diseases, including amyotrophic lateral sclerosis (ALS).

Objective: To evaluate the safety and efficacy of orally administered tetramethylpyrazine nitrone in patients with ALS.

Design, Setting, And Participants: This phase 2, multicenter, double-masked, placebo-controlled, randomized clinical trial was conducted from December 24, 2020, through July 14, 2023, in 11 centers in China, with a 180-day follow-up.

Theoretical study of mode competition including backward wave and experiment on the 28 GHz second harmonic gyrotron.

The gyrotron operates in the harmonic state, which can significantly reduce the required operating magnetic field but complicates the mode competition problem. In some situations, it is also possible for the backward wave of the fundamental wave mode to be excited to suppress the desired harmonic operating mode. Therefore, a detailed analysis of mode competition is necessary for gyrotrons operating in the harmonic state.

Biallelic variants in SREBF2 cause autosomal recessive spastic paraplegia.

Hereditary spastic paraplegias (HSPs) refer to a genetically and clinically heterogeneous group of neurodegenerative disorders characterized by the degeneration of motor neurons. To date, a significant number of patients still have not received a definite genetic diagnosis. Therefore, identifying unreported causative genes continues to be of great importance.

Single-Nucleus RNA Sequencing Reveals the Spatiotemporal Dynamics of Disease-Associated Microglia in Amyotrophic Lateral Sclerosis.

Disease-associated microglia (DAM) are observed in neurodegenerative diseases, demyelinating disorders, and aging. However, the spatiotemporal dynamics and evolutionary trajectory of DAM during the progression of amyotrophic lateral sclerosis (ALS) remain unclear. Using a mouse model of ALS that expresses a human gene mutation, we found that the microglia subtype DAM begins to appear following motor neuron degeneration, primarily in the brain stem and spinal cord.

Deoxycholic acid aggravates necrotizing enterocolitis through downregulation of mesenchymal-epithelial transition factor expression.

Bile acids are closely associated with necrotizing enterocolitis (NEC), and their accumulation has cytotoxic effects on cells. However, the specific bile acid subtype involved in NEC and its underlying mechanisms remains poorly understood, limiting the therapeutic potential of bile acids as treatment targets. In the present study, deoxycholic acid (DCA) accumulation in the intestinal lumen exacerbated NEC-induced intestinal damage.

Clinical characterization and founder effect analysis in Chinese amyotrophic lateral sclerosis patients with common variants.

Objective: In the Asian population, variants are the most common cause of amyotrophic lateral sclerosis (ALS). To date, more than 200 variants have been reported in . This study aimed to summarize the genotype-phenotype correlation and determine whether the patients carrying common variants derive from a common ancestor.

Major Bitter-Tasting Compounds from the Dichloromethane Fraction of Bitter Gourd (Fruit of L.) Extract and Their Precursors.

The unripe fruit of the plant L., commonly known as bitter gourd or bitter melon, is a popular vegetable and medical herb in many parts of the world and is characterized by its strong bitter taste. In our endeavor to decode its bitter taste, the dichloromethane fraction of 75% methanol extract of bitter gourd was found to be intensely bitter.

Blood diagnostic and prognostic biomarkers in amyotrophic lateral sclerosis.

Amyotrophic lateral sclerosis is a devastating neurodegenerative disease for which the current treatment approaches remain severely limited. The principal pathological alterations of the disease include the selective degeneration of motor neurons in the brain, brainstem, and spinal cord, as well as abnormal protein deposition in the cytoplasm of neurons and glial cells. The biological markers under extensive scrutiny are predominantly located in the cerebrospinal fluid, blood, and even urine.

Development and Application of a qPCR-Based Method Coupled with Spore Trapping to Monitor Airborne Pathogens of Wheat Causing Stripe Rust, Powdery Mildew, and Fusarium Head Blight.

Common wheat ( L.) production in China is challenged by stripe (yellow) rust, powdery mildew, and Fusarium head blight. Airborne inoculum of these pathogens is the causative driver of disease epidemics.

Wheat Stripe Rust Inoculum from the Southwest Dispersed to the East Huang-Huai-Hai Region Through Southern Anhui in China.

Stripe rust, caused by f. sp. , is a continuous threat to global wheat production.

A Two-Layer Graphene Nonwoven Fabric for Effective Electromagnetic Interference Shielding.

Rapid advancements and proliferation of electronic devices in the past decades have significantly intensified electromagnetic interference (EMI) issues, driving the demand for more effective shielding materials. Herein, we introduce a novel two-layer graphene nonwoven fabric (2-gNWF) that shows excellent EMI shielding properties. The 2-gNWF fabric comprises a porous fibrous upper layer and a dense conductive film-like lower layer, specifically designed to enhance EMI shielding through the combined mechanisms of reflection, multiple internal reflections, and absorption of electromagnetic waves.

Evaluation of hemostatic, anti-inflammatory, wound healing, skin irritation and allergy, and antimicrobial properties of active fraction from the ethanol extract of Chromolaena odorata (L.) R.M. King & H. Rob.

Ethnopharmacological Relevance: Chromolaenaodorata (L.) R.M.

20 potentially new compounds and 11 new bioactive constituents found in Smilacis Glabrae Rhizoma utilizing HPLC-DAD-ESI-IT-TOF-MS.

Introduction: Smilacis Glabrae Rhizoma (SGR) is rich in chemical constituents with a variety of pharmacological activities. However, in-depth research has yet to be conducted on the chemical and pharmacodynamic constituents of SGR.

Materials And Methods: In this study, the chemical constituents of SGR were analyzed using liquid chromatography-mass spectrometry, and the pharmacodynamic compounds responsible for the medicinal effects of SGR were elucidated through a literature review.

Both gain- and loss-of-function variants of KCNA1 are associated with paroxysmal kinesigenic dyskinesia.

KCNA1 is the coding gene for Kv1.1 voltage-gated potassium-channel α subunit. Three variants of KCNA1 have been reported to manifest as paroxysmal kinesigenic dyskinesia (PKD), but the correlation between them remains unclear due to the phenotypic complexity of KCNA1 variants as well as the rarity of PKD cases.

Low-Density and High-Performance Fiber-Reinforced PP/POE Composite Foam via Irradiation Crosslinking.

This study addresses the challenge of achieving foam with a high expansion ratio and poor mechanical properties, caused by the low melt viscosity of semi-crystalline polypropylene (PP). We systematically employ a modification approach involving blending PP with polyolefin elastomers (POE), irradiation crosslinking, and fiber reinforcement to prepare fiber-reinforced crosslinked PP/POE composite foam. Through optimization and characterization of material composition and processing conditions, the obtained fiber-reinforced crosslinked PP/POE composite foam exhibits both low density and high performance.

Continuous CF/PA6 Composite Aircraft Window Frame Manufactured via a Novel Winding Compression Process.

Using fiber-reinforced polymer composite to replace metal in window frames has become a trend in aircraft manufacturing to achieve structural weight reduction. This study proposes an innovative winding compression molding process for continuous production of aircraft window frames using continuous carbon fiber-reinforced polyamide 6 thermoplastic composite filaments (CF/PA6). Through process parameter optimization, the production cycle of CF/PA6 composite window frames was controlled within 5 min, with an ultra-low porosity of 0.

Innovative CF/PVC Foam Applicated for Automotive Synthetic Leather with High-Performance and Reduced VOC Emissions.

Polyvinyl chloride (PVC) foam, valued for its mechanical and thermal properties along with cost-effectiveness, is extensively utilized across diverse industries. However, its high volatile organic compound (VOC) emissions hinder its adoption in eco-friendly synthetic leather. This study proposes a solution by optimizing the formulation design and foaming processes and achieving mechanical property enhancement via carbon-fiber-reinforced PVC composite foam (CF/PVC).

Balanced Thermal Insulation, Flame-Retardant and Mechanical Properties of PU Foam Constructed via Cost-Effective EG/APP/SA Ternary Synergistic Modification.

To address the challenge of balancing the mechanical, thermal insulation, and flame-retardant properties of building insulation materials, this study presented a facile approach to modify the rigid polyurethane foam composites (RPUFs) via commercial expandable graphite (EG), ammonium polyphosphate (APP), and silica aerogel (SA). The resulting EG/APP/SA/RPUFs exhibited low thermal conductivity close to neat RPUF. However, the compressive strength of the 6EG/2APP/SA/RPUF increased by 49% along with achieving a V-0 flame retardant rating.

Long-Range Hot-Carrier Transport in Topologically Connected HgTe Quantum Dots.

The utilization of hot carriers as a means to surpass the Shockley-Queasier limit represents a promising strategy for advancing highly efficient photovoltaic devices. Quantum dots, owing to their discrete energy states and limited multi-phonon cooling process, are regarded as one of the most promising materials. However, in practical implementations, the presence of numerous defects and discontinuities in colloidal quantum dot (CQD) films significantly curtails the transport distance of hot carriers.

Melatonin alleviates necrotizing enterocolitis by reducing bile acid levels through the SIRT1/FXR signalling axis.

Bile acids (BAs) have increasingly been implicated in the onset and progression of necrotizing enterocolitis (NEC); multiple findings have demonstrated their ability to induce damage to the intestinal epithelium, thereby exacerbating disease severity. Although we previously showed that melatonin was able to treat NEC by correcting the Treg/Th17 imbalance, the modulatory effect of melatonin on BAs remains unclear. In this study, we conducted transcriptome analysis on intestinal tissues from patients with NEC and validated these findings.