Development and Validation of a Non-Invasive Prediction Model for Glioma-Associated Epilepsy: A Comparative Analysis of Nomogram and Decision Tree.

Objective: Glioma-associated epilepsy (GAE) is a common neurological symptom in glioma patients, which can worsen the condition and increase the risk of death on the basis of primary injury. Given this, accurate prediction of GAE is crucial, and this study aims to develop and validate a GAE warning recognition prediction model.

Methods: We retrospectively collected MRI scan imaging data and urine samples from 566 glioma patients at the Xiangyang Central Hospital, Affiliated Hospital of Hubei University of Arts and Science from August 2016 to December 2023.

Exploring Modeling Techniques for Soft Arms: A Survey on Numerical, Analytical, and Data-Driven Approaches.

Soft arms, characterized by their compliance and adaptability, have gained significant attention in applications ranging from industrial automation to biomedical fields. Modeling these systems presents unique challenges due to their high degrees of freedom, nonlinear behavior, and complex material properties. This review provides a comprehensive overview of three primary modeling approaches: numerical methods, analytical techniques, and data-driven models.

Wetting Characteristics and Microscopic Synergistic Mechanism of Composite Surfactants on Coal Samples with Different Degrees of Metamorphosis.

This study investigates the effects of composite surfactants on the wettability of different coal types using a combination of macroscopic experiments, mesoscopic experiments, and microscopic molecular dynamics simulations, with coal samples of varying degrees of metamorphism as research subjects. First, contact angle and surface tension experiments were performed at the macroscopic level to determine the optimal concentration and ratio of the composite surfactants. The results showed that the composite solution formed by mixing SLES and AEO-9 in a 3:2 ratio significantly reduced both the surface tension of the solution and the contact angle of the coal samples at a mass concentration of 0.

A Linear Rehabilitative Motion Planning Method with a Multi-Posture Lower-Limb Rehabilitation Robot.

In rehabilitation, physicians plan lower-limb exercises via linear guidance. Ensuring efficacy and safety, they design patient-specific paths, carefully plotting smooth trajectories to minimize jerks. Replicating their precision in robotics is a major challenge.

Higher Serum Galectin‑3 Levels Were Associated with More Severe Motor Performance in Parkinson's Disease.

Background: Parkinson's disease (PD) is a movement disorder that lacks proven biomarkers. Case-control genome-wide association studies revealed the potential effect of galectin‑3 (GAL3) on motor progression in PD patients. Based on this finding, our study aimed to explore the correlation between serum GAL3 levels and motor performance in PD patients.

Association Between Serum Interleukin-32 Level and Disease Status in Cases with Neuromyelitis Optica Spectrum Disorders.

Background: Various cytokines are involved in the pathogenesis of neuromyelitis optica spectrum disorders (NMOSD), but whether serum interleukin-32 (IL-32) level is related to disease activity in cases with NMOSD remains poorly understood. Thus, we investigated the underlying role of IL-32 in NMOSD cases.

Methods: Our observation recruited 32 cases with acute NMOSD, 36 NMOSD cases in remission, and 60 healthy individuals in this study.

Extraction methods, chemical compositions, molecular structure, health functions, and potential applications of tea polysaccharides as a promising biomaterial: a review.

Tea polysaccharides (TPS) have attracted much attention due to their multiple biological activities, excellent biocompatibility and good biodegradability, creating a wide range of potential applications in the food and pharmaceutical industries. However, the high molecular weight and complexity of TPS components have restricted its purification and bioactivity, limiting its potential applications. In this review, the effects of various extraction methods, tea processing, and degree of fermentation on the composition and structure of TPS were thoroughly investigated to overcome this dilemma.

Metabolism mechanisms of biogenic methane production by synergistic biodegradation of lignite and guar gum.

Coalbed methane (CBM) presents a promising energy source for addressing global energy shortages. Nonetheless, challenges such as low gas production from individual wells and difficulties in breaking gels at low temperatures during extraction hinder its efficient utilization. Addressing this, we explored native microorganisms within coal seams to degrade guar gum, thereby enhancing CBM production.

A Multistage Hemiplegic Lower-Limb Rehabilitation Robot: Design and Gait Trajectory Planning.

Most lower limb rehabilitation robots are limited to specific training postures to adapt to stroke patients in multiple stages of recovery. In addition, there is a lack of attention to the switching functions of the training side, including left, right, and bilateral, which enables patients with hemiplegia to rehabilitate with a single device. This article presents an exoskeleton robot named the multistage hemiplegic lower-limb rehabilitation robot, which has been designed to do rehabilitation in multiple training postures and training sides.

The relationship between body dissatisfaction, lifestyle, and nutritional status among university students in Southern China.

Background: In recent years, obesity in early adulthood has become an urgent global public health concern. Body dissatisfaction may have adverse effects on lifestyle habits, leading to obesity. However, research on nutritional status and body dissatisfaction among Chinese young adults is still insufficient.

Methyl radical chemistry in non-oxidative methane activation over metal single sites.

Molybdenum supported on zeolites has been extensively studied as a catalyst for methane dehydroaromatization. Despite significant progress, the actual intermediates and particularly the first C-C bond formation have not yet been elucidated. Herein we report evolution of methyl radicals during non-oxidative methane activation over molybdenum single sites, which leads selectively to value-added chemicals.

Microbial community succession and volatile compounds changes during spontaneous fermentation of Cabernet Sauvignon ( L.) under rain-shelter cultivation.

Microbiota succession in spontaneous fermentation of Cabernet Sauvignon cultivated under the rain-shelter was characterized, with open-field cultivation as the control. For both cultivation modes, , , and were the principal fungi, and , , and were the prevailing bacteria. Rain-shelter reduced the abundance of , , , , and .

Glucose metabolic reprogramming and its therapeutic potential in obesity-associated endometrial cancer.

Endometrial cancer (EC) is a common gynecological cancer that endangers women health. Although substantial progresses of EC management have been achieved in recent years, the incidence of EC still remains high. Obesity has been a common phenomenon worldwide that increases the risk of EC.

Leveraging 16S rRNA data to uncover vaginal microbial signatures in women with cervical cancer.

Microbiota-relevant signatures have been investigated for human papillomavirus-related cervical cancer (CC), but lack consistency because of study- and methodology-derived heterogeneities. Here, four publicly available 16S rRNA datasets including 171 vaginal samples (51 CC versus 120 healthy controls) were analyzed to characterize reproducible CC-associated microbial signatures. We employed a recently published clustering approach called VAginaL community state typE Nearest CentroId clAssifier to assign the metadata to 13 community state types (CSTs) in our study.

Tolerance for Housing Unaffordability among Highly Skilled Young Migrants: Evidence from the Zhejiang Province of China.

Many studies have concluded that, since housing pressure affects the mobility of highly skilled young migrants (HSYMs) in Chinese cities and regions, it is necessary to apply corresponding housing policies to adjust housing unaffordability for HYSM. This study uses data from a survey conducted in China's Zhejiang Province, where specific policies have been implemented to attract talent. We found that housing crowds out HSYM from a city, but that the HSYM who have a master's degree or above, or who work in government organizations or state-owned enterprises, are more tolerant of housing unaffordability.

Patterns of lymph node metastases and their implications in individualized radiotherapeutic clinical target volume delineation of regional lymph nodes in patients with endometrial cancer.

To study the patterns of lymph node metastasis (LNM) of endometrial cancer (EC) and to clarify the individualized clinical target volume delineations of regional lymph nodes (CTVn). Data from a total of 556 patients with EC who had undergone total hysterectomy associated with bilateral salpingo-oophorectomy (TH/BSO) and systematic lymphadenectomy were retrospectively examined. The clinicopathological factors related to LNM were analyzed using logistic regression analysis.

ENO2 Promotes Colorectal Cancer Metastasis by Interacting with the LncRNA CYTOR and Activating YAP1-Induced EMT.

The glycolytic enzyme enolase 2 (ENO2) is dysregulated in many types of cancer. However, the roles and detailed molecular mechanism of ENO2 in colorectal cancer (CRC) metastasis remain unclear. Here, we performed a comprehensive analysis of ENO2 expression in 184 local CRC samples and samples from the TCGA and GEO databases and found that ENO2 upregulation in CRC samples was negatively associated with prognosis.

Long Noncoding RNA MIR4435-2HG Suppresses Colorectal Cancer Initiation and Progression By Reprogramming Neutrophils.

MIR4435-2HG, also known as LINC00978, has previously been described as an oncogenic long noncoding RNA (lncRNA). However, we show here that Mir4435-2hg depletion promoted colorectal tumorigenesis and progression in in vivo models of colitis-associated colorectal cancer, spontaneous intestinal adenomatous polyposis, and subcutaneous tumors. Alteration of MIR4435-2HG in colorectal cancer cells did not change the potential for cell proliferation, migration, or invasion in vitro.

Evaluation of rain-shelter cultivation mode effects on microbial diversity during Cabernet Sauvignon (Vitis vinifera L.) maturation in Jingyang, Shaanxi, China.

Rainfall particularly under continental climates with monsoonal tendency impacts the vineyard microbial niches during grapevine growth. With microbial community shifts, vine traits (grape flavor and yield) cultivated/protected under rain-shelter may ultimately be altered. Such cultivation may influence microflora dynamics via meteorological parameter variations, however this is unclear yet.

LncRNA CASC15, MiR-23b Cluster and SMAD3 form a Novel Positive Feedback Loop to promote Epithelial-Mesenchymal Transition and Metastasis in Ovarian Cancer.

Cancer Susceptibility Candidate 15 (CASC15), which is a newly identified long noncoding RNA crucial for epigenetic regulation in human tumors, was found to be associated with poor prognosis of the patients with ovarian cancer by utilizing The Cancer Genome Atlas and Gene Expression Omnibus database. Therefore, the purpose of this paper was to explore the functional role and latent molecular mechanism of CASC15 in the progression of ovarian cancer. and experiments validated CASC15 as an oncogenic lncRNA in ovarian cancer, which could enhance metastasis through TGF-β-induced epithelial-mesenchymal transition progress.

Reference Genes for Expression Analyses by qRT-PCR in (Lepidoptera: Gelechiidae).

Due to a lack of effective internal references, studies on functional genes in , a serious Lepidopteran pest attacking potatoes worldwide, have been greatly limited. To select suitable endogenous controls, ten housekeeping genes of actin (), α-tubulin (), glyceraldehyde-3-phosphate dehydrogenase (), elongation factor 1α (), and ribosomal RNA (, ), ribosomal protein genes , and and superoxide dismutase () were tested. Their expression levels were determined under three different experimental conditions (developmental stages, tissues/organs and temperatures) using qRT-PCR technology.

Tumor-suppressive circRHOBTB3 is excreted out of cells via exosome to sustain colorectal cancer cell fitness.

Background & Aims: To clarify the biological roles, circularization process and secretion pathway of circRHOBTB3 in colorectal cancer (CRC) progression.

Methods: We performed a comprehensive analysis of circRNA levels in serum exosomes from multiple types of cancer patients in public databases and verified the higher level of circRHOBTB3 in CRC sera versus healthy donors by RT-qPCR. Then, the function of circRHOBTB3 in CRC was investigated in vitro and in vivo.

Sexual debut among college students in China: effects of family context.

This study examines family context and sexual debut among young people in China. Using data from the 2018 Panel Study of Chinese University Students (PSCUS), it explores how the family is correlated with sexual debut among young people in China aged 18-24 years. The Kaplan-Meier method was adopted to detect a survival function for different family factors and related demographic variables.